Clayton Mansel
@claytonmansel.bsky.social
Future Physician-Scientist 👨🔬 | MSTP student studying genomic-informed risks assessments for dementia 🧬 🧠| Strong Towns Advocate 💪🌆 | Opinions my own.
This week I wrote about a provocative new study in Mol Psychiatry. The authors claim that most studies of post-mortem human brain tissue are invalid because the gene expression patterns change.
I read it closely and I am…. not convinced. See why ⬇️
open.substack.com/pub/overfitt...
I read it closely and I am…. not convinced. See why ⬇️
open.substack.com/pub/overfitt...
You can't correlate your way to causation
A new study of living brain gene expression could change neuroscience forever... if we believe it
open.substack.com
November 12, 2025 at 8:01 PM
This week I wrote about a provocative new study in Mol Psychiatry. The authors claim that most studies of post-mortem human brain tissue are invalid because the gene expression patterns change.
I read it closely and I am…. not convinced. See why ⬇️
open.substack.com/pub/overfitt...
I read it closely and I am…. not convinced. See why ⬇️
open.substack.com/pub/overfitt...
New guidelines out from @alzassociation.bsky.social
on the use of blood-based biomarkers.
Disappointing that they are for memory centers and not primary care where I think they have the most utility helping docs triage patients for referral
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
on the use of blood-based biomarkers.
Disappointing that they are for memory centers and not primary care where I think they have the most utility helping docs triage patients for referral
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Alzheimer's Association Clinical Practice Guideline on the use of blood‐based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings
OBJECTIVE AND SCOPE A panel of clinicians, subject-matter experts, and guideline methodologists convened by the Alzheimer's Association conducted a systematic review and formulated evidence-based re...
alz-journals.onlinelibrary.wiley.com
July 30, 2025 at 6:25 PM
New guidelines out from @alzassociation.bsky.social
on the use of blood-based biomarkers.
Disappointing that they are for memory centers and not primary care where I think they have the most utility helping docs triage patients for referral
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
on the use of blood-based biomarkers.
Disappointing that they are for memory centers and not primary care where I think they have the most utility helping docs triage patients for referral
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
🎉📄Excited to share a pre-print of my most recent PhD project: "Downward bias in the association between APOE and Alzheimer’s Disease using prevalent
and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)
and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)
May 27, 2025 at 6:08 PM
🎉📄Excited to share a pre-print of my most recent PhD project: "Downward bias in the association between APOE and Alzheimer’s Disease using prevalent
and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)
and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)
Jeremy in the trenches fighting for all of us! 👏
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
1/n
1/n
May 6, 2025 at 1:41 PM
Jeremy in the trenches fighting for all of us! 👏
Really excellent keynote speaker @bionexuskc.bsky.social by Dr. Tatonetti and well said - “observation is the starting point of biological discovery.”
April 10, 2025 at 8:40 PM
Really excellent keynote speaker @bionexuskc.bsky.social by Dr. Tatonetti and well said - “observation is the starting point of biological discovery.”
Reposted by Clayton Mansel
Congrats to @claytonmansel.bsky.social for his Nexus informatics poster receiving an honorable mention. @bionexuskc.bsky.social
April 10, 2025 at 6:13 PM
Congrats to @claytonmansel.bsky.social for his Nexus informatics poster receiving an honorable mention. @bionexuskc.bsky.social
Reposted by Clayton Mansel
Federal judge Angel Kelly has extended her hold on the NIH's overhead cut.
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
Federal Judge Extends TRO Against NIH Cap On Indirect Cost Payments
Federal Judge Angel Kelly has extended her temporary hold on NIH's plan to cap its payment of indirect research grant costs to 15%.
www.forbes.com
February 21, 2025 at 8:37 PM
Federal judge Angel Kelly has extended her hold on the NIH's overhead cut.
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
Reposted by Clayton Mansel
Just watched Secretary Kennedy's Speech to HHS Employees.
Key takeaways:
(1) NO ANNOUNCEMENT OF FIRINGS!
(2) Generally positive tone about science and scientists
(3) Set up some strawmen about lack of transparency but promising a new era of transparency
1/2
Key takeaways:
(1) NO ANNOUNCEMENT OF FIRINGS!
(2) Generally positive tone about science and scientists
(3) Set up some strawmen about lack of transparency but promising a new era of transparency
1/2
February 18, 2025 at 4:05 PM
Just watched Secretary Kennedy's Speech to HHS Employees.
Key takeaways:
(1) NO ANNOUNCEMENT OF FIRINGS!
(2) Generally positive tone about science and scientists
(3) Set up some strawmen about lack of transparency but promising a new era of transparency
1/2
Key takeaways:
(1) NO ANNOUNCEMENT OF FIRINGS!
(2) Generally positive tone about science and scientists
(3) Set up some strawmen about lack of transparency but promising a new era of transparency
1/2
Reposted by Clayton Mansel
If you wanted to cut waste, fraud, and abuse, you would empower the inspectors general.
If you wanted more waste, fraud, and abuse, you would fire them.
If you wanted more waste, fraud, and abuse, you would fire them.
February 17, 2025 at 2:17 PM
If you wanted to cut waste, fraud, and abuse, you would empower the inspectors general.
If you wanted more waste, fraud, and abuse, you would fire them.
If you wanted more waste, fraud, and abuse, you would fire them.
Reposted by Clayton Mansel
Defying defiance to the laws. Good for NIH!
BREAKING
On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders
On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.
On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders
On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
popular.info
February 12, 2025 at 7:39 PM
Defying defiance to the laws. Good for NIH!
This administration is determined to implement their priorities in the most bad-faith, disruptive way possible. If we are all about “merit” now why not just merge the Diversity F’s with the others? Ridiculous
The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?
February 7, 2025 at 8:24 PM
This administration is determined to implement their priorities in the most bad-faith, disruptive way possible. If we are all about “merit” now why not just merge the Diversity F’s with the others? Ridiculous
Reposted by Clayton Mansel
The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?
February 5, 2025 at 9:39 PM
The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?
Reposted by Clayton Mansel
Totally normal stuff here
January 25, 2025 at 7:52 PM
Totally normal stuff here
Reposted by Clayton Mansel
The Trump Administration Appears to Be Holding the NIH Hostage www.splinter.com/the-trump-ad...
The Trump Administration Appears to Be Holding the NIH Hostage
Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.
www.splinter.com
January 24, 2025 at 6:43 PM
The Trump Administration Appears to Be Holding the NIH Hostage www.splinter.com/the-trump-ad...
Reposted by Clayton Mansel
Hi, Vox reporter here: If you've had a study section, NIH travel, or other NIH-related meeting cancelled (or not), raise your hand! Reply or DM me, and repost for visibility if you're able.
#academicsky @drugmonkey.bsky.social
#academicsky @drugmonkey.bsky.social
January 23, 2025 at 6:03 PM
Hi, Vox reporter here: If you've had a study section, NIH travel, or other NIH-related meeting cancelled (or not), raise your hand! Reply or DM me, and repost for visibility if you're able.
#academicsky @drugmonkey.bsky.social
#academicsky @drugmonkey.bsky.social
This going to be so good and probably one of the most useful streetcar routes in the U.S. Can’t wait to ride!
We are absolutely swooning over these pics of #kcstreetcar 807 rolling through the Plaza on its 1st ever test run. 😍
January 23, 2025 at 11:56 PM
This going to be so good and probably one of the most useful streetcar routes in the U.S. Can’t wait to ride!
Reposted by Clayton Mansel
We are absolutely swooning over these pics of #kcstreetcar 807 rolling through the Plaza on its 1st ever test run. 😍
January 23, 2025 at 6:52 PM
We are absolutely swooning over these pics of #kcstreetcar 807 rolling through the Plaza on its 1st ever test run. 😍
Reposted by Clayton Mansel
One day, one toe in the water with Ambient AI Scribes. Interesting. I did not find it to be a game changer for documentation burden, but perhaps it is a paradigm shift back to being able to capture patient stories with detail and expressivity in a way busy clinicians may struggle to do. 9/x
January 18, 2025 at 10:17 PM
One day, one toe in the water with Ambient AI Scribes. Interesting. I did not find it to be a game changer for documentation burden, but perhaps it is a paradigm shift back to being able to capture patient stories with detail and expressivity in a way busy clinicians may struggle to do. 9/x
Excited to share a preprint of my first project from my PhD: Distinct Medical and Substance Use Histories Associate with Cognitive Decline in Alzheimer's Disease! 🧠
doi.org/10.1101/2024...
doi.org/10.1101/2024...
January 9, 2025 at 2:19 PM
Excited to share a preprint of my first project from my PhD: Distinct Medical and Substance Use Histories Associate with Cognitive Decline in Alzheimer's Disease! 🧠
doi.org/10.1101/2024...
doi.org/10.1101/2024...
I’m no fan of echo chambers but the critics of movers to Bluesky under-appreciate:
1) X has become the same thing but for the other side
2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style)
3) X’s algorithm rewards divisive, loud, controversial takes.
1) X has become the same thing but for the other side
2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style)
3) X’s algorithm rewards divisive, loud, controversial takes.
Elon Musk is directing harassment toward individual federal workers
Elon Musk is directing harassment toward individual federal workers
An old tactic returns.
buff.ly
November 23, 2024 at 1:40 AM
I’m no fan of echo chambers but the critics of movers to Bluesky under-appreciate:
1) X has become the same thing but for the other side
2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style)
3) X’s algorithm rewards divisive, loud, controversial takes.
1) X has become the same thing but for the other side
2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style)
3) X’s algorithm rewards divisive, loud, controversial takes.
Just yesterday I was scrolling at the *other* place and lamenting that institutions like my library haven’t made the switch… well, today is a new day! Welcome KC library @kclibrary.bsky.social ! 📚
Maybe bsky will become a thing after all
Maybe bsky will become a thing after all
November 21, 2024 at 3:23 AM
Just yesterday I was scrolling at the *other* place and lamenting that institutions like my library haven’t made the switch… well, today is a new day! Welcome KC library @kclibrary.bsky.social ! 📚
Maybe bsky will become a thing after all
Maybe bsky will become a thing after all
First day on Bluesky and @theverge.com has reactivated their account and Mark Cuban is posting about RSS feeds and I am so here for it
Congrats to @bluesky for all the new users
My 2 cents. Find every news source the has an RSS feed or equivalent and create accounts that that show their public deeds on here under @johndoetimesfeed
That way we all get access to news without having to wait for them to create accounts first.
My 2 cents. Find every news source the has an RSS feed or equivalent and create accounts that that show their public deeds on here under @johndoetimesfeed
That way we all get access to news without having to wait for them to create accounts first.
November 14, 2024 at 4:33 AM
First day on Bluesky and @theverge.com has reactivated their account and Mark Cuban is posting about RSS feeds and I am so here for it