Canadian Critical Care Trials Group (CCCTG)
@ccctg.bsky.social
Improving the care of critically ill patients through investigator-initiated research. Pan-Canadian partnership of over 350 scientists, patient partners, health care professionals, research coordinators and learners. Established 1989.
New in @NEJM: CCCTG and @anzics.bsky.social have published the SuDDICU study www.nejm.org/doi/full/10....
Selective Decontamination of the Digestive Tract during Ventilation in the ICU | NEJM
Whether selective decontamination of the digestive tract (SDD) reduces mortality among patients undergoing mechanical ventilation and whether it adversely affects microbial ecology in the intensive...
www.nejm.org
October 31, 2025 at 3:31 PM
New in @NEJM: CCCTG and @anzics.bsky.social have published the SuDDICU study www.nejm.org/doi/full/10....
Reposted by Canadian Critical Care Trials Group (CCCTG)
In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8
#LIVES2025 | @esicm.bsky.social
#LIVES2025 | @esicm.bsky.social
October 29, 2025 at 2:48 PM
In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8
#LIVES2025 | @esicm.bsky.social
#LIVES2025 | @esicm.bsky.social
Reposted by Canadian Critical Care Trials Group (CCCTG)
Consent documentation for clinical research guideline:
A core set of elements for participant consent documents to be used in clinical research across Canada.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500
A core set of elements for participant consent documents to be used in clinical research across Canada.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500
Core elements of consent documentation for clinical research in Canada: guidance for policy
Background: Consent forms have become too long and often do little to help people understand the risk elements of their participation in research, instead focusing on risk reduction for research insti...
www.cmaj.ca
September 15, 2025 at 7:31 PM
Consent documentation for clinical research guideline:
A core set of elements for participant consent documents to be used in clinical research across Canada.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500
A core set of elements for participant consent documents to be used in clinical research across Canada.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500
📣 The CCCTG and CIHR’s Ethics Office created a guideline for a simplified template for informed consent - published TODAY in @cmaj.ca
See the full guideline: www.cmaj.ca/lookup/doi/1...
See the full guideline: www.cmaj.ca/lookup/doi/1...
Core elements of consent documentation for clinical research in Canada: guidance for policy
Background: Consent forms have become too long and often do little to help people understand the risk elements of their participation in research, instead focusing on risk reduction for research insti...
www.cmaj.ca
September 15, 2025 at 3:12 PM
📣 The CCCTG and CIHR’s Ethics Office created a guideline for a simplified template for informed consent - published TODAY in @cmaj.ca
See the full guideline: www.cmaj.ca/lookup/doi/1...
See the full guideline: www.cmaj.ca/lookup/doi/1...
Tomorrow: In recognition of her pioneering research in critical care medicine, Dr Deborah Cook will be inducted into the Canadian Medical Hall of Fame. Congratulations to the 2025 Laureates!
Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social
Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social
June 18, 2025 at 3:31 PM
Tomorrow: In recognition of her pioneering research in critical care medicine, Dr Deborah Cook will be inducted into the Canadian Medical Hall of Fame. Congratulations to the 2025 Laureates!
Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social
Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social
Reposted by Canadian Critical Care Trials Group (CCCTG)
From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
June 14, 2025 at 4:51 AM
Reposted by Canadian Critical Care Trials Group (CCCTG)
From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
June 13, 2025 at 4:52 PM
From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
#CCR25 @criticalcarereviews.com
ja.ma/3TeogPR
Happening now! INdex Study Results at #CCR25. Catch the livestream: criticalcarereviews.com
June 13, 2025 at 2:28 PM
Happening now! INdex Study Results at #CCR25. Catch the livestream: criticalcarereviews.com
Reposted by Canadian Critical Care Trials Group (CCCTG)
Lauralyn McIntyre & Monica Taljaard summarise the FLUID trial presented yesterday at the Critical Care Reviews Meeting 2025 and simultaneously published in the @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
June 13, 2025 at 1:29 PM
Lauralyn McIntyre & Monica Taljaard summarise the FLUID trial presented yesterday at the Critical Care Reviews Meeting 2025 and simultaneously published in the @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25
Home
The most up-to-date critical care website in the world
criticalcarereviews.com
June 13, 2025 at 1:49 PM
INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25
Reposted by Canadian Critical Care Trials Group (CCCTG)
PROMIZING RCT@ccctg.bsky.social @criticalcarereviews.com #CCR25
In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67
@criticalcarereviews.com #CCR25
@criticalcarereviews.com #CCR25
June 13, 2025 at 1:03 PM
PROMIZING RCT@ccctg.bsky.social @criticalcarereviews.com #CCR25
Reposted by Canadian Critical Care Trials Group (CCCTG)
#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation
#CCR25
#CCR25
June 13, 2025 at 12:53 PM
#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation
#CCR25
#CCR25
Reposted by Canadian Critical Care Trials Group (CCCTG)
In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67
@criticalcarereviews.com #CCR25
@criticalcarereviews.com #CCR25
June 13, 2025 at 1:00 PM
In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67
@criticalcarereviews.com #CCR25
@criticalcarereviews.com #CCR25
Reposted by Canadian Critical Care Trials Group (CCCTG)
FLUID trial results are coming thick and fast!
📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!
📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!
June 12, 2025 at 3:06 PM
FLUID trial results are coming thick and fast!
📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!
📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!
The FLUID Trial Results were just presented at #CCR25 in Belfast. Congrats to the FLUID team! See the full trial results in @nejm.org: www.nejm.org/doi/full/10....
June 12, 2025 at 3:49 PM
The FLUID Trial Results were just presented at #CCR25 in Belfast. Congrats to the FLUID team! See the full trial results in @nejm.org: www.nejm.org/doi/full/10....
Reposted by Canadian Critical Care Trials Group (CCCTG)
Presented at #CCR25:
In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs
@criticalcarereviews.com
In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs
@criticalcarereviews.com
June 12, 2025 at 2:56 PM
Presented at #CCR25:
In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs
@criticalcarereviews.com
In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs
@criticalcarereviews.com
Reposted by Canadian Critical Care Trials Group (CCCTG)
Also the trial was fully data enabled allowing outcomes to be collected via routine data making the data collection super efficient 3/3
June 12, 2025 at 3:27 PM
Also the trial was fully data enabled allowing outcomes to be collected via routine data making the data collection super efficient 3/3
Reposted by Canadian Critical Care Trials Group (CCCTG)
Neat features including use of routine healthcare data to estimate the likely ICC and cluster autocorrelation coefficient which gave accurate estimates for the sample size calcs 2/3
June 12, 2025 at 3:27 PM
Neat features including use of routine healthcare data to estimate the likely ICC and cluster autocorrelation coefficient which gave accurate estimates for the sample size calcs 2/3
Reposted by Canadian Critical Care Trials Group (CCCTG)
Another super cluster crossover trial at #CCR25 - the FLUID trial (looking at Ringers lactate vs normal saline - at the system level). 1/3 See paper here … www.nejm.org/doi/full/10....
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline | NEJM
Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain. In an open-label, two-period, two-sequence, cross-sectional...
www.nejm.org
June 12, 2025 at 3:27 PM
Another super cluster crossover trial at #CCR25 - the FLUID trial (looking at Ringers lactate vs normal saline - at the system level). 1/3 See paper here … www.nejm.org/doi/full/10....
⏰ Coming up at 10:30 ET: Don't miss FLUID Trial Results, live from #CCR2025 in Belfast!
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com
Home
The most up-to-date critical care website in the world
criticalcarereviews.com
June 12, 2025 at 1:53 PM
⏰ Coming up at 10:30 ET: Don't miss FLUID Trial Results, live from #CCR2025 in Belfast!
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com
Reposted by Canadian Critical Care Trials Group (CCCTG)
Reposted by Canadian Critical Care Trials Group (CCCTG)
#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com
June 11, 2025 at 7:47 AM
#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com
Reposted by Canadian Critical Care Trials Group (CCCTG)
🚨 12 Major Critical Care Trials 🚨
🌟 Global experts
🗣️ Live discussion
📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡
🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪
🔗 https://criticalcarereviews.com/meetings/ccr25
🌟 Global experts
🗣️ Live discussion
📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡
🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪
🔗 https://criticalcarereviews.com/meetings/ccr25
June 7, 2025 at 11:26 AM
🚨 12 Major Critical Care Trials 🚨
🌟 Global experts
🗣️ Live discussion
📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡
🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪
🔗 https://criticalcarereviews.com/meetings/ccr25
🌟 Global experts
🗣️ Live discussion
📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡
🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪
🔗 https://criticalcarereviews.com/meetings/ccr25
Reposted by Canadian Critical Care Trials Group (CCCTG)
Thank you to all speakers at Spring Canadian Critical Care Translational Biology Group (CCCTBG) meeting in Magog, QC! 🇨🇦 Inspiring talks on microvascular monitoring in shock, immune responses in critical illness, preclinical models, endothelial protection in shock, and neuroprotection post-stroke 👏
June 1, 2025 at 1:59 AM
Thank you to all speakers at Spring Canadian Critical Care Translational Biology Group (CCCTBG) meeting in Magog, QC! 🇨🇦 Inspiring talks on microvascular monitoring in shock, immune responses in critical illness, preclinical models, endothelial protection in shock, and neuroprotection post-stroke 👏