CATH-Gene3D
@cathgene3d.bsky.social
CATH/Gene3D at University College London
Evolutionary relationships and classification of protein domains.
https://cathdb.info
https://ted.cathdb.info
Evolutionary relationships and classification of protein domains.
https://cathdb.info
https://ted.cathdb.info
Reposted by CATH-Gene3D
It was lovely to speak at the CATH 30 symposium, celebrating 30 years of the @cathgene3d.bsky.social protein structure classification database. I was presenting recent work on our new generative protein-family language model: preprint coming soon.
September 18, 2025 at 10:33 AM
It was lovely to speak at the CATH 30 symposium, celebrating 30 years of the @cathgene3d.bsky.social protein structure classification database. I was presenting recent work on our new generative protein-family language model: preprint coming soon.
Kickstarting our symposium “Protein Annotations in the age of AI” at UCL!
September 16, 2025 at 10:19 AM
Kickstarting our symposium “Protein Annotations in the age of AI” at UCL!
Congratulations @judewells.bsky.social!
Poster Prize Awarded at ISMB/ECCB 2025
Congratulations to Jude Wells for Design in voxel space, decode in smiles space: Plixer generates drug-like molecules for protein pockets
Congratulations to Jude Wells for Design in voxel space, decode in smiles space: Plixer generates drug-like molecules for protein pockets
PDB101: Poster Prize Awarded at ISMB/ECCB 2025
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
August 22, 2025 at 5:32 PM
Congratulations @judewells.bsky.social!
CATH turns 30 years old this year!
We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses.
www.eventbrite.co.uk/e/protein-an...
We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses.
www.eventbrite.co.uk/e/protein-an...
Protein Annotations in the age of AI
A not-for-profit symposium hosted at UCL - more details about speakers and venue below.
www.eventbrite.co.uk
August 22, 2025 at 10:45 AM
CATH turns 30 years old this year!
We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses.
www.eventbrite.co.uk/e/protein-an...
We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses.
www.eventbrite.co.uk/e/protein-an...
Another CATH outing at Greenwich Park after a lovely cruise along the Thames and a pub lunch!
August 20, 2025 at 6:18 PM
Another CATH outing at Greenwich Park after a lovely cruise along the Thames and a pub lunch!
Reposted by CATH-Gene3D
Our latest preprint is out on bioRxiv!
A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins!
We reveal biome-specific groups & over 11k novel domain combinations.
A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins!
We reveal biome-specific groups & over 11k novel domain combinations.
Metagenomic-scale analysis of the predicted protein structure universe
Protein structure prediction breakthroughs, notably AlphaFold2 and ESMfold, have led to an unprecedented influx of computationally derived structures. The AlphaFold Protein Structure Database now prov...
www.biorxiv.org
April 28, 2025 at 11:16 AM
Our latest preprint is out on bioRxiv!
A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins!
We reveal biome-specific groups & over 11k novel domain combinations.
A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins!
We reveal biome-specific groups & over 11k novel domain combinations.
Reposted by CATH-Gene3D
TED is a collaborative project between the structural bioinformatics groups of Professor David Jones & Professor Christine Orengo @cathgene3d.bsky.social at @ucl.ac.uk.
The TED integration is set to enhance the interpretability and usability of #AlphaFold predictions. Is this useful in your work?
The TED integration is set to enhance the interpretability and usability of #AlphaFold predictions. Is this useful in your work?
March 3, 2025 at 4:35 PM
TED is a collaborative project between the structural bioinformatics groups of Professor David Jones & Professor Christine Orengo @cathgene3d.bsky.social at @ucl.ac.uk.
The TED integration is set to enhance the interpretability and usability of #AlphaFold predictions. Is this useful in your work?
The TED integration is set to enhance the interpretability and usability of #AlphaFold predictions. Is this useful in your work?
Reposted by CATH-Gene3D
🚀 #AlphaFold Database update
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
March 3, 2025 at 4:33 PM
🚀 #AlphaFold Database update
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
CATHmas lunch 2024!
December 18, 2024 at 2:21 PM
CATHmas lunch 2024!
A new version of CATH, v4.4, is out! 🎉
Here’s a link to the manuscript in NAR.
Here’s a link to the manuscript in NAR.
CATH v4.4: major expansion of CATH by experimental and predicted structural data
Abstract. CATH (https://www.cathdb.info) is a structural classification database that assigns domains to the structures in the Protein Data Bank (PDB) and
academic.oup.com
November 20, 2024 at 12:52 PM
A new version of CATH, v4.4, is out! 🎉
Here’s a link to the manuscript in NAR.
Here’s a link to the manuscript in NAR.
Hi TED! 👋
Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all!
A joint effort with the Jones group at UCL Computer Science, here's a link to the article
www.science.org/doi/10.1126/...
1/6 🧵⤵️
Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all!
A joint effort with the Jones group at UCL Computer Science, here's a link to the article
www.science.org/doi/10.1126/...
1/6 🧵⤵️
Exploring structural diversity across the protein universe with The Encyclopedia of Domains
The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and ...
www.science.org
November 16, 2024 at 3:05 PM
Hi TED! 👋
Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all!
A joint effort with the Jones group at UCL Computer Science, here's a link to the article
www.science.org/doi/10.1126/...
1/6 🧵⤵️
Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all!
A joint effort with the Jones group at UCL Computer Science, here's a link to the article
www.science.org/doi/10.1126/...
1/6 🧵⤵️
Hello 🦋!
We are CATH! We classify protein domains in homologous superfamilies from the Protein Data Bank and AlphaFold Database!
Follow us for our latest research!
We are CATH! We classify protein domains in homologous superfamilies from the Protein Data Bank and AlphaFold Database!
Follow us for our latest research!
November 14, 2024 at 11:34 AM
Hello 🦋!
We are CATH! We classify protein domains in homologous superfamilies from the Protein Data Bank and AlphaFold Database!
Follow us for our latest research!
We are CATH! We classify protein domains in homologous superfamilies from the Protein Data Bank and AlphaFold Database!
Follow us for our latest research!