Carlos A. Sánchez León
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carlosasleon.bsky.social
Carlos A. Sánchez León
@carlosasleon.bsky.social
88 followers 160 following 16 posts
In vivo electrophysiology+2P calcium imaging. Postdoc at UCLA. Neuroscientist and gamer. Trying to understand how the brain works while enjoying the journey.
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carlosasleon.bsky.social
Carlos A. Sánchez León @carlosasleon.bsky.social · Apr 15
PREPRINT🚨Ever wonder how electrical⚡️ stimulation of the brain🧠modulates neuronal activity? Are you working with brain stim and variability makes you want to smash your pc and go to a mountain to grow tomatoes? Are you a family member or a friend who really appreciate me? 1/13
a man in a red shirt and black gloves is holding a box with the word success on it
ALT: a man in a red shirt and black gloves is holding a box with the word success on it
media.tenor.com
Reposted by Carlos A. Sánchez León
elaprenditivo.bsky.social
¿Sabes cuál es el origen del alfabeto que usamos hoy día? Un invento alucinante para el que tenemos que ir hasta el desierto del Sinaí para encontrarlo. Escúchalo completo en nuestro podcast: open.spotify.com/show/05xIjOr...
November 13, 2025 at 6:01 AM
Reposted by Carlos A. Sánchez León
elaprenditivo.bsky.social
El mejor momento para verlo o escucharlo. Feliz y terrorífica noche de #Halloween.

youtu.be/jxct9DU1LOw?...
La Santa Compaña: stranger things en la Galicia profunda
YouTube video by El Aprenditivo
youtu.be
October 31, 2025 at 10:39 PM
Reposted by Carlos A. Sánchez León
elaprenditivo.bsky.social
Volvemos con nuestro diario. Hoy os dejamos solamente un regalo visual. Os presentamos las versiones alternativas verdes de nuestra imagen. Verde oliva, claro. ¿A que son geniales?
October 9, 2025 at 11:30 AM
Reposted by Carlos A. Sánchez León
dmartimarti.bsky.social
Excited to share our latest work at Cabreiro lab!

Chemotherapy modulation by a cancer-associated microbiota metabolite

www.cell.com/cell-systems...

Here's what we discovered 🧵
Chemotherapy modulation by a cancer-associated microbiota metabolite
Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...
www.cell.com
September 10, 2025 at 7:28 PM
Reposted by Carlos A. Sánchez León
castuolizate.bsky.social
📜 Hace hoy 142 años, Badajoz amanecía tomada por militares republicanos. Un pronunciamiento olvidado intentó restaurar la República desde el corazón extremeño. Aquí va la historia de una ciudad sitiada por ideales. 🧵Hilo🧵
August 5, 2025 at 5:15 PM
Reposted by Carlos A. Sánchez León
pvallin.bsky.social
El mejor lugar del mundo en el mejor momento de su historia.

Saldrá en todas las portadas.
javierruiz.bsky.social Javier Ruiz @javierruiz.bsky.social · Jul 8
LA CRIMINALIDAD EN ESPAÑA CAE UN 2,8% EL ÚLTIMO AÑO Y ESTÁ EN MÍNIMOS HISTÓRICOS: 40,6 delitos por cada 1.000 habitantes, una de las más bajas del mundo.
- Los homicidios caen un 11%
- Los robos caen un 14%
- Los delitos sexuales suben por mayor conciencia en denuncia, pese a la alarma de VOX
July 8, 2025 at 4:16 PM
Reposted by Carlos A. Sánchez León
translationalbrainstim.com
🧵1/
🚨 New preprint out!
We investigated how cerebellar transcranial direct current stimulation (Cb-tDCS) modulates sensory processing both locally in Crus I/II and distally in primary somatosensory cortex (S1) in awake mice.
📄 www.biorxiv.org/content/10.1...
Cerebellar tDCS differentially modulates sensory inputs in somatosensory cortex and cerebellum
Cerebellar transcranial direct-current stimulation (Cb-tDCS) is a promising tool for non-invasive modulation of cerebellar activity and has been proposed for the treatment of cerebellum-related disord...
www.biorxiv.org
June 30, 2025 at 9:17 AM
Reposted by Carlos A. Sánchez León
conchilillo.bsky.social
Como hay gente que cree que es un truco o que os os estoy engañando, aquí tenéis un frame del vídeo. Mide las rayas de colores, de un extremo a otro (sin tener en cuenta las puntas de flecha). Cualquiera de ellas. Son todas iguales, compruébalo
June 29, 2025 at 1:40 PM
Reposted by Carlos A. Sánchez León
biorxiv-neursci.bsky.social
Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity https://www.biorxiv.org/content/10.1101/2025.06.27.662081v1
June 29, 2025 at 12:15 AM
Reposted by Carlos A. Sánchez León
neural-reckoning.org
Very happy to see this message that science publishers are not only a waste of money, but are actually distorting the scientific process itself, slowing down progress. This has been the key argument for me for a while. The waste of resources is bad, but the distortion of science is unforgivable.
georgealfredcurrie.bsky.social George Currie @georgealfredcurrie.bsky.social · May 19
Does publishing serve science or is science serving publishing?

Damian Pattinson and I (@elife.bsky.social) argue scientific publishing has evolved into a system that, rather than facilitate scholarly communication, distorts and dictates it.

onlinelibrary.wiley.com/doi/10.1002/...

#OpenScience
Screenshot of article summary of: Toward Science-Led Publishing by Damian Pattinson, George Currie published as an opinion piece, in Learned Publishing Summary The current dynamic of scholarly publishing prioritises the wants of the publishing industry over the needs of the research community. This article explores this theme through the lens of ‘publisher-led science’ as a description of our current status quo, and through ‘science-led publishing’ as an improved future state. We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress. We propose three elements of a science-led publishing approach that would accelerate research communication, incentivise collaboration between authors, editors and reviewers, and create a more transparent and equitable research landscape. We believe that research funding and research assessment are two of the primary levers for wider change in research and research culture and consider the future purpose of scholarly publishing in a world where these proposals have been widely adopted.
May 22, 2025 at 8:36 PM
Reposted by Carlos A. Sánchez León
zeigerlab.bsky.social
Really cool new science from the Portera-Cailliau lab on the neural circuit basis of social touch avoidance in a mouse model of Fragile X Syndrome. link.springer.com/article/10.1...
A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism - Nature Communications
Social touch is critical for communication to impart emotions and intentions. However, certain autistic individuals experience aversion to social touch. Here, we used Neuropixels probes to record neur...
link.springer.com
May 20, 2025 at 4:11 AM
Reposted by Carlos A. Sánchez León
elabrazodeloso.bsky.social
🎙️ En el episodio de @elabrazodeloso.bsky.social de esta semana volvemos a nuestra serie sobre Botánica y lo hacemos con dos elementos fundamentales en nuestro viaje hacia el conocimiento más profundo del mundo natural 🌱

#ElAbrazodelOso #Podcast #iVooxOriginals #Botánica
May 11, 2025 at 6:51 AM
Reposted by Carlos A. Sánchez León
andrush05.bsky.social
www.biorxiv.org/content/10.1...
Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.
Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type...
www.biorxiv.org
April 25, 2025 at 8:18 PM
Reposted by Carlos A. Sánchez León
jguallar.bsky.social
La neurociencia de la desinformación @theconversation.com

ttps://theconversation.com/la-neurociencia-de-la-desinformacion-255121?utm_medium=article_clipboard_share&utm_source=theconversation.com
La neurociencia de la desinformación
¿Cómo decide nuestro cerebro si compartimos o no desinformación? Una investigación reciente relacionada con los circuitos neuronales sugiere que la desinformación cumple una función social, y que comp...
theconversation.com
April 24, 2025 at 6:38 AM
carlosasleon.bsky.social
Finally out! Check my previous thread for a quick look:
bsky.app/profile/carl...

In @elife.bsky.social: Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice doi.org/10.7554/eLif...
April 21, 2025 at 9:07 PM
carlosasleon.bsky.social
PREPRINT🚨Ever wonder how electrical⚡️ stimulation of the brain🧠modulates neuronal activity? Are you working with brain stim and variability makes you want to smash your pc and go to a mountain to grow tomatoes? Are you a family member or a friend who really appreciate me? 1/13
a man in a red shirt and black gloves is holding a box with the word success on it
ALT: a man in a red shirt and black gloves is holding a box with the word success on it
media.tenor.com
April 15, 2025 at 5:10 PM