In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
And why did it work? I’ve no idea.
And why did it work? I’ve no idea.
"But now it's just another show, You leave'em laughing when you go "
"But now it's just another show, You leave'em laughing when you go "
it took a while, but now the ORCA 6.0 article is out! It serves as generic reference for ORCA 6.x. However, if you are serious about supporting our efforts, please take note of the suggested citations at the end of each ORCA run.
wires.onlinelibrary.wiley.com/doi/10.1002/...
it took a while, but now the ORCA 6.0 article is out! It serves as generic reference for ORCA 6.x. However, if you are serious about supporting our efforts, please take note of the suggested citations at the end of each ORCA run.
wires.onlinelibrary.wiley.com/doi/10.1002/...
@canvasblue.bsky.social
(won’t work in this case though)
Also this review is really good
pubs.acs.org/doi/10.1021/...
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...