Benjamín Cartes-Saavedra
@btcartes.bsky.social
Mitochondrial Biologist. Postdoctoral Research Fellow at MitoCare, Thomas Jefferson University.
Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development
Berezhnaya et al. showed that MICU2 is present in the brain during development but
is replaced during maturation by MICU3. MICU2 loss during development results in neuronal
overmigration in the cortex...
www.cell.com
November 24, 2025 at 8:39 PM
Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
Reposted by Benjamín Cartes-Saavedra
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1
April 4, 2025 at 11:30 AM
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1
Reposted by Benjamín Cartes-Saavedra
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:42 PM
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Happy to share this research paper in where I had the opportunity to contribute! Click below to read more about the dependence of mitochondrial calcium signaling and mitochondrial fusion dynamics on the IMS dissagregase CLPB
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB - Nature Communications
CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca2+ han...
www.nature.com
March 22, 2025 at 4:38 AM
Happy to share this research paper in where I had the opportunity to contribute! Click below to read more about the dependence of mitochondrial calcium signaling and mitochondrial fusion dynamics on the IMS dissagregase CLPB
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Benjamín Cartes-Saavedra
Watching axons on the move
Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...
Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...
March 19, 2025 at 9:01 PM
Watching axons on the move
Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...
Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...
Reposted by Benjamín Cartes-Saavedra
Quality control of mitochondrial nucleoids
Quality control of mitochondrial nucleoids
Mitochondrial nucleoids, organized complexes that house and protect mitochondrial DNA (mtDNA), are normally confined within the mitochondrial double-membrane system. Under cellular stress conditions, particularly oxidative and inflammatory stress, these…
dlvr.it
March 8, 2025 at 4:45 PM
Quality control of mitochondrial nucleoids
👏🏽👏🏽👏🏽
Congratulations to Pamela Rojas de Santiago on her paper in
@Nature_NPJ Precision Oncology showing LINE-1 ORF1p expression in clear cell ovarian cancer precursors (endometriosis) and detection in patient samples. 🎉 rdcu.be/ecv6k
@powelldrescher.bsky.social @tinaswish.bsky.social @srocf.bsky.social
@Nature_NPJ Precision Oncology showing LINE-1 ORF1p expression in clear cell ovarian cancer precursors (endometriosis) and detection in patient samples. 🎉 rdcu.be/ecv6k
@powelldrescher.bsky.social @tinaswish.bsky.social @srocf.bsky.social
LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker
npj Precision Oncology - LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker
rdcu.be
March 18, 2025 at 11:36 AM
👏🏽👏🏽👏🏽
Our last review from Hajnoczky Lab! It is a comprehensive view about the different roles of mitochondria in global al local calcium signals
March 18, 2025 at 11:26 AM
Our last review from Hajnoczky Lab! It is a comprehensive view about the different roles of mitochondria in global al local calcium signals