Lindsey Goodman
@brainyfly.bsky.social
Neuroscience PhD; postdoc in the Bellen lab at BCM; neurogenetics; Drosophila; neurodegenerative diseases: AD, PiD, FTD, PSP, CBD, ALS; neuron glia communication; lipid droplets
Reposted by Lindsey Goodman
And just like that, my new award from the @StateDept to help Pakistan grapple with air pollution and climate change is no more, thanks to this new administration
January 27, 2025 at 6:01 PM
And just like that, my new award from the @StateDept to help Pakistan grapple with air pollution and climate change is no more, thanks to this new administration
Reposted by Lindsey Goodman
#APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉
So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology - Molecular Neurodegeneration
Background Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch...
molecularneurodegeneration.biomedcentral.com
January 22, 2025 at 10:57 PM
#APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉
So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉
Reposted by Lindsey Goodman
GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq
Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying mos...
www.biorxiv.org
January 26, 2025 at 12:13 AM
GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
Reposted by Lindsey Goodman
New pre-print: an one-stop shop for everything you wanted to know about the fly olfactory system: www.biorxiv.org/content/10.1...
An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system
The Drosophila melanogaster olfactory system is one of the most intensively studied parts of the nervous system in any animal. Composed of ~60 independent olfactory neuron classes, with several associ...
www.biorxiv.org
January 17, 2025 at 9:39 AM
New pre-print: an one-stop shop for everything you wanted to know about the fly olfactory system: www.biorxiv.org/content/10.1...