Translational Psychiatry - Addressing social determinants of health in individuals with mental disorders in clinical practice: review and recommendations

A US panel’s decision not to recommend the preservative thiomersal won’t affect vaccine availability in Australia, say experts. But it will stoke dangerous anti-vax sentiment

Dame Rachel De Souza calls on billionaire owner of social media site to ‘act like a father’ and protect youngsters

In February, the highest month for suspensions this year, for every minute, more than one recipient had their payments paused

This Viewpoint discusses the global challenge of defining diseases and the need to balance broader access to medical treatment with avoidance of harmful medicaliziation and inefficient resource use.

The origin of SARS-CoV-2 has been intensely scrutinized, and epidemiological and genomic evidence has consistently pointed to Wuhan’s Huanan Seafood Wholesale Market as the epicenter of the COVID-19 pandemic. Early cases were associated with this market, and environmental sequencing placed the common ancestor of SARS-CoV-2 genomic diversity within the market. Phylogenetic analysis also suggested separate introductions of lineages A and B into the human population, a finding that can be tested with additional data. Here, we curated an expanded sequence dataset of early SARS-CoV-2 viral genomes, including newly available sequences from mid-January 2020. In this dataset, we found no additional support for previously proposed alternative progenitor sequences, or for any evolutionary intermediates between lineages A and B in the human population. Instead, we identified SARS-CoV-2 lineages that may have spread from the market, and additional samples of a sublineage of lineage A with three mutations, including one found in closely related bat coronaviruses. Although our analysis of early pandemic genomes suggests that this mutation is unlikely to characterize the immediate SARS-CoV-2 ancestor, it is more plausible than two previously proposed ancestral genomes. These findings reinforce the proposed emergence of SARS-CoV-2 from the wildlife trade at the Huanan market, demonstrating how new data continues to both solidify and clarify our understanding of how the pandemic began. ### Competing Interest Statement The authors have declared no competing interest.

A volcanic eruption in Iceland has triggered an evacuation near the nation's capital.

Governor Ron DeSantis leads push to loosen child labor laws as immigration crackdown leads to workforce shortage Beneath the smugness of Ron DeSantis, at Florida leading the nation in immigration enforcement lies something of a conundrum: how to fill the essential jobs of the scores of immigrant workers targeted for deportation. The answer, according to Florida lawmakers, is the state’s schoolchildren, who as young as 14 could soon be allowed to work overnight shifts without a break – even on school nights. Continue reading...

Dr Peter Marks was seen as a guardrail against any future politicisation of the FDA’s approval of life-saving vaccines A senior health official in the US, who was seen as a guardrail against any future politicisation of the Food and Drug Administration’s approval of life-saving vaccines, has resigned abruptly, citing the health secretary Robert F Kennedy Jr’s “misinformation and lies”. Dr Peter Marks served as the FDA’s top vaccine official. He had been lauded by Donald Trump during the US president’s first term for his role in Operation Warp Speed, the initiative that developed, manufactured and helped distribute the Covid-19 vaccines. Continue reading...

Six and a half million British viewers saw it in its opening week, making it the most streamed TV drama in this country so far