Singapore and Japan researchers found that aged blood stem cells with high mitochondria stay regenerative, not exhausted.

They identified GPR183 as a key marker, revealing new insights into stem cell aging

www.nature.com/articles/s43...

(1/4) In recognition of #HeartMonth, join SCN’s Joanna Valsamis as she chats with biomedical engineering expert Dr. Sara Vasconcelos (University Health Network, Toronto) about cutting-edge stem cell research for heart disease—a leading cause of death and disability in Canada.

Our NIH funded lab is developing research tools for the study of biological vascular aging. One tool is the development of pluripotent stem cells from young and older adults’ peripheral blood.
Here’s some of our recent work: www.sciencedirect.com/science/arti...

🧪 Scientists at @kidney-resrch-inst.bsky.social used human kidney #organoids to test a potential new treatment for polycystic kidney disease (PKD), a currently incurable disorder. Paper by Gulieva, Ahmadvand, & Freedman in @isscr.org Stem Cell Reports: www.cell.com/stem-cell-re...

Long-lived plants and animals clearly regulate their physiology according to seasonal changes in day length to appropriately adjust their physiology. A new study shows that cyanobacteria can do the same even though individuals only live for a few hours. #Science

www.science.org/doi/10.1126/...

Excited to share this collaboration with @tcuellargaviria.bsky.social, @nhc-nanomedlab.bsky.social, and Dan Wozniak showing the potential of our Tissue Nano-Transfection (#TNT) technology and tissue-derived extracellular vesicles to combat biofilm infections.
www.sciencedirect.com/science/arti...

SARS-CoV-2 Envelope Protein Generates Unique Extracellular Vesicles, which appear to be an important mechanism helping SARS-CoV-2 to facilitate its spread, replicate efficiently, and evade host immune responses
https://buff.ly/4g30AHS

So, it turns out one of our favourite extracellular vesicle lipid raft proteins, Flotillin-1 (FLOT1), is actually shaped like a basket 🧺

www.pnas.org/doi/10.1073/...

#extracellularvesicles

One can isolate #ExtracellularVesicle from🐭Bone (tibia/femur, not bone marrow)!?😮

Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭

Matrix Biol 2024
www.sciencedirect.com/science/arti...

Benjamin Ryskeldi-Falcon’s @brfalcon.bsky.social group in the LMB’s Neurobiology Division, with Karen Duff's group at the UK DRI, have discovered that tau filaments are tethered to the membranes of extracellular vesicles in #Alzheimers

Read more: www2.mrc-lmb.cam.ac.uk/cryo-et-reve...
#LMBResearch

COVID-19 Study Links Extracellular Vesicles to Severe Outcomes

www.thailandmedical.news/news/covid-1...

This week #rEView is featuring the last #podcast in the series leading up to #ISEVxTech!

David Freedman and George Daaboul are co-founders of Everest Biolabs, specialising in workflows for #ExtracellularVesicles isolation and characterisation.

open.spotify.com/episode/3UBG...

Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens

#mBiojournal MiniReview / Mycology

journals.asm.org/doi/10.1128/...

New paper out on extracellular #vesicle (EV) mobility in #collagen I #hydrogels!
How #integrins on EV surfaces influence EV movement through tissue-like environments.

pubs.acs.org/doi/10.1021/...

Bluesky now has over 10 million users, and I was #9,738,639!