Baikuntha
@baikuntha.bsky.social
Passionate Neurologist 🧠| Exploring the brain's intricate webs |Assistant Professor, Department of Neurology,All India Institute of Medical Sciences, Deoghar, Jharkhand, India
Pinned
Baikuntha
@baikuntha.bsky.social
· Nov 15
🔥Essential Tremor-2026 update!
👉Current RCT evidence using at least a month of follow-up is insufficient to support ET medications!
👉 Better trials needed!
Wonderful work by DeepaDash
madam and team!
Full paper-https://doi.org/10.1002/mds.70184
A visual summary 👇
#EBM
👉Current RCT evidence using at least a month of follow-up is insufficient to support ET medications!
👉 Better trials needed!
Wonderful work by DeepaDash
madam and team!
Full paper-https://doi.org/10.1002/mds.70184
A visual summary 👇
#EBM
February 14, 2026 at 9:24 AM
🔥Essential Tremor-2026 update!
👉Current RCT evidence using at least a month of follow-up is insufficient to support ET medications!
👉 Better trials needed!
Wonderful work by DeepaDash
madam and team!
Full paper-https://doi.org/10.1002/mds.70184
A visual summary 👇
#EBM
👉Current RCT evidence using at least a month of follow-up is insufficient to support ET medications!
👉 Better trials needed!
Wonderful work by DeepaDash
madam and team!
Full paper-https://doi.org/10.1002/mds.70184
A visual summary 👇
#EBM
🔥A new ray of hope for PPMS!
The FENtrepid results comparing Fenebrutinib vs ocrelizumab are so encouraging!
The wonderful podcast👇
ectrims.eu/podcast/episod…
And a summary 👇
The FENtrepid results comparing Fenebrutinib vs ocrelizumab are so encouraging!
The wonderful podcast👇
ectrims.eu/podcast/episod…
And a summary 👇
February 9, 2026 at 12:13 PM
🔥A new ray of hope for PPMS!
The FENtrepid results comparing Fenebrutinib vs ocrelizumab are so encouraging!
The wonderful podcast👇
ectrims.eu/podcast/episod…
And a summary 👇
The FENtrepid results comparing Fenebrutinib vs ocrelizumab are so encouraging!
The wonderful podcast👇
ectrims.eu/podcast/episod…
And a summary 👇
🔥OCEANIC charts a safer course in Stroke prevention🌊
👉Asundexian 50 mg OD ↓ ischemic stroke 6.2% vs 8.4% (HR 0.74, 95% CI 0.65–0.84, p<0.001)
👉No significant increase in major/clinically relevant non-major/minor intracranial bleeding!
👇
clinicaltrialresults.org
Summary 👇
👉Asundexian 50 mg OD ↓ ischemic stroke 6.2% vs 8.4% (HR 0.74, 95% CI 0.65–0.84, p<0.001)
👉No significant increase in major/clinically relevant non-major/minor intracranial bleeding!
👇
clinicaltrialresults.org
Summary 👇
February 6, 2026 at 6:41 PM
🔥OCEANIC charts a safer course in Stroke prevention🌊
👉Asundexian 50 mg OD ↓ ischemic stroke 6.2% vs 8.4% (HR 0.74, 95% CI 0.65–0.84, p<0.001)
👉No significant increase in major/clinically relevant non-major/minor intracranial bleeding!
👇
clinicaltrialresults.org
Summary 👇
👉Asundexian 50 mg OD ↓ ischemic stroke 6.2% vs 8.4% (HR 0.74, 95% CI 0.65–0.84, p<0.001)
👉No significant increase in major/clinically relevant non-major/minor intracranial bleeding!
👇
clinicaltrialresults.org
Summary 👇
🔥An "OPTION" of thrombolysing non LVOs beyond 4.5hrs with Tenecteplase with perfusion imaging ❗
Hot off the JAMA press!
👉📊 Non-LVO stroke (4.5–24h):
👉Tenecteplase ↑ mRS 0–1 RR 1.28 (95%CI 1.04–1.57)
⚠️ sICH 2.8% vs 0%.
Full paper:10.1001/jama.2026.0210
A visual summary 👇
Hot off the JAMA press!
👉📊 Non-LVO stroke (4.5–24h):
👉Tenecteplase ↑ mRS 0–1 RR 1.28 (95%CI 1.04–1.57)
⚠️ sICH 2.8% vs 0%.
Full paper:10.1001/jama.2026.0210
A visual summary 👇
February 6, 2026 at 1:33 PM
🔥An "OPTION" of thrombolysing non LVOs beyond 4.5hrs with Tenecteplase with perfusion imaging ❗
Hot off the JAMA press!
👉📊 Non-LVO stroke (4.5–24h):
👉Tenecteplase ↑ mRS 0–1 RR 1.28 (95%CI 1.04–1.57)
⚠️ sICH 2.8% vs 0%.
Full paper:10.1001/jama.2026.0210
A visual summary 👇
Hot off the JAMA press!
👉📊 Non-LVO stroke (4.5–24h):
👉Tenecteplase ↑ mRS 0–1 RR 1.28 (95%CI 1.04–1.57)
⚠️ sICH 2.8% vs 0%.
Full paper:10.1001/jama.2026.0210
A visual summary 👇
🔥EMPHASIS now on the Neurovascular Unit 🤔
🧠Neuroprotection ≠ neurons alone.
💊 Minocycline within 72 h of ischaemic stroke increased mRS 0–1 at 90 days (52.6% vs 47.4%; adjusted RR 1.11, 95% CI 1.03–1.20)
Check out 👇
doi.org/10.1016/S014...
A summary 👇
🧠Neuroprotection ≠ neurons alone.
💊 Minocycline within 72 h of ischaemic stroke increased mRS 0–1 at 90 days (52.6% vs 47.4%; adjusted RR 1.11, 95% CI 1.03–1.20)
Check out 👇
doi.org/10.1016/S014...
A summary 👇
February 3, 2026 at 9:47 AM
🔥EMPHASIS now on the Neurovascular Unit 🤔
🧠Neuroprotection ≠ neurons alone.
💊 Minocycline within 72 h of ischaemic stroke increased mRS 0–1 at 90 days (52.6% vs 47.4%; adjusted RR 1.11, 95% CI 1.03–1.20)
Check out 👇
doi.org/10.1016/S014...
A summary 👇
🧠Neuroprotection ≠ neurons alone.
💊 Minocycline within 72 h of ischaemic stroke increased mRS 0–1 at 90 days (52.6% vs 47.4%; adjusted RR 1.11, 95% CI 1.03–1.20)
Check out 👇
doi.org/10.1016/S014...
A summary 👇
❗How do you manage acute migraine attacks in the ED? 🚑
The AHS guidelines are here!
IV prochlorperazine & GON block = top choices.
IV Opioids & IV paracetamol ❌
-A look at the full paper-https://doi.org/10.1111/head.70016
-And the visual summary here👇
#Migraine
The AHS guidelines are here!
IV prochlorperazine & GON block = top choices.
IV Opioids & IV paracetamol ❌
-A look at the full paper-https://doi.org/10.1111/head.70016
-And the visual summary here👇
#Migraine
February 1, 2026 at 1:29 PM
❗How do you manage acute migraine attacks in the ED? 🚑
The AHS guidelines are here!
IV prochlorperazine & GON block = top choices.
IV Opioids & IV paracetamol ❌
-A look at the full paper-https://doi.org/10.1111/head.70016
-And the visual summary here👇
#Migraine
The AHS guidelines are here!
IV prochlorperazine & GON block = top choices.
IV Opioids & IV paracetamol ❌
-A look at the full paper-https://doi.org/10.1111/head.70016
-And the visual summary here👇
#Migraine
🤔Should you thrombolyse an Acute CRAO?
🔴The TenCRAOS tells us not to!
Have a look at the full trial results:👇
www.nejm.org/doi/full/10....
And a summary here👇
🔴The TenCRAOS tells us not to!
Have a look at the full trial results:👇
www.nejm.org/doi/full/10....
And a summary here👇
January 29, 2026 at 5:47 PM
🤔Should you thrombolyse an Acute CRAO?
🔴The TenCRAOS tells us not to!
Have a look at the full trial results:👇
www.nejm.org/doi/full/10....
And a summary here👇
🔴The TenCRAOS tells us not to!
Have a look at the full trial results:👇
www.nejm.org/doi/full/10....
And a summary here👇
🔥🧠The much needed 2026 AHA/ASA guidelines on Acute Ischemic Stroke are out!
Check out the paper👇
doi.org/10.1161/STR....
and key takeaways:-
Check out the paper👇
doi.org/10.1161/STR....
and key takeaways:-
January 26, 2026 at 6:47 PM
🔥🧠The much needed 2026 AHA/ASA guidelines on Acute Ischemic Stroke are out!
Check out the paper👇
doi.org/10.1161/STR....
and key takeaways:-
Check out the paper👇
doi.org/10.1161/STR....
and key takeaways:-
🤔 Do steroids improve outcomes in adult HSV encephalitis?
👉DexEnceph RCT (n=94, UK): dexamethasone + acyclovir vs acyclovir alone.
🔑No improvement in verbal memory at 26 weeks (Δ 1.77; p=0.76).
❗Steroids safe, but no cognitive benefit.
Link:https://doi.org/10.1016/S1474-4422(25)00454-5
👉DexEnceph RCT (n=94, UK): dexamethasone + acyclovir vs acyclovir alone.
🔑No improvement in verbal memory at 26 weeks (Δ 1.77; p=0.76).
❗Steroids safe, but no cognitive benefit.
Link:https://doi.org/10.1016/S1474-4422(25)00454-5
January 24, 2026 at 6:30 AM
🤔 Do steroids improve outcomes in adult HSV encephalitis?
👉DexEnceph RCT (n=94, UK): dexamethasone + acyclovir vs acyclovir alone.
🔑No improvement in verbal memory at 26 weeks (Δ 1.77; p=0.76).
❗Steroids safe, but no cognitive benefit.
Link:https://doi.org/10.1016/S1474-4422(25)00454-5
👉DexEnceph RCT (n=94, UK): dexamethasone + acyclovir vs acyclovir alone.
🔑No improvement in verbal memory at 26 weeks (Δ 1.77; p=0.76).
❗Steroids safe, but no cognitive benefit.
Link:https://doi.org/10.1016/S1474-4422(25)00454-5
🔥 Hot off Cell Press! 🧠🗣️
Did you know the cerebellum has a language-selective region?
This new fMRI study(n=800+) says so!
👉LangCereb3 is highly language-selective❗
🤔Time to start looking for LangCereb3 aphasias?
Check this out👇
doi.org/10.1016/j.ne...
#Cerebellum
#Aphasia
Did you know the cerebellum has a language-selective region?
This new fMRI study(n=800+) says so!
👉LangCereb3 is highly language-selective❗
🤔Time to start looking for LangCereb3 aphasias?
Check this out👇
doi.org/10.1016/j.ne...
#Cerebellum
#Aphasia
January 23, 2026 at 3:36 PM
🔥 Hot off Cell Press! 🧠🗣️
Did you know the cerebellum has a language-selective region?
This new fMRI study(n=800+) says so!
👉LangCereb3 is highly language-selective❗
🤔Time to start looking for LangCereb3 aphasias?
Check this out👇
doi.org/10.1016/j.ne...
#Cerebellum
#Aphasia
Did you know the cerebellum has a language-selective region?
This new fMRI study(n=800+) says so!
👉LangCereb3 is highly language-selective❗
🤔Time to start looking for LangCereb3 aphasias?
Check this out👇
doi.org/10.1016/j.ne...
#Cerebellum
#Aphasia
🛑Honest answers‼️
🥱 How often do you assess fatigue in individuals with Parkinson’s Disease(PD)❓
❓ Do you think everyone who feels tired is truly fatigued❓
🛑 Did you know PD has a unique "Park Fatigue" subtype❓
📌Check out our latest paper. #Neurosky #Fatigue
journals.lww.com/aomd/fulltex...
🥱 How often do you assess fatigue in individuals with Parkinson’s Disease(PD)❓
❓ Do you think everyone who feels tired is truly fatigued❓
🛑 Did you know PD has a unique "Park Fatigue" subtype❓
📌Check out our latest paper. #Neurosky #Fatigue
journals.lww.com/aomd/fulltex...
Fatigue in Parkinson’s disease—A narrative review : Annals of Movement Disorders
nce, and depression. However, considering the effects of fatigue on the quality of life (QoL) of individuals with PD, it is crucial to review its causes and management strategies. According to the dia...
journals.lww.com
December 22, 2024 at 4:39 AM
🛑Honest answers‼️
🥱 How often do you assess fatigue in individuals with Parkinson’s Disease(PD)❓
❓ Do you think everyone who feels tired is truly fatigued❓
🛑 Did you know PD has a unique "Park Fatigue" subtype❓
📌Check out our latest paper. #Neurosky #Fatigue
journals.lww.com/aomd/fulltex...
🥱 How often do you assess fatigue in individuals with Parkinson’s Disease(PD)❓
❓ Do you think everyone who feels tired is truly fatigued❓
🛑 Did you know PD has a unique "Park Fatigue" subtype❓
📌Check out our latest paper. #Neurosky #Fatigue
journals.lww.com/aomd/fulltex...
🧠Case Alert‼️ #Neurosky #Neurocase
1/🤔A 52yr old man comes in with a history of intermittent left sided headaches a/w vomiting+B/L 👀vision loss (unclear onset)+Slowly progressive hearing👂loss in right ear since 2006.
1/🤔A 52yr old man comes in with a history of intermittent left sided headaches a/w vomiting+B/L 👀vision loss (unclear onset)+Slowly progressive hearing👂loss in right ear since 2006.
a man in a zebra print sweater is holding a cup of coffee and says what 's going on
ALT: a man in a zebra print sweater is holding a cup of coffee and says what 's going on
media.tenor.com
December 16, 2024 at 6:40 PM
🧠Case Alert‼️ #Neurosky #Neurocase
1/🤔A 52yr old man comes in with a history of intermittent left sided headaches a/w vomiting+B/L 👀vision loss (unclear onset)+Slowly progressive hearing👂loss in right ear since 2006.
1/🤔A 52yr old man comes in with a history of intermittent left sided headaches a/w vomiting+B/L 👀vision loss (unclear onset)+Slowly progressive hearing👂loss in right ear since 2006.
❓How do you assess Autonomic nervous system(ANS) at the bedside?
🛑Do you just test for OH and say everything is fine?
🤔What if I told you every axis of the ANS can be tested 🥽 with minimal equipment?
🧾Check out our latest paper to get answers.
doi.org/10.1007/s137...
🛑Do you just test for OH and say everything is fine?
🤔What if I told you every axis of the ANS can be tested 🥽 with minimal equipment?
🧾Check out our latest paper to get answers.
doi.org/10.1007/s137...
Examination of the autonomic nervous system at the bedside - Acta Neurologica Belgica
Autonomic function is an integral part of the assessment of neurological disorders. However, pragmatically, it is often the most neglected part of neurological examination and is often limited to test...
doi.org
December 6, 2024 at 4:15 PM
❓How do you assess Autonomic nervous system(ANS) at the bedside?
🛑Do you just test for OH and say everything is fine?
🤔What if I told you every axis of the ANS can be tested 🥽 with minimal equipment?
🧾Check out our latest paper to get answers.
doi.org/10.1007/s137...
🛑Do you just test for OH and say everything is fine?
🤔What if I told you every axis of the ANS can be tested 🥽 with minimal equipment?
🧾Check out our latest paper to get answers.
doi.org/10.1007/s137...
🧠 storming!
A 60yr old comes in with acute onset drowsiness,left 7th,9th,10th and 12th cranial nerve palsy. He has a history of weight loss,hematemesis,bicytopenia(anemia with thrombocytopenia). You order an imaging and see this.
A 60yr old comes in with acute onset drowsiness,left 7th,9th,10th and 12th cranial nerve palsy. He has a history of weight loss,hematemesis,bicytopenia(anemia with thrombocytopenia). You order an imaging and see this.
December 4, 2024 at 5:00 AM
🧠 storming!
A 60yr old comes in with acute onset drowsiness,left 7th,9th,10th and 12th cranial nerve palsy. He has a history of weight loss,hematemesis,bicytopenia(anemia with thrombocytopenia). You order an imaging and see this.
A 60yr old comes in with acute onset drowsiness,left 7th,9th,10th and 12th cranial nerve palsy. He has a history of weight loss,hematemesis,bicytopenia(anemia with thrombocytopenia). You order an imaging and see this.
Hi sky!
Have you ever seen a bedside elicitation of the Blink reflex? I will be providing more history of someone can say if there is a special name for this reflex or not??? Bright minds of Sky inputs needed
Have you ever seen a bedside elicitation of the Blink reflex? I will be providing more history of someone can say if there is a special name for this reflex or not??? Bright minds of Sky inputs needed
November 28, 2024 at 5:43 PM
Hi sky!
Have you ever seen a bedside elicitation of the Blink reflex? I will be providing more history of someone can say if there is a special name for this reflex or not??? Bright minds of Sky inputs needed
Have you ever seen a bedside elicitation of the Blink reflex? I will be providing more history of someone can say if there is a special name for this reflex or not??? Bright minds of Sky inputs needed
docs.google.com/forms/d/e/1F...
Hi sky!
This is an ethics approved project to know the knowledge attitude and practice of neurologists on advance care planning in PD.
Help us out by filling out the questionnaire which will take less than 3 minutes.
Your views and opinion will be kept confidential.
Hi sky!
This is an ethics approved project to know the knowledge attitude and practice of neurologists on advance care planning in PD.
Help us out by filling out the questionnaire which will take less than 3 minutes.
Your views and opinion will be kept confidential.
docs.google.com
November 20, 2024 at 12:26 PM
docs.google.com/forms/d/e/1F...
Hi sky!
This is an ethics approved project to know the knowledge attitude and practice of neurologists on advance care planning in PD.
Help us out by filling out the questionnaire which will take less than 3 minutes.
Your views and opinion will be kept confidential.
Hi sky!
This is an ethics approved project to know the knowledge attitude and practice of neurologists on advance care planning in PD.
Help us out by filling out the questionnaire which will take less than 3 minutes.
Your views and opinion will be kept confidential.
🔗🛑Parakinesia Brachialis Oscitans
🥱Yawning-induced paretic arm movement occurs in pyramidal tract lesions(internal capsule, pons).
⚠️autonomic-voluntary dissociation.
🧠Corticopontocerebellar inhibition loss.
❓Seen in stroke, tumefactive lesions.
www.ahajournals.org/doi/10.1161/...
🥱Yawning-induced paretic arm movement occurs in pyramidal tract lesions(internal capsule, pons).
⚠️autonomic-voluntary dissociation.
🧠Corticopontocerebellar inhibition loss.
❓Seen in stroke, tumefactive lesions.
www.ahajournals.org/doi/10.1161/...
Parakinesia Brachialis Oscitans: Old Sign, New Findings | Stroke
www.ahajournals.org
November 17, 2024 at 7:33 AM
🔗🛑Parakinesia Brachialis Oscitans
🥱Yawning-induced paretic arm movement occurs in pyramidal tract lesions(internal capsule, pons).
⚠️autonomic-voluntary dissociation.
🧠Corticopontocerebellar inhibition loss.
❓Seen in stroke, tumefactive lesions.
www.ahajournals.org/doi/10.1161/...
🥱Yawning-induced paretic arm movement occurs in pyramidal tract lesions(internal capsule, pons).
⚠️autonomic-voluntary dissociation.
🧠Corticopontocerebellar inhibition loss.
❓Seen in stroke, tumefactive lesions.
www.ahajournals.org/doi/10.1161/...
Will CAR-T cells be used in MS anytime soon considering their amazing success in oncology??Honest opinions?? Have a look at this paper...
www.sciencedirect.com/science/arti... Have provided a short AV summary.
www.sciencedirect.com/science/arti... Have provided a short AV summary.
November 16, 2024 at 5:57 PM
Will CAR-T cells be used in MS anytime soon considering their amazing success in oncology??Honest opinions?? Have a look at this paper...
www.sciencedirect.com/science/arti... Have provided a short AV summary.
www.sciencedirect.com/science/arti... Have provided a short AV summary.
Reposted by Baikuntha
There are some journal starter packs! This list searched the keyword "medical". You might have to scroll a bit, but they are there.
blueskydirectory.com/starter-pack...
blueskydirectory.com/starter-pack...
All - Bluesky Directory
A curated collection of all things relating to the Blue Sky social media platform.
blueskydirectory.com
November 16, 2024 at 2:15 PM
There are some journal starter packs! This list searched the keyword "medical". You might have to scroll a bit, but they are there.
blueskydirectory.com/starter-pack...
blueskydirectory.com/starter-pack...
❓When do you order 🧬GENETIC studies in a case of DYSTONIA-ATAXIA syndrome with abnormal 👀EYE movements?
Does a NEGATIVE test for REPEAT expansions rule out genetic ataxias or you wanna dig further?
Check out our #Clinical reasoning in #RFS Neurology
10.1212/WNL.0000000000210046
Does a NEGATIVE test for REPEAT expansions rule out genetic ataxias or you wanna dig further?
Check out our #Clinical reasoning in #RFS Neurology
10.1212/WNL.0000000000210046
November 15, 2024 at 4:26 PM
❗ Biomarkers ≠Alzheimer Disease
Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era.
doi:10.1001/jamaneurol.2024.3770
🧠AD is a Clinico-biologic Construct and not a biomarker diagnosis.
My short summary.
#biomarkers
#Lexicon
#Alzheimer disease.
Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era.
doi:10.1001/jamaneurol.2024.3770
🧠AD is a Clinico-biologic Construct and not a biomarker diagnosis.
My short summary.
#biomarkers
#Lexicon
#Alzheimer disease.
November 15, 2024 at 2:54 PM
❗ Biomarkers ≠Alzheimer Disease
Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era.
doi:10.1001/jamaneurol.2024.3770
🧠AD is a Clinico-biologic Construct and not a biomarker diagnosis.
My short summary.
#biomarkers
#Lexicon
#Alzheimer disease.
Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era.
doi:10.1001/jamaneurol.2024.3770
🧠AD is a Clinico-biologic Construct and not a biomarker diagnosis.
My short summary.
#biomarkers
#Lexicon
#Alzheimer disease.