Aoon Rizvi
@aoonr.bsky.social
Propel Postdoctoral Fellow at Stanford. Interested in chromatin structure, LLPS, condensate structures.
Reposted by Aoon Rizvi
New in JACS! Using NMR, we show how condensates selectively bind and localize ions following the 'law of matching water affinities', shaping condensate composition, interface potential & RNA stability.
Read about it here: doi.org/10.1021/jacs.5c07295
@irissmokers.bsky.social
Read about it here: doi.org/10.1021/jacs.5c07295
@irissmokers.bsky.social
Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates
Biomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. To understand these processes, it is essential to...
doi.org
July 16, 2025 at 7:41 AM
New in JACS! Using NMR, we show how condensates selectively bind and localize ions following the 'law of matching water affinities', shaping condensate composition, interface potential & RNA stability.
Read about it here: doi.org/10.1021/jacs.5c07295
@irissmokers.bsky.social
Read about it here: doi.org/10.1021/jacs.5c07295
@irissmokers.bsky.social
Reposted by Aoon Rizvi
My last three students at Illinois. Congratulations to Dr. Joel Roberts, Dr. Nafisa Ibrahim (co-advised by @jrl-electrochem.bsky.social), and Astarte Abbott. Three amazing students with a bright careers ahead!
May 21, 2025 at 5:55 PM
My last three students at Illinois. Congratulations to Dr. Joel Roberts, Dr. Nafisa Ibrahim (co-advised by @jrl-electrochem.bsky.social), and Astarte Abbott. Three amazing students with a bright careers ahead!
Reposted by Aoon Rizvi
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
rdcu.be
June 17, 2025 at 3:26 AM
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Reposted by Aoon Rizvi
(Longish thread. Apologies)
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
June 8, 2025 at 6:53 PM
(Longish thread. Apologies)
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
Reposted by Aoon Rizvi
Introducing Mpipi-Recharged🔥🔥🔥
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates
Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...
pubs.acs.org
February 11, 2025 at 1:31 PM
Introducing Mpipi-Recharged🔥🔥🔥
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Reposted by Aoon Rizvi
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Hello science bluesky! Excited to be part of The Rising Stars in Soft and Biological Matter Symposium along with so many amazing scientists! Register here to attend this virtual symposium next week! mrsec.uchicago.edu/educational-...
Rising Stars symposium
The Rising Stars in Soft and Biological Matter Symposium, co-sponsored by UChicago and the University of California San Diego MRSECs, provides a platform for exceptional early-career soft and biologic...
mrsec.uchicago.edu
December 4, 2024 at 5:46 PM
Hello science bluesky! Excited to be part of The Rising Stars in Soft and Biological Matter Symposium along with so many amazing scientists! Register here to attend this virtual symposium next week! mrsec.uchicago.edu/educational-...