@annaliiiiiiii.bsky.social
Checkout this really cool di-gembodies 💎✨(aka di-gluebodies) technology by my colleague Mingda Ye and friends Gangshun and Dimitrios. By glueing two nanobodies together🔗, they managed to increase the size of protein complexes which helped to achive high resolution reconstructions 🔬🥶🔬🥶🔬🥶
Di-Gembodies (dimerized nanobodies) for improved and duplexed CryoEM of small and challenging targets!
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM - Nature Chemical Biology
Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely...
www.nature.com
August 15, 2025 at 1:55 PM
Checkout this really cool di-gembodies 💎✨(aka di-gluebodies) technology by my colleague Mingda Ye and friends Gangshun and Dimitrios. By glueing two nanobodies together🔗, they managed to increase the size of protein complexes which helped to achive high resolution reconstructions 🔬🥶🔬🥶🔬🥶
Reposted
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
www.mdc-berlin.de
August 4, 2025 at 10:23 AM
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
Reposted
Opportunity for computational chemist at Syngenta (Bracknell UK) #agrochem #CompChem #cheminformatics #AI #ML #UKChemJobs #ChemJobs #chemsky 🧪
jobs.syngenta.com/job/principa...
jobs.syngenta.com/job/principa...
Principal Scientist - Computational Chemistry
jobs.syngenta.com
July 1, 2025 at 6:32 AM
Opportunity for computational chemist at Syngenta (Bracknell UK) #agrochem #CompChem #cheminformatics #AI #ML #UKChemJobs #ChemJobs #chemsky 🧪
jobs.syngenta.com/job/principa...
jobs.syngenta.com/job/principa...
Reposted
Join our group in the Centre for Medicines Discovery at Oxford Univ. @cmd.ox.ac.uk @ox.ac.uk !!!!
Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecru...
Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecru...
June 3, 2025 at 11:18 AM
Join our group in the Centre for Medicines Discovery at Oxford Univ. @cmd.ox.ac.uk @ox.ac.uk !!!!
Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecru...
Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecru...
Reposted
Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness
www.hhmi.org/news/sc...
Explore the structures in 3D at RCSB PDB:
go.rutgers.edu/6ggjdnag
www.hhmi.org/news/sc...
Explore the structures in 3D at RCSB PDB:
go.rutgers.edu/6ggjdnag
Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness | HHMI
HHMI Investigator Charles Zuker and his lab are exploring how detection – of a taste or other sense – is transformed into perception.
www.hhmi.org
May 20, 2025 at 7:12 PM
Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness
www.hhmi.org/news/sc...
Explore the structures in 3D at RCSB PDB:
go.rutgers.edu/6ggjdnag
www.hhmi.org/news/sc...
Explore the structures in 3D at RCSB PDB:
go.rutgers.edu/6ggjdnag
Reposted
look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 11:45 PM
look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!
Reposted
Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich
Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others
www.nature.com/articles/s41...
Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others
www.nature.com/articles/s41...
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 - Nature Communications
SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanism...
www.nature.com
January 16, 2025 at 6:17 PM
Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich
Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others
www.nature.com/articles/s41...
Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others
www.nature.com/articles/s41...
Reposted
Pretty excited about this work looking at high-resolution mechanisms involved in the autoimmune disease myasthenia gravis! Please read our pre-print :D www.biorxiv.org/content/10.1...
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures
Skeletal muscle contraction is mediated by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at neuromuscular junctions. In myasthenia gravis (MG), autoantibodies target AChRs, disruptin...
www.biorxiv.org
December 21, 2024 at 7:30 PM
Pretty excited about this work looking at high-resolution mechanisms involved in the autoimmune disease myasthenia gravis! Please read our pre-print :D www.biorxiv.org/content/10.1...
Reposted
Now online! Anna’s fantastic work on the structure of the Human adult Muscle-type nicotinic receptor.
Wonderful collab with Yin Dong at the @imm.ox.ac.uk
www.biorxiv.org/content/10.1...
Wonderful collab with Yin Dong at the @imm.ox.ac.uk
www.biorxiv.org/content/10.1...
Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states
Muscle-type nicotinic acetylcholine receptor (AChR) is the key signalling molecule in neuromuscular junctions. Here we present the structures of full-length human adult receptors in complex with Fab35...
www.biorxiv.org
December 16, 2024 at 9:20 PM
Now online! Anna’s fantastic work on the structure of the Human adult Muscle-type nicotinic receptor.
Wonderful collab with Yin Dong at the @imm.ox.ac.uk
www.biorxiv.org/content/10.1...
Wonderful collab with Yin Dong at the @imm.ox.ac.uk
www.biorxiv.org/content/10.1...