Andrew E. Papale
@andrewpapale.bsky.social
Pitt Postdoc | neuroscience | decision-making | olfaction | fMRI | motor skill learning
Physics and math enthusiast. Friendly with R, Matlab, and Python.
Physics and math enthusiast. Friendly with R, Matlab, and Python.
Pinned
Excited to share a summary of a new preprint looking at exploration in ventral prefrontal cortex and hippocampus using fMRI. A 🧵...1/15
Reposted by Andrew E. Papale
@andrewpapale.bsky.social 's new explore/exploit paper in JNeurosci with @vanessabrown.bsky.social @drangelaianni.bsky.social Michael Hallquist & Bea Luna: www.jneurosci.org/content/earl...
PFC-DMN and hippocampus encode value maxima in exploitation, but their synchronization peaks in exploration.
PFC-DMN and hippocampus encode value maxima in exploitation, but their synchronization peaks in exploration.
Prefrontal default-mode network interactions with posterior hippocampus during exploration
Hippocampal maps and ventral prefrontal cortex (vPFC) value and goal representations support foraging in continuous spaces. How might hippocampal-vPFC interactions control the balance between behavior...
www.jneurosci.org
November 17, 2025 at 2:45 PM
@andrewpapale.bsky.social 's new explore/exploit paper in JNeurosci with @vanessabrown.bsky.social @drangelaianni.bsky.social Michael Hallquist & Bea Luna: www.jneurosci.org/content/earl...
PFC-DMN and hippocampus encode value maxima in exploitation, but their synchronization peaks in exploration.
PFC-DMN and hippocampus encode value maxima in exploitation, but their synchronization peaks in exploration.
Reposted by Andrew E. Papale
And now for something completely different!
In this new lab preprint led by Ceci Westbrook, we find a link between successful control of repetitive thought and increased activity in attention-related brain networks. By contrast, default mode activity was not associated with regulatory success.
In this new lab preprint led by Ceci Westbrook, we find a link between successful control of repetitive thought and increased activity in attention-related brain networks. By contrast, default mode activity was not associated with regulatory success.
Neural Correlates of Sustained Attention During Disengagement From Repetitive Thought: https://osf.io/8ea5z
August 1, 2025 at 12:33 AM
And now for something completely different!
In this new lab preprint led by Ceci Westbrook, we find a link between successful control of repetitive thought and increased activity in attention-related brain networks. By contrast, default mode activity was not associated with regulatory success.
In this new lab preprint led by Ceci Westbrook, we find a link between successful control of repetitive thought and increased activity in attention-related brain networks. By contrast, default mode activity was not associated with regulatory success.
Reposted by Andrew E. Papale
It's publication day for 📘Elusive Cures. What a moment! 1st book, 1st time on Mindscape (which, as many of you know, is one of my favorite podcasts).
Here, @seanmcarroll.bsky.social and I have a wide-ranging conversation around: Why are brain and mental disorders so hard to understand and treat?
Here, @seanmcarroll.bsky.social and I have a wide-ranging conversation around: Why are brain and mental disorders so hard to understand and treat?
Mindscape 317 | Nicole Rust @nicolecrust.bsky.social on Why Neuroscience Hasn't Solved Brain Disorders. Or, why Bench to Bedside is harder than it sounds. #MindscapePocast
www.preposterousuniverse.com/podcast/2025...
www.preposterousuniverse.com/podcast/2025...
June 10, 2025 at 11:33 AM
It's publication day for 📘Elusive Cures. What a moment! 1st book, 1st time on Mindscape (which, as many of you know, is one of my favorite podcasts).
Here, @seanmcarroll.bsky.social and I have a wide-ranging conversation around: Why are brain and mental disorders so hard to understand and treat?
Here, @seanmcarroll.bsky.social and I have a wide-ranging conversation around: Why are brain and mental disorders so hard to understand and treat?
Reading the "Networking" chapter about the internet in "Algorithms to Live By." Are healthy relationships in social psychology characterized by interactions that mirror TCP packets in Additive Increase, Multiplicative Decrease (AIMD) algorithms?
May 31, 2025 at 5:22 PM
Reading the "Networking" chapter about the internet in "Algorithms to Live By." Are healthy relationships in social psychology characterized by interactions that mirror TCP packets in Additive Increase, Multiplicative Decrease (AIMD) algorithms?
does nature, in the form of neural ensembles, prefer winner take all (first past the post) voting or ranked choice voting? Making an analogy to Democratic systems on this primary election day. Can a neuron represent multiple simultaneous and competing options?
May 20, 2025 at 1:06 PM
does nature, in the form of neural ensembles, prefer winner take all (first past the post) voting or ranked choice voting? Making an analogy to Democratic systems on this primary election day. Can a neuron represent multiple simultaneous and competing options?
Given the forces acting on a golf ball during a putt and the shape of the green, how many possible paths can it take to get to the hole? On any particular path, what is the margin of error on the magnitude and direction of the force applied by the club? ⛳️
April 12, 2025 at 1:10 AM
Given the forces acting on a golf ball during a putt and the shape of the green, how many possible paths can it take to get to the hole? On any particular path, what is the margin of error on the magnitude and direction of the force applied by the club? ⛳️
Reposted by Andrew E. Papale
Hey folks! I'll be teaching two workshops in May on Structural Equation Modeling!
One course is introductory (May 7-9): smart-workshops.com/intro-sem-info
The other is on longitudinal models (May 14-16): smart-workshops.com/long-sem-info
🙏Please RT and share! 🙏
Let met tell you more...
One course is introductory (May 7-9): smart-workshops.com/intro-sem-info
The other is on longitudinal models (May 14-16): smart-workshops.com/long-sem-info
🙏Please RT and share! 🙏
Let met tell you more...
Intro SEM Information — SMaRT Workshops
smart-workshops.com
April 7, 2025 at 11:01 AM
Hey folks! I'll be teaching two workshops in May on Structural Equation Modeling!
One course is introductory (May 7-9): smart-workshops.com/intro-sem-info
The other is on longitudinal models (May 14-16): smart-workshops.com/long-sem-info
🙏Please RT and share! 🙏
Let met tell you more...
One course is introductory (May 7-9): smart-workshops.com/intro-sem-info
The other is on longitudinal models (May 14-16): smart-workshops.com/long-sem-info
🙏Please RT and share! 🙏
Let met tell you more...
Reposted by Andrew E. Papale
We often use discretization to approximate continuous laws of physics, but it also goes the other way:
You can use continuous equations to approximate the behavior of discrete systems!
Here we'll see how electrical circuits can be modeled using the Laplace equation Δφ=0. [1/n]
You can use continuous equations to approximate the behavior of discrete systems!
Here we'll see how electrical circuits can be modeled using the Laplace equation Δφ=0. [1/n]
April 7, 2025 at 1:41 PM
We often use discretization to approximate continuous laws of physics, but it also goes the other way:
You can use continuous equations to approximate the behavior of discrete systems!
Here we'll see how electrical circuits can be modeled using the Laplace equation Δφ=0. [1/n]
You can use continuous equations to approximate the behavior of discrete systems!
Here we'll see how electrical circuits can be modeled using the Laplace equation Δφ=0. [1/n]
Has anyone applied big O notation to derive constraints on decision-making algorithms on the timescale of neural processing? 🤔
April 5, 2025 at 4:52 PM
Has anyone applied big O notation to derive constraints on decision-making algorithms on the timescale of neural processing? 🤔
Excited to share a summary of a new preprint looking at exploration in ventral prefrontal cortex and hippocampus using fMRI. A 🧵...1/15
April 3, 2025 at 12:11 AM
Excited to share a summary of a new preprint looking at exploration in ventral prefrontal cortex and hippocampus using fMRI. A 🧵...1/15
Reposted by Andrew E. Papale
Interested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b
Temporal fMRI Dynamics Map Dopamine Physiology
Spatial variations in dopamine function are linked to cognition and substance use disorders but are challenging to characterize with current methods. Because dopamine influences blood vessel dilation,...
www.biorxiv.org
March 26, 2025 at 12:40 PM
Interested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b
Reposted by Andrew E. Papale
Please share: FT RA opening in my lab w/ June/July start. Join a team studying cognitive risk for internalizing psychopathology during the transition to college. Good preparation for PhD (current RA is starting her PhD this fall, with me!) #PsychSciSky
brandeis.wd5.myworkdayjobs.com/Jobs/job/Bra...
brandeis.wd5.myworkdayjobs.com/Jobs/job/Bra...
Research Assistant - Psychology
Brandeis University is delighted to announce a job opportunity as a Research Assistant in the Snyder lab. The Research Assistant will assist the Principal Investigator in research projects involving c...
brandeis.wd5.myworkdayjobs.com
March 25, 2025 at 4:58 PM
Please share: FT RA opening in my lab w/ June/July start. Join a team studying cognitive risk for internalizing psychopathology during the transition to college. Good preparation for PhD (current RA is starting her PhD this fall, with me!) #PsychSciSky
brandeis.wd5.myworkdayjobs.com/Jobs/job/Bra...
brandeis.wd5.myworkdayjobs.com/Jobs/job/Bra...
Reposted by Andrew E. Papale
We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!
Mid-Career to Senior Principal Investigator
About OICR
OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...
oicr.bamboohr.com
February 4, 2025 at 4:05 PM
We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!
Reposted by Andrew E. Papale
Carl Olson, Professor of the Neuroscience Institute at CMU, died Nov. 23, 2024. Carl was a renowned neuroscientist who provided insights into fundamental issues in the neural basis of cognition. Read more about Carl's life and legacy in his published obituary. www.sciencedirect.com/science/arti...
March 20, 2025 at 1:03 PM
Carl Olson, Professor of the Neuroscience Institute at CMU, died Nov. 23, 2024. Carl was a renowned neuroscientist who provided insights into fundamental issues in the neural basis of cognition. Read more about Carl's life and legacy in his published obituary. www.sciencedirect.com/science/arti...
Reposted by Andrew E. Papale
My academic department (at Wesleyan University, CT, US) is searching for a one-year Visiting Professor position in Developmental Psychology. Great place to teach for a year! Apply here: wesleyan.wd5.myworkdayjobs.com/en-US/career...
Visiting Professor of Psychology
Visiting Professor in Developmental Psychology. The Department of Psychology at Wesleyan University invites applications for a one-year visiting professor in developmental psychology to begin Septembe...
wesleyan.wd5.myworkdayjobs.com
March 19, 2025 at 9:06 PM
My academic department (at Wesleyan University, CT, US) is searching for a one-year Visiting Professor position in Developmental Psychology. Great place to teach for a year! Apply here: wesleyan.wd5.myworkdayjobs.com/en-US/career...
Reposted by Andrew E. Papale
Dear trainee friends (et al.),
'Tis true that parts of the sky are falling & this is distracting. However, if you happen to have done A THING (paper, etc.), we want to support you. Don't hold back from letting us know. So we can learn and 👏.
We're still here for the science.
Sincerely,
Everyone
'Tis true that parts of the sky are falling & this is distracting. However, if you happen to have done A THING (paper, etc.), we want to support you. Don't hold back from letting us know. So we can learn and 👏.
We're still here for the science.
Sincerely,
Everyone
March 18, 2025 at 9:33 PM
Dear trainee friends (et al.),
'Tis true that parts of the sky are falling & this is distracting. However, if you happen to have done A THING (paper, etc.), we want to support you. Don't hold back from letting us know. So we can learn and 👏.
We're still here for the science.
Sincerely,
Everyone
'Tis true that parts of the sky are falling & this is distracting. However, if you happen to have done A THING (paper, etc.), we want to support you. Don't hold back from letting us know. So we can learn and 👏.
We're still here for the science.
Sincerely,
Everyone
Prefrontal default-mode network interactions with posterior hippocampus during exploration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Prefrontal default-mode network interactions with posterior hippocampus during exploration
Hippocampal maps and ventral prefrontal cortex (vPFC) value and goal representations support foraging in continuous spaces. How might hippocampal-vPFC interactions control the balance between behavior...
www.biorxiv.org
March 13, 2025 at 1:14 PM
Prefrontal default-mode network interactions with posterior hippocampus during exploration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrew E. Papale
Bluetorial: My NIH grant got funded; The money is in the bank
What happens behind the scenes with NIH fund transfers
What happens behind the scenes with NIH fund transfers
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
March 12, 2025 at 9:50 AM
Bluetorial: My NIH grant got funded; The money is in the bank
What happens behind the scenes with NIH fund transfers
What happens behind the scenes with NIH fund transfers
It might be fun 2 explore defining and categorizing simple shapes with the curvature method. Biologically, how do different joints and body compositions constrain curvature of movement trajectories? Could this lead to better control algorithms for robotics?
en.m.wikipedia.org/wiki/Curvature
en.m.wikipedia.org/wiki/Curvature
Curvature - Wikipedia
en.m.wikipedia.org
February 28, 2025 at 1:27 AM
It might be fun 2 explore defining and categorizing simple shapes with the curvature method. Biologically, how do different joints and body compositions constrain curvature of movement trajectories? Could this lead to better control algorithms for robotics?
en.m.wikipedia.org/wiki/Curvature
en.m.wikipedia.org/wiki/Curvature
Reposted by Andrew E. Papale
Confirmed (by many sources) news about 50 NIH Study Sections being allowed to announce meetings in the Federal Register.
As usual, MANY more questions than answers...
1/2
As usual, MANY more questions than answers...
1/2
a muppet news anchor says " and now a muppet news flash " while holding a piece of paper
ALT: a muppet news anchor says " and now a muppet news flash " while holding a piece of paper
media.tenor.com
February 26, 2025 at 7:57 PM
Confirmed (by many sources) news about 50 NIH Study Sections being allowed to announce meetings in the Federal Register.
As usual, MANY more questions than answers...
1/2
As usual, MANY more questions than answers...
1/2
Reposted by Andrew E. Papale
Unfortunately, this seems ever more relevant.
Thoughts today: What is the psychology of why we find destruction (e.g. demolition of a building, a car crash) exciting and worth watching? Is it different than the impulse to break things ourselves?
February 15, 2025 at 3:40 PM
Unfortunately, this seems ever more relevant.
Reposted by Andrew E. Papale
Get in dorks, we're going protesting!
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
February 10, 2025 at 11:57 PM
Get in dorks, we're going protesting!
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
Reposted by Andrew E. Papale
Tesla's stock is ridiculously overvalued, and even a modest consumer boycott could tank the company, which accounts for the majority of Elon Musk's wealth.
The divestment movement weakened apartheid South Africa. Let's do that again. slate.com/business/202...
The divestment movement weakened apartheid South Africa. Let's do that again. slate.com/business/202...
Don’t Buy a Tesla. Sell Your Tesla. Refuse a Tesla at the Rental Counter. Yes—It Will Help.
Elon Musk’s car company is in a precarious spot.
slate.com
February 12, 2025 at 1:42 PM
Tesla's stock is ridiculously overvalued, and even a modest consumer boycott could tank the company, which accounts for the majority of Elon Musk's wealth.
The divestment movement weakened apartheid South Africa. Let's do that again. slate.com/business/202...
The divestment movement weakened apartheid South Africa. Let's do that again. slate.com/business/202...
Reposted by Andrew E. Papale
I’ve been seething and grieving since yesterday’s Friday Night Massacre of NIH overheads, a seeming bit of bureaucratic trivial that will in fact destroy the US university system if unchecked. But I want to get away from budgets and rate breakdowns and F&A percentages for a moment.
Humor me?
Humor me?
February 8, 2025 at 9:41 PM
I’ve been seething and grieving since yesterday’s Friday Night Massacre of NIH overheads, a seeming bit of bureaucratic trivial that will in fact destroy the US university system if unchecked. But I want to get away from budgets and rate breakdowns and F&A percentages for a moment.
Humor me?
Humor me?