Anders Perner
@andersperner.bsky.social
Intensivist and prof. @Rigshospitalet, CPH, Denmark 🇩🇰
Collaboration for Research in Intensive Care www.cric.nu
Vicechair Danish Medical Societies
#6S #TRISS #CLASSIC #COVID_STEROID trials
#INCEPT Intensive Care Platform Trial www.incept.dk
Collaboration for Research in Intensive Care www.cric.nu
Vicechair Danish Medical Societies
#6S #TRISS #CLASSIC #COVID_STEROID trials
#INCEPT Intensive Care Platform Trial www.incept.dk
#INCEPT commenced it's second domain today
#INCEPT-thromboprophylaxis assesses the effect of low vs intermediate vs weight adjusted dose of LMWH in ICU
As a domain based platform trial #INCEPT enrols acutely admitted adult ICU pts
Presently in 4 🇩🇰 ICU soon in many and in 🇫🇮🇱🇺🇳🇴🇸🇪🇨🇭🇦🇽
www.incept.dk
#INCEPT-thromboprophylaxis assesses the effect of low vs intermediate vs weight adjusted dose of LMWH in ICU
As a domain based platform trial #INCEPT enrols acutely admitted adult ICU pts
Presently in 4 🇩🇰 ICU soon in many and in 🇫🇮🇱🇺🇳🇴🇸🇪🇨🇭🇦🇽
www.incept.dk
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients.
www.incept.dk
September 18, 2025 at 6:55 PM
#INCEPT commenced it's second domain today
#INCEPT-thromboprophylaxis assesses the effect of low vs intermediate vs weight adjusted dose of LMWH in ICU
As a domain based platform trial #INCEPT enrols acutely admitted adult ICU pts
Presently in 4 🇩🇰 ICU soon in many and in 🇫🇮🇱🇺🇳🇴🇸🇪🇨🇭🇦🇽
www.incept.dk
#INCEPT-thromboprophylaxis assesses the effect of low vs intermediate vs weight adjusted dose of LMWH in ICU
As a domain based platform trial #INCEPT enrols acutely admitted adult ICU pts
Presently in 4 🇩🇰 ICU soon in many and in 🇫🇮🇱🇺🇳🇴🇸🇪🇨🇭🇦🇽
www.incept.dk
INCEPT has recruited the first patient in the first domain - Albumin in shock
As a broad, inclusive domain-based platform trial for adult, acute ICU patients it will be embedded in clinical practice in 30+ hospitals in 🇩🇰 🇳🇴 🇸🇪 🇫🇮 🇮🇸 🇨🇭 🇳🇱
And markedly lower the barrier for improvements
www.incept.dk
As a broad, inclusive domain-based platform trial for adult, acute ICU patients it will be embedded in clinical practice in 30+ hospitals in 🇩🇰 🇳🇴 🇸🇪 🇫🇮 🇮🇸 🇨🇭 🇳🇱
And markedly lower the barrier for improvements
www.incept.dk
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients.
Www.incept.dk
June 30, 2025 at 10:00 AM
INCEPT has recruited the first patient in the first domain - Albumin in shock
As a broad, inclusive domain-based platform trial for adult, acute ICU patients it will be embedded in clinical practice in 30+ hospitals in 🇩🇰 🇳🇴 🇸🇪 🇫🇮 🇮🇸 🇨🇭 🇳🇱
And markedly lower the barrier for improvements
www.incept.dk
As a broad, inclusive domain-based platform trial for adult, acute ICU patients it will be embedded in clinical practice in 30+ hospitals in 🇩🇰 🇳🇴 🇸🇪 🇫🇮 🇮🇸 🇨🇭 🇳🇱
And markedly lower the barrier for improvements
www.incept.dk
High use of albumin in septic shock, maybe beneficial thru improved circulation,but harm in other pt groups
Perfect setup for a trial, so the albumin in shock domain will be the first on the Intensive Care Platform Trial starting next week www.incept.dk within the CRIC network www.cric.nu
Perfect setup for a trial, so the albumin in shock domain will be the first on the Intensive Care Platform Trial starting next week www.incept.dk within the CRIC network www.cric.nu
June 20, 2025 at 6:02 PM
High use of albumin in septic shock, maybe beneficial thru improved circulation,but harm in other pt groups
Perfect setup for a trial, so the albumin in shock domain will be the first on the Intensive Care Platform Trial starting next week www.incept.dk within the CRIC network www.cric.nu
Perfect setup for a trial, so the albumin in shock domain will be the first on the Intensive Care Platform Trial starting next week www.incept.dk within the CRIC network www.cric.nu
Improving and sustaining health is a global priority, yet most #HealthCare organizations do not systematically track the outcomes that matter most to patients, resulting in disparities in care, inefficient resource use, and an overburdened health workforce. Learn more: nej.md/4bxrKpb
#MedSky
#MedSky
April 15, 2025 at 10:53 AM
Reposted by Anders Perner
Improving and sustaining health is a global priority, yet most #HealthCare organizations do not systematically track the outcomes that matter most to patients, resulting in disparities in care, inefficient resource use, and an overburdened health workforce. Learn more: nej.md/4bxrKpb
#MedSky
#MedSky
April 14, 2025 at 1:17 PM
Improving and sustaining health is a global priority, yet most #HealthCare organizations do not systematically track the outcomes that matter most to patients, resulting in disparities in care, inefficient resource use, and an overburdened health workforce. Learn more: nej.md/4bxrKpb
#MedSky
#MedSky
Reposted by Anders Perner
The 5th Scandinavian intensivist meeting
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
SIM 2025 – Scandinavian Intensive Care Meeting 2025
scandinavianintensivistmeeting.nu
March 26, 2025 at 5:54 PM
The 5th Scandinavian intensivist meeting
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
The 5th Scandinavian intensivist meeting
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
SIM 2025 – Scandinavian Intensive Care Meeting 2025
scandinavianintensivistmeeting.nu
March 26, 2025 at 5:54 PM
The 5th Scandinavian intensivist meeting
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
14 – 16 May 2025
@Rigshospitalet - Copenhagen University Hospital
Register before 31 March
⚡ 200 Euro for full scientific & social program ⚡
Theme: Brain & gut - full program now available
scandinavianintensivistmeeting.nu
Interesting times ahead
Interested in adaptive platform trials?
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
March 22, 2025 at 7:00 AM
Interesting times ahead
And most ICUs likely use CRP 🫣
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.
ja.ma/3D8YB72
#MedSky
ja.ma/3D8YB72
#MedSky
February 25, 2025 at 9:19 PM
And most ICUs likely use CRP 🫣
Good news for ICUs and patients
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients.
incept.dk
February 23, 2025 at 12:34 PM
Good news for ICUs and patients
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
And it's from a platform trial in ALS 👌
🧵 CNM-Au8, an oral suspension of catalytically active gold particles, did not improve the primary efficacy outcome of amyotrophic lateral sclerosis disease progression.
ja.ma/3D6D4eZ
#MedSky
ja.ma/3D6D4eZ
#MedSky
February 17, 2025 at 8:40 PM
And it's from a platform trial in ALS 👌
A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
A Core Outcome Set for Adult General ICU Patients : Critical Care Medicine
nts exist, for example, respiratory failure, delirium, and COVID-19, but not for ICU patients in general. Accordingly, we aimed to develop a core outcome set for adult general ICU patients.
Design:
...
journals.lww.com
January 8, 2025 at 8:58 PM
A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Scandinavian Intensivist Meeting (SIM) will be in Copenhagen 14-16 May, 2025
The program is now released - the themes are brain, gut & academia
SIM 2025 will be a single-track, low-key meeting with interaction, networking, and a full social program.
scandinavianintensivistmeeting.nu
The program is now released - the themes are brain, gut & academia
SIM 2025 will be a single-track, low-key meeting with interaction, networking, and a full social program.
scandinavianintensivistmeeting.nu
SIM 2025 – Scandinavian Intensive Care Meeting 2025
scandinavianintensivistmeeting.nu
January 8, 2025 at 8:50 PM
Scandinavian Intensivist Meeting (SIM) will be in Copenhagen 14-16 May, 2025
The program is now released - the themes are brain, gut & academia
SIM 2025 will be a single-track, low-key meeting with interaction, networking, and a full social program.
scandinavianintensivistmeeting.nu
The program is now released - the themes are brain, gut & academia
SIM 2025 will be a single-track, low-key meeting with interaction, networking, and a full social program.
scandinavianintensivistmeeting.nu