Alessio Fragasso
@alessiofragasso.bsky.social
Postdoc fellow in Jacobs-Wagner lab at Stanford University, former PhD in Cees Dekker lab at TU Delft | quantitative biology, antimicrobial peptides, synthetic biology, biomimetics, nanopores
Pinned
Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities
Cationic antimicrobial peptides are a large family of host defense molecules with diverse sequences and structures. Here, we present a computational and experimental pipeline for quantifying the membr...
biorxiv.org
Excited to share our first big story from my postdoc @JacobsWagnerLab, now on biorxiv: biorxiv.org/content/10.1...
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩
Reposted by Alessio Fragasso
Thrilled to share our latest publication led by amazing Yashna Thappeta & @silviajcanasd.bsky.social + collab. w/ Cegelski lab. We show that glycogen phase separation leads to asymmetric division and cytoplasmic content rearrangement in E. coli exiting exponential phase due to nutrient depletion.
Glycogen phase-separation drives macromolecular rearrangement and asymmetric division in E. coli | The EMBO Journal
imageimageSubcellular organization of bacterial cells transitioning from exponential to stationary
phase has not been well investigated. This study shows that transition-phase E. coli cells exhibit as...
www.embopress.org
November 3, 2025 at 5:07 PM
Thrilled to share our latest publication led by amazing Yashna Thappeta & @silviajcanasd.bsky.social + collab. w/ Cegelski lab. We show that glycogen phase separation leads to asymmetric division and cytoplasmic content rearrangement in E. coli exiting exponential phase due to nutrient depletion.
Reposted by Alessio Fragasso
Hello! The Jacobs-Wagner lab is finally on Bluesky. We’re excited to celebrate science (and scientists!), share our research, and interact with the community. We look forward to connecting with friends and colleagues across the world.
October 19, 2025 at 8:06 PM
Hello! The Jacobs-Wagner lab is finally on Bluesky. We’re excited to celebrate science (and scientists!), share our research, and interact with the community. We look forward to connecting with friends and colleagues across the world.
Reposted by Alessio Fragasso
WORK!
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
August 13, 2025 at 1:30 PM
WORK!
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
What an amazing time at the EMBO Fellows Meeting! Honored to be part of such an inspiring community, had a lot of fun connecting with this group of incredible researchers and hear about their science. A big thank you to the #EMBO organizers! 🤩
119 EMBO Fellows from 30+ countries attended the EMBO Fellows’ Meeting in Heidelberg, DE from 27 June–1 July. #Research was shared and connections formed – an incredible opportunity for #networking and #collaboration. Thank you to all who joined and were part of this vibrant community! 🧪
July 4, 2025 at 11:25 AM
What an amazing time at the EMBO Fellows Meeting! Honored to be part of such an inspiring community, had a lot of fun connecting with this group of incredible researchers and hear about their science. A big thank you to the #EMBO organizers! 🤩
Reposted by Alessio Fragasso
The EMBO Fellows’ Meeting 2025 is taking place in Heidelberg, DE from 27 June–1 July. Over 100 EMBO Fellows from 30+ countries will present their projects, #network, receive #training and #mentoring, speak with EMBO Press editors and learn about new EMBO #policy and #sustainability initiatives. 🧪
June 30, 2025 at 4:23 PM
The EMBO Fellows’ Meeting 2025 is taking place in Heidelberg, DE from 27 June–1 July. Over 100 EMBO Fellows from 30+ countries will present their projects, #network, receive #training and #mentoring, speak with EMBO Press editors and learn about new EMBO #policy and #sustainability initiatives. 🧪
Reposted by Alessio Fragasso
I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
June 7, 2025 at 11:30 PM
I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
Reposted by Alessio Fragasso
Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social
www.nature.com/articles/s41...
rdcu.be/epIB7
www.nature.com/articles/s41...
rdcu.be/epIB7
June 6, 2025 at 7:06 PM
Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social
www.nature.com/articles/s41...
rdcu.be/epIB7
www.nature.com/articles/s41...
rdcu.be/epIB7
Reposted by Alessio Fragasso
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
May 19, 2025 at 1:23 PM
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
Reposted by Alessio Fragasso
Webinar TOMORROW at 16:00 CET/10:00 AM EDT regarding a breakthrough Nature paper from Prof. Yifat Merbl's group. Registration if FREE! Just sign up to become an iAMPNet member and register. Use the links below!
www.iampnet.com/become-a-mem...
events.teams.microsoft.com/event/57387b...
www.iampnet.com/become-a-mem...
events.teams.microsoft.com/event/57387b...
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
May 19, 2025 at 2:24 PM
Webinar TOMORROW at 16:00 CET/10:00 AM EDT regarding a breakthrough Nature paper from Prof. Yifat Merbl's group. Registration if FREE! Just sign up to become an iAMPNet member and register. Use the links below!
www.iampnet.com/become-a-mem...
events.teams.microsoft.com/event/57387b...
www.iampnet.com/become-a-mem...
events.teams.microsoft.com/event/57387b...
Reposted by Alessio Fragasso
“There is so much beauty in what we can learn through science, in how complicated life is, and in trying to understand how it works. It’s what motivates me to wake up every morning.”
Opinion | I Came to Study Aging. Now I’m Trapped in ICE Detention.
www.nytimes.com
May 13, 2025 at 3:16 PM
“There is so much beauty in what we can learn through science, in how complicated life is, and in trying to understand how it works. It’s what motivates me to wake up every morning.”
Reposted by Alessio Fragasso
Postdoc position available!
This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠
Please re-post 🙏
www.jobs.ac.uk/job/DMY885/r...
This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠
Please re-post 🙏
www.jobs.ac.uk/job/DMY885/r...
Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy at Newcastle University
Apply for the Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy role on jobs.ac.uk, the top job board for academic positions in higher education. View det...
www.jobs.ac.uk
May 6, 2025 at 12:43 PM
Postdoc position available!
This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠
Please re-post 🙏
www.jobs.ac.uk/job/DMY885/r...
This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠
Please re-post 🙏
www.jobs.ac.uk/job/DMY885/r...
Reposted by Alessio Fragasso
💻 Apply to our beginner-friendly Boston Bioimage Analysis Course!
Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required!
Fee waivers available thanks to funding from @bioimagingna.bsky.social!
🗓️ Apply June 1st!
iac.hms.harvard.edu/bobiac/2025/
Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required!
Fee waivers available thanks to funding from @bioimagingna.bsky.social!
🗓️ Apply June 1st!
iac.hms.harvard.edu/bobiac/2025/
May 8, 2025 at 2:39 PM
💻 Apply to our beginner-friendly Boston Bioimage Analysis Course!
Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required!
Fee waivers available thanks to funding from @bioimagingna.bsky.social!
🗓️ Apply June 1st!
iac.hms.harvard.edu/bobiac/2025/
Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required!
Fee waivers available thanks to funding from @bioimagingna.bsky.social!
🗓️ Apply June 1st!
iac.hms.harvard.edu/bobiac/2025/
Reposted by Alessio Fragasso
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
March 13, 2025 at 4:37 PM
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Reposted by Alessio Fragasso
Bacteria living in the human gut are found to evolve persistent resistance after brief exposure to antibiotics.
Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.
🧪🦠
www.nature.com/articles/d41...
Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.
🧪🦠
www.nature.com/articles/d41...
Tracking the evolution and persistence of antibiotic resistance in the human gut
A genomic study of gut microbes during antibiotic use finds selective sweeps in a DNA gyrase gene that drive resistance.
www.nature.com
April 26, 2025 at 7:43 AM
Bacteria living in the human gut are found to evolve persistent resistance after brief exposure to antibiotics.
Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.
🧪🦠
www.nature.com/articles/d41...
Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.
🧪🦠
www.nature.com/articles/d41...
Out now! @biorxivpreprint.bsky.social from my PhD at #CDlab
We design, experimentally test, and simulate a library of designer FG-nucleoporins.
We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.
Congrats to all co-authors! 🥳
We design, experimentally test, and simulate a library of designer FG-nucleoporins.
We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.
Congrats to all co-authors! 🥳
Latest #CDlab paper on @biorxivpreprint.bsky.social: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
April 25, 2025 at 5:01 PM
Out now! @biorxivpreprint.bsky.social from my PhD at #CDlab
We design, experimentally test, and simulate a library of designer FG-nucleoporins.
We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.
Congrats to all co-authors! 🥳
We design, experimentally test, and simulate a library of designer FG-nucleoporins.
We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.
Congrats to all co-authors! 🥳
Reposted by Alessio Fragasso
Now online! Tissue geometry spatiotemporally drives bacterial infections
Tissue geometry spatiotemporally drives bacterial infections
Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.
dlvr.it
April 21, 2025 at 6:51 PM
Now online! Tissue geometry spatiotemporally drives bacterial infections
Reposted by Alessio Fragasso
Does marrying a fellow scientist boost your career?
In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!
In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!
March 21, 2025 at 2:33 PM
Does marrying a fellow scientist boost your career?
In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!
In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!
Reposted by Alessio Fragasso
🦠 Most #bacteria form #biofilms, protective communities that resist #antibiotics.
Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies.
Read more 👉 buff.ly/YajqauG
@krastevalab.bsky.social @iecb.bsky.social @CNRS.fr
Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies.
Read more 👉 buff.ly/YajqauG
@krastevalab.bsky.social @iecb.bsky.social @CNRS.fr
Deciphering the formation of cooperative multicellular biofilms
Bacterial films are a hazard throughout the healthcare system, and as antibiotic resistance increases there is an even greater imperative...
buff.ly
April 20, 2025 at 11:30 AM
🦠 Most #bacteria form #biofilms, protective communities that resist #antibiotics.
Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies.
Read more 👉 buff.ly/YajqauG
@krastevalab.bsky.social @iecb.bsky.social @CNRS.fr
Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies.
Read more 👉 buff.ly/YajqauG
@krastevalab.bsky.social @iecb.bsky.social @CNRS.fr
Reposted by Alessio Fragasso
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
April 18, 2025 at 3:55 PM
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Excited to share our first big story from my postdoc @JacobsWagnerLab, now on biorxiv: biorxiv.org/content/10.1...
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩
Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities
Cationic antimicrobial peptides are a large family of host defense molecules with diverse sequences and structures. Here, we present a computational and experimental pipeline for quantifying the membr...
biorxiv.org
April 12, 2025 at 12:55 AM
Excited to share our first big story from my postdoc @JacobsWagnerLab, now on biorxiv: biorxiv.org/content/10.1...
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩
We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes
Huge thanks to Christine and coauthors! 🥳🤩