Bassem Hassan
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bassemh.bsky.social
Bassem Hassan
@bassemh.bsky.social

World citizen, Time and Variation in Brain Development, football, cheese, wine, single malt!

Biology 53%
Neuroscience 37%

It was areal pleasure to visit and exchange with colleagues about the beautiful science being done. Thank you for having me!
Today we had the pleasure of hosting Dr. Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social at our #SeminarsIN with his talk: “Temporal control of neurogenesis”
A fantastic lecture, thank you! 👏👏
@csic.es @dicv.csic.es @umh.es @borrell-lab.bsky.social

Reposted by Bassem A. Hassan

Today we had the pleasure of hosting Dr. Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social at our #SeminarsIN with his talk: “Temporal control of neurogenesis”
A fantastic lecture, thank you! 👏👏
@csic.es @dicv.csic.es @umh.es @borrell-lab.bsky.social

Thank you for the invitation. Really looking forward to the visit.
We have the pleasure of welcoming Dr Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social tomorrow at #SeminarsIN 🙌
He is a world leader in the study of genetic regulation of brain development.
Don’t miss it!
@borrell-lab.bsky.social @csic.es @dicv.csic.es @umh.es

Reposted by Bassem A. Hassan

We have the pleasure of welcoming Dr Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social tomorrow at #SeminarsIN 🙌
He is a world leader in the study of genetic regulation of brain development.
Don’t miss it!
@borrell-lab.bsky.social @csic.es @dicv.csic.es @umh.es

Julien Pigeon and colleagues show how conserved processes can be fine tuned to result in species-specific patterns of brain development. Thanks to @alexbaffet.bsky.social @boyanbonev.bsky.social @neurogenesis-i3s.bsky.social for a great collaboration
👇🏽

Reposted by Bassem A. Hassan

www.biorxiv.org/content/10.1...
Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis
Post-translational Tuning of Human Cortical Progenitor Neuronal Output
The striking expansion of the human neocortex is driven by the ability of radial glial cells (RGCs) to prolong neurogenesis without exhausting their progenitor pool, thereby producing more neurons, pa...
www.biorxiv.org

Looking forward to this exciting meeting

Reposted by Bassem A. Hassan

👇🏽

Reposted by Bassem A. Hassan

Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder. www.linkedin.com/posts/bassem...
Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders | Bassem Hassan
Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder.
www.linkedin.com

Reposted by Bassem A. Hassan

Reposted by Bassem A. Hassan

Registration is now open for 2026 GRC on Neural Development
@neuraldevgrc.bsky.social
Register early because places go fast!

Reposted by Bassem A. Hassan

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...
Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications
This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...
www.nature.com

Reposted by Bassem A. Hassan

“How does a brain take shape?” Neurobiologist @bassemh.bsky.social on the embryonic cells that fold into the neural tube and become the brain.
Discover more in The Brain’s Secret.

#Biology #Neuroscience #Brain #Education #ReliableKnowledge #PublicEngagement

One can only hope that history will judge harshly all those who are complicit in or remain silent in the face of genocide
aje.io/uj36z1
I may starve to death before I am able to graduate in Gaza
My only dream is to take the tawjihi exam so I can continue my education. Is this too much to ask?
aje.io

Reposted by Bassem A. Hassan

Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social!
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠

Reposted by Bassem A. Hassan

There is only one name for that: this is a crime against humanity. Israel is governed by monsters.
Israel is destroying the subsistence of Gaza's population, from agriculture to fishing
More than 95% of farmland has been damaged or lies in areas inaccessible to farmers, as the Palestinian enclave suffers from famine.
www.lemonde.fr

Reposted by Bassem A. Hassan

"Solo le pido a Dios
Que la guerra no me sea indiferente
Es un monstruo grande y pisa fuerte
Toda la pobre inocencia de la gente"

www.youtube.com/watch?v=Gvyl...
Mercedes Sosa - Sólo Le Pido a Dios (con León Gieco)
YouTube video by Rio Grande Records
www.youtube.com

Intriguing! If true, this would be further evidence in support of the concept of developmental origins of neurodegenerative disorders pubmed.ncbi.nlm.nih.gov/37184296/
The brain on time: links between development and neurodegeneration - PubMed
Neurodegenerative diseases are characterized by the progressive loss of structure or function of neurons. In this Spotlight, we explore the idea that genetic forms of neurodegenerative disorders might...
pubmed.ncbi.nlm.nih.gov

This was a really exciting and fun conference organized in a lovely setting. It was a pleasure to be part of it. Thanks for having me and congratulations to the organizers for putting it together. I hope it’s the first of many!

Reposted by Bassem A. Hassan

Bassem Hassan @bassemh.bsky.social discussing Temporal control of Neurogenesis at #neurogen25 . What governs the length? How do novel genetic elements interact with highly conserved mechanisms?

@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social

Very much looking forward to the next 3 days of frontier neurobiology!

Just drop me an email bassem.hassan@icm-institute.org if you want the full text PDF

While I applaud Europe taking a step to fund bringing scientific excellence to Europe, the ERC’s current success rates at 10% for Europe based scientists is statistically at lottery levels. The total ERC budget should double across the board aiming at doubling funding rates.

Reposted by Bassem A. Hassan

Fantastic opportunity for neuroscience research.
The ROGER DE SPOELBERCH Prize for a basic or clinical research project in the areas of neurodegenerative diseases or psychiatric disorders.
750.000 EUR - Deadline JUNE 30 2025.
www.fondation-roger-de-spoelberch.ch/en/roger-de-...
ROGER DE SPOELBERCH Prize | Fondation ROGER DE SPOELBERCH
Each year, the Foundation awards the ROGER DE SPOELBERCH Prize to a laureate for a clinical or fundamental scientific research project in the field of neurodegenerative diseases and certain psychiatri...
www.fondation-roger-de-spoelberch.ch

Thank you for accepting the invitation to speak and I’m very glad you enjoyed the meeting

Reposted by Bassem A. Hassan

New from the lab: @maheandria.bsky.social and colleagues in collaboration with the Hiesinger, Stoeckli and von Kleist labs dissect the sequential emergence of axonal targeting during development in today's issue of Nature Neuroscience:
rdcu.be/ek010
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...
rdcu.be

Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...
rdcu.be

Reposted by Bassem A. Hassan

@maheandria.bsky.social and I challenge the notion of a static and deterministic definition of a (neural) cell type and argue for its replacement by a multi parametric probabilistic definition in this perspective
sciencedirect.com/science/arti...
Toward a probabilistic definition of neural cell types
A classical view of cell type relies on a definite set of stable properties that are critical for brain functions. Single-cell technologies led to an …
sciencedirect.com