#preLight⬇️
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prelights.bsky.social
The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.

Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social

Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...
Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation - preLights
The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.
prelights.biologists.com
January 28, 2026 at 3:36 PM
prelights.bsky.social
The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩

Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint

#preLight ⬇️
prelights.biologists.com/highlights/a...
Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton - preLights
The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin.
prelights.biologists.com
January 27, 2026 at 11:31 AM
prelights.bsky.social
preLighter Stefan Friedrich Wirth covers a #preprint from Dr Raychoudhury & team #DBS_IISERM

It concludes that the isolation mechanisms preventing mating between different species of parasitoid Nasonia wasps remain a mystery 🔮 #zoology #evolution

#preLight⬇️
prelights.biologists.com/highlights/m...
Morphological variations in external genitalia do not explain the interspecific reproductive isolation in Nasonia species complex (Hymenoptera: Pteromalidae) - preLights
Isolation mechanisms that prevent mating between different species of parasitoid Nasonia wasps remain a mystery
prelights.biologists.com
January 26, 2026 at 12:47 PM
prelights.bsky.social
Kanishka Parashar #UNIL has uploaded a #postLight. 👀

Here, Kanishka revisits work from @matteoall.bsky.social & team originally posted as a #preprint, highlighted as a #preLight and now published in @jcellsci.bsky.social

#postLight ⬇️👀
prelights.biologists.com/highlights/p...
Image shows preLights post highlighting a preprint titled 'Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling'. In a dark-grey box below the title and preprint information you see a summary written by Kanishka Parashar: 'Paclitaxel destabilizes nuclear integrity in interphase by driving microtubule–vimentin aggregates towards the nucleus, leading to SUN2 dependent loss of Lamin A/C loss and enhanced cancer cell vulnerability even in slow proliferating tumors.'. In a blue box below, you see the postLight Kanishka recently added comparing the preprint with the published paper now published in Journal of Cell Science.
January 22, 2026 at 11:39 AM
prelights.bsky.social
Immune cells for nephron development; tweaking the organoid recipe!

Theodora mixes science writing & visuals to highlight recent work from Filipa Lopes, Susan Kimber & team #FBMH_UoM #preprint #DevBio

Check out the #preLight + author response ⬇️👀
prelights.biologists.com/highlights/h...
Human pluripotent stem cell-derived macrophages modify development of human kidney organoids - preLights
Immune cells for nephron development; tweaking the organoid recipe! In the preprint highlighted here, the authors use human PSC-derived organoids to evaluate the contribution of macrophages to kidney ...
prelights.biologists.com
January 21, 2026 at 10:28 AM
prelights.bsky.social
"I would risk over-heating just to be with you" - Male red-sided garter snake🔥🐍

Tshepiso Majelantle highlights recent work on thermoregulatory behaviour. #preprint #zoology

Includes an insightful response from @drhubert.bsky.social #OregonState

#preLight ⬇️
prelights.biologists.com/highlights/t...
Trade-offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress - preLights
"I would risk over-heating just to be with you" - Male red-sided garter snake
prelights.biologists.com
January 20, 2026 at 1:40 PM
prelights.bsky.social
KANK2 plays a dual role – dictating cells when to move and when to stick!

@vibhasingh.bsky.social covers recent work from Nikolina Stojanović & colleagues – includes a lovely discussion with the author team.

#preLight ⬇️
prelights.biologists.com/highlights/k...
KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism - preLights
KANK2 plays a dual role – dictating cells when to move and when to stick!
prelights.biologists.com
January 12, 2026 at 4:28 PM
prelights.bsky.social
Unconventional mechanisms of antibiotic action: Stacking and disorganizing. #biochemistry

Leonie Brüne talks to William Stuart & Nicholas J. Harmer #UoEBiosciences about their recent #preprint

Check out the #preLight + insightful discussion ⬇️
prelights.biologists.com/highlights/c...
Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline - preLights
Unconventional mechanisms of antibiotic action: Stacking and disorganizing
prelights.biologists.com
January 7, 2026 at 1:37 PM
prelights.bsky.social
From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.

Bhaval Parmar discusses recent work from Anubhav Prakash @prakash-patterns.bsky.social & colleagues. #DevBio

#preLight ⬇️
prelights.biologists.com/highlights/j...
Junctional Heterogeneity Shapes Epithelial Morphospace - preLights
From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.
prelights.biologists.com
January 5, 2026 at 2:40 PM
prelights.bsky.social
And one that covers a #preprint from the group of Peter Devreotes on plasma membrane symmetry breaking.

#preLight ⬇️
prelights.biologists.com/highlights/p...
PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration - preLights
One circuit to break them all: mutual inhibition of Ras–PIP5K circuit sparks polarity and migration.
prelights.biologists.com
December 31, 2025 at 2:26 PM
prelights.bsky.social
Two more recent preLights were written by Vibha Singh @vibhasingh.bsky.social 🙌

One that discusses Taxane-induced conformational changes in the microtubule lattice. #preprint from Joyce Meiring @joycemeiri.bsky.social and colleagues #UniUtrecht.

#preLight ⬇️
prelights.biologists.com/highlights/t...
Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling - preLights
More than just a stabilizer: Taxanes (cancer drugs) trigger the GEF-H1 – RhoA axis.
prelights.biologists.com
December 31, 2025 at 2:24 PM
prelights.bsky.social
Some excellent preLights to end 2025 🎆

The latest was written by Zhang-He Goh @goh-zhanghe.bsky.social, discussing an enzymatic method for tryptophan-specific bromination described in a recent #preprint from the lab of @amyweeks.bsky.social.

#preLight ⬇️
prelights.biologists.com/highlights/e...
Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling - preLights
Ready, set, brominate: RebH and engineered variant for bromination of peptidyl-Trp residues
prelights.biologists.com
December 31, 2025 at 2:14 PM
prelights.bsky.social
Check out the latest #preLight from the #preprint review initiative led by Marcus Oliveira #UFRJ #Brazil

⚡Characterising wavelength-selective regulation of keratinocyte metabolism from @aliciakowaltowski.bsky.social & team.

#preLight by Rickson Ribeiro ⬇️👀

prelights.biologists.com/highlights/m...
Mitochondrial Fatty Acid Oxidation is Stimulated by Red Light Irradiation - preLights
Different wavelengths of sunlight can modulate the viability of keratinocytes (Skin cells), and the metabolism. Red light, particularly, affects oxygen consumption during three days post-irradiation a...
prelights.biologists.com
December 19, 2025 at 11:38 AM
prelights.bsky.social
The failing heart hides a biochemical vulnerability ❤️‍🩹

Jeny Jose: By linking MGST1 loss to fibroblast activation, ROS accumulation, & ferroptosis susceptibility, this #preprint provides a new perspective on heart failure progression.

#preLight ⬇️
prelights.biologists.com/highlights/l...
Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure - preLights
The failing heart hides a biochemical vulnerability. MGST1, an antioxidant, down in fibroblasts means a ferroptosis-prone, oxidation-sensitive state. A new therapeutic angle surfaces.
prelights.biologists.com
December 17, 2025 at 8:44 AM
prelights.bsky.social
WHOLISTIC: A whole-body functional atlas of cellular dynamics

@sinanmalik.bsky.social covers work from the @mishaahrens.bsky.social Lab.

“This #preprint represents the kind of transformative science that redefines what is possible in a field.”

#preLight ⬇️
prelights.biologists.com/highlights/i...
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits - preLights
WHOLISTIC: A whole-body functional atlas of cellular dynamics
prelights.biologists.com
December 16, 2025 at 1:59 PM
prelights.bsky.social
Fibre for the win: Dietary influences on the gut microbiota 🦠

Jasmine Talevi covers recent work from Blake Dirks & colleagues describing the microbial functional response to two very different diets. #preprint #microbiome

#preLight ⬇️ 👀
prelights.biologists.com/highlights/m...
Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function - preLights
Fibre for the win: Dietary influences on the gut microbiota
prelights.biologists.com
December 16, 2025 at 11:53 AM
prelights.bsky.social
Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism. #preprint from @marthafield.bsky.social & team

#preLight by Yan Aveiro dos Reis ⬇️👀
prelights.biologists.com/highlights/v...
Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice - preLights
Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism.
prelights.biologists.com
December 10, 2025 at 12:14 PM
prelights.bsky.social
Meet TFlex— a new tool to uncover how natural & synthetic transcription factors shape human CD8+ T cell states. #Immunology

Inês Caiado highlights recent work from Riley Mullins & colleagues. #preprint

#preLight ⬇️ 👀
prelights.biologists.com/highlights/s...
Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states - preLights
Meet TFlex— a new tool to uncover how natural and synthetic transcription factors shape human CD8+ T cell states.
prelights.biologists.com
December 10, 2025 at 9:43 AM
prelights.bsky.social
A cardiomyocyte's journey to maturity ❤️

The #preprint authors, Mengmeng Huang & team #BurnsLab, generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.

A more visual #preLight by Theodora Stougiannou ⬇️ 👀
prelights.biologists.com/highlights/d...
Dosage-sensitive RBFOX2 autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome - preLights
A cardiomyocyte's journey to maturity: In the preprint highlighted here, the authors generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.
prelights.biologists.com
December 9, 2025 at 1:45 PM
prelights.bsky.social
Ancient Denisovan DNA from a 200,000-year-old genome + a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversity and local adaptation today.

#preLight by Siddharth Singh ⬇️ prelights.biologists.com/highlights/a...
A high-coverage genome from a 200,000-year-old Denisovan; A global map for introgressed structural variation and selection in humans - preLights
Ancient Denisovan DNA from a 200,000-year-old genome and a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversit...
prelights.biologists.com
December 8, 2025 at 1:20 PM
prelights.bsky.social
ILC2 orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines #immunology

André Luiz Amorim Costa discusses preprinted work from Rita Berkachy & colleagues now published in PLOS Pathogens. #postLight

#preLight⬇️
prelights.biologists.com/highlights/c...
Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells - preLights
ILC2—traditionally recognized for mediating anti-parasite responses—orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines
prelights.biologists.com
December 4, 2025 at 11:26 AM
prelights.bsky.social
On post-translational modifications & their contribution to help shape human cortical development 🧠

Jawdat Sandakly covers a recent #preprint from Julien Pigeon and colleagues @hassanbraindevlab.bsky.social. #DevBio #Neuroscience

Read the #preLight ⬇️👀
prelights.biologists.com/highlights/p...
Post-translational Tuning of Human Cortical Progenitor Neuronal Output - preLights
On post-translational modifications and their contribution to help shape human cortical development
prelights.biologists.com
December 3, 2025 at 11:18 AM
prelights.bsky.social
When gut microbes and CD4+ T cells go from chill to allergic drama queens 💥

Mitchell Sarmie teamed up with Serena Restori to highlight recent work from Alexa Weingarden & colleagues. #preprint #immunology

Check out the #preLight ⬇️
prelights.biologists.com/highlights/g...
Gut microbial composition modulates food-specific CD4+ T cells in food allergy - preLights
When gut microbes and CD4+ T cells go from chill to allergic drama queens
prelights.biologists.com
December 2, 2025 at 2:30 PM
prelights.bsky.social
GV101 will, GV101 will ROCK you!

Collaborative #preprint from David Herrmann & team
@garvaninstitute.bsky.social describes the impact of a ROCK2-specific inhibitor on both stromal & epithelial cells in the context of triple-negative breast cancer.
#preLight by Sharvari Pitke ⬇️
ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion - preLights
GV101 will, GV101 will ROCK you!
prelights.biologists.com
November 28, 2025 at 2:43 PM
prelights.bsky.social
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis🩸

Hannah Pletcher covers work from Narges Pourmandi &colleagues @lyssiotislab.bsky.social
#preLight⬇️
prelights.biologists.com/highlights/a...
Aspartate transaminases are required for blood development - preLights
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.
prelights.biologists.com
November 27, 2025 at 3:04 PM