#obinituzumab
🎙️ Just published a new episode of Blood Podcast: New Research: Mitochondrial DNA in TRALI and Venetoclax-Obinituzumab in CLL Trials. Have a listen:
New Research: Mitochondrial DNA in TRALI and Venetoclax-Obinituzumab in CLL Trials
In this week's episode, associate editor Dr. James Griffin interviews...
bloodpodcast.transistor.fm
November 13, 2025 at 5:00 PM
Great talk by our very own Dr. Brad Rovin @OhioStateNeph on LN therapies! Yes to Obinituzumab vis REGENCY. Belimumab works but may not all the way. And maybe CAR-T is the future!! Also keep HCQ going 🙏🏽
April 11, 2025 at 3:37 PM
Obinituzumab in NL in NEJM 2025.
But… complete renal response 30.9% in the placebo group?

www.nejm.org/doi/full/10....
Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis | NEJM
Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving stan...
www.nejm.org
February 8, 2025 at 6:31 PM
Difference btwn obinituzumab and rituxan is dosing schedule. 2 doses of obinituzumab at time 0, 6 mo, 12 mo is double 6 and 12 mo dose of rituxan.

Believe obinituzumab has better depletion than rituxan, but wonder how much of it is dose effect.

Why not give more rituxan? Its generic.
February 7, 2025 at 2:15 PM
But with so many options

What do you do beyond MMF/Prednisone in lupus nephritis?

- voclosporin (or other CNI)
- belimumab
- obinituzumab

No head:head trials

#ISNWCN #NephSky #RheumSky
February 7, 2025 at 12:16 PM
🧵 below
@nejm.org paper here: www.nejm.org/doi/full/10....

#ISNWCN LBCT of #obinituzumab in lupus nephritis
#SLE
February 7, 2025 at 12:06 PM
Obinituzumab does have more SAEs with the profound B cell depletion

Vaccination important !

#ISNWCN
February 7, 2025 at 9:34 AM
Next up is Brad Rovin on the REGENCY trial of obinituzumab in lupus nephritis

Background - more potent B cell depletion than Rituximab

Humanized
Less reliance on complement mediated
#ISNWCN #NephSky
February 7, 2025 at 9:32 AM