#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize…
www.sciencedirect.com
October 19, 2025 at 3:03 PM
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!