Structural analysis of apo and UDP-bound tetrahydrobiopterin glucosyltransferase revealed features at the active-site pocket differing from other retaining GT-B glycosyltransferases #Tetrahydrobiopterin #GTBGlycosyltransferase #Crystallography doi.org/10.1107/S205...

Structural analysis of the tetrahydrobiopterin glucosyltransferase PsBGluT from Pseudanabaena sp. Chao 1811 doi.org/10.1107/S205...

Zang, Jiang and Zhou: Structural analysis of the tetrahydrobiopterin glucosyltransferase PsBGluT from Pseudanabaena sp. Chao 1811 ##Tetrahydrobiopterin##GTBGlycosyltransferase##Crystallography... ##IUCrhttps://journals.iucr.org/paper?S2053230X25009446

🧬Science Wednesdays

A signaling pathway is a series of events on and within a cell that conveys information and leads to a specific function or response.

Learn more about signaling pathways and a study investigating the tetrahydrobiopterin (BH4) pathway: ow.ly/2i6A50XbPsq

#pwME #pwLC #BH4

it's autosomal dominant with reduced penetrance, which means that not everyone with the gene is symptomatic, but everyone who has it has a break in the pipeline which makes dopamine, often around the tetrahydrobiopterin cofactor.

You are listening. You are learning about QDPR autosomal recessive tetrahydrobiopterin-deficient hyperphenylalaninemia due to quinoid dihydropteridine reductase deficiency

I didn't know you were a carrier for quinoid dihydropteridine reductase autosomal recessive tetrahydrobiopterin-deficient hyperhenylalaninemia due to quinoid dihydropteridine reductase deficiency. What's that like

Sry to hear about a QDPR autosomal recessive tetrahydrobiopterin-deficient hyperphenylalaninemia due to quinoid dihydropteridine reductase deficiency, all my homies hate QDPR autosomal recessive tetrahydrobiopterin-deficient hyperphenylalaninemia due to quinoid dihydropteridine reductase deficiency

Tetrahydrobiopterin (BH4) is an essential cofactor for HYDROXYLASE enzymes involved in the metabolism of:
-Phenylalanine
-Tyrosine
-Tryptophan

Impaired BH4 → Hyperphenylalaninemia & ↓levels of neurotransmitters (dopamine, serotonin), causing progressive neurologic findings

Neue Publikation:
L-Citrullin und Tetrahydrobiopterin als Ernährungsintervention bei peripherer arterieller Verschlusskrankheit: Eine randomisierte Phase-II-Studie (CIPER-Studie)

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Brazilian Study Finds That Tetrahydrobiopterin is a Promising Therapeutic for Autism Spectrum Disorder

www.thailandmedical.news/news/brazili...

University of Wisconsin Study Uncovers Role of Tetrahydrobiopterin in Chronic Fatigue Syndrome

www.thailandmedical.news/news/univers...

Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? www.mdpi.com/2218-273X/15... #BH4 #MEcfs #pwME

Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? — Rahman et al.

www.s4me.info/threads/tetr...

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Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe?

[OI = orthostatic intolerance]

www.mdpi.com/2218-273X/15...

Image is from the Science for ME latest update

#MEcfs #CFS #PwME