New US research:

Dysregulation of tetrahydrobiopterin metabolism in #MyalgicEncephalomyelitis / #ChronicFatigueSyndrome by pentose phosphate pathway

Free fulltext:
journals.sagepub.com/doi/10.1177/...

#MEcfs #CFS #PwME

Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe?

[OI = orthostatic intolerance]

www.mdpi.com/2218-273X/15...

Image is from the Science for ME latest update

#MEcfs #CFS #PwME

Structural analysis of apo and UDP-bound tetrahydrobiopterin glucosyltransferase revealed features at the active-site pocket differing from other retaining GT-B glycosyltransferases #Tetrahydrobiopterin #GTBGlycosyltransferase #Crystallography doi.org/10.1107/S205...

Neue Publikation:
L-Citrullin und Tetrahydrobiopterin als Ernährungsintervention bei peripherer arterieller Verschlusskrankheit: Eine randomisierte Phase-II-Studie (CIPER-Studie)

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it's autosomal dominant with reduced penetrance, which means that not everyone with the gene is symptomatic, but everyone who has it has a break in the pipeline which makes dopamine, often around the tetrahydrobiopterin cofactor.

You are listening. You are learning about QDPR autosomal recessive tetrahydrobiopterin-deficient hyperphenylalaninemia due to quinoid dihydropteridine reductase deficiency

Tetrahydrobiopterin—A Cause of Orthostatic Imbalance in People with ME/CFS (2024)

"traced the origin of low blood pressure and orthostatic imbalance in patients with ME/CFS by dissecting the metabolic pathway responsible for making tetrahydrobiopterin—the pentose phosphate pathway"
#MECFS
#NEISvoid

Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? www.mdpi.com/2218-273X/15... #BH4 #MEcfs #pwME

I didn't know you were a carrier for quinoid dihydropteridine reductase autosomal recessive tetrahydrobiopterin-deficient hyperhenylalaninemia due to quinoid dihydropteridine reductase deficiency. What's that like

🧬Science Wednesdays

A signaling pathway is a series of events on and within a cell that conveys information and leads to a specific function or response.

Learn more about signaling pathways and a study investigating the tetrahydrobiopterin (BH4) pathway: ow.ly/2i6A50XbPsq

#pwME #pwLC #BH4

Zang, Jiang and Zhou: Structural analysis of the tetrahydrobiopterin glucosyltransferase PsBGluT from Pseudanabaena sp. Chao 1811 ##Tetrahydrobiopterin##GTBGlycosyltransferase##Crystallography... ##IUCrhttps://journals.iucr.org/paper?S2053230X25009446

Plain Language Summary
Tetrahydrobiopterin (BH4) metabolism is tightly regulated in a healthy individual. Recently, our research showed that BH4 level is upregulated in the plasma samples of ME/CFS patients with orthostatic intolerance. While investigating the molecular mechanism, our current study

Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway: journals.sagepub.com/doi/full/10....

Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? — Rahman et al.

www.s4me.info/threads/tetr...

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I'm doing my best to interpret the Wikipedia page on hyperphenylalaninemia & tetrahydrobiopterin but I'm not an expert in biochem.

...

"The typical cost of treating a patient with Kuvan [tetrahydrobiopterin replacement] is US$100,000 per year." Jesus H. Christ. For-profit pharma is cancer. [3/4]