#PluripotentCells
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plosbiology.org
How do #PluripotentCells acquire lineage-specific identities during #GermLayer specification? This study shows that maternal TFs Foxi2 & Sox3 act as master regulators of ectodermal germ layer specification, ensuring robust & precise expression of target genes @plosbiology.org 🧪 plos.io/4nIUu2O
Top left: Phenotypic analysis of Foxi2, Sox3, and Foxi2/Sox3 morphants at the early tailbud stage. Top right: Single nucleus RNA-seq UMAP (uniform manifold approximation projection) identifying 14 distinct cell types in the early gastrula. Bottom: Schematic diagram depicting the regulatory roles of Foxi2 and Sox3, either independently or jointly, in activating the expression of target genes across various ectodermal cell types.
November 7, 2025 at 1:55 PM
plosbiology.org
How do #PluripotentCells acquire lineage-specific identities during #GermLayer specification? This study shows that maternal TFs Foxi2 & Sox3 act as master regulators of ectodermal germ layer specification, ensuring robust & precise expression of target genes @plosbiology.org 🧪 plos.io/4nIUu2O
Top left: Phenotypic analysis of Foxi2, Sox3, and Foxi2/Sox3 morphants at the early tailbud stage. Top right: Single nucleus RNA-seq UMAP (uniform manifold approximation projection) identifying 14 distinct cell types in the early gastrula. Bottom: Schematic diagram depicting the regulatory roles of Foxi2 and Sox3, either independently or jointly, in activating the expression of target genes across various ectodermal cell types.
November 6, 2025 at 5:26 PM
plosbiology.org
How do #PluripotentCells acquire lineage-specific identities during #GermLayer specification? This study shows that maternal TFs Foxi2 & Sox3 act as master regulators of ectodermal germ layer specification, ensuring robust & precise expression of target genes @plosbiology.org 🧪 plos.io/4nIUu2O
Top left: Phenotypic analysis of Foxi2, Sox3, and Foxi2/Sox3 morphants at the early tailbud stage. Top right: Single nucleus RNA-seq UMAP (uniform manifold approximation projection) identifying 14 distinct cell types in the early gastrula. Bottom: Schematic diagram depicting the regulatory roles of Foxi2 and Sox3, either independently or jointly, in activating the expression of target genes across various ectodermal cell types.
November 7, 2025 at 9:02 AM