We’re pleased to welcome Dimitri Krainc, MD, PhD (USA) to the 7th World Parkinson Congress, where he’ll present on a parallel session on PD Research Advances in GBA1- and LRRK2-Associated Parkinson’s Disease.
🔗 https://wpc2026.org/ScientificProgram
#wpc2026 #Parkinsons
🔗 https://wpc2026.org/ScientificProgram
#wpc2026 #Parkinsons
January 18, 2026 at 3:29 PM
We’re pleased to welcome Dimitri Krainc, MD, PhD (USA) to the 7th World Parkinson Congress, where he’ll present on a parallel session on PD Research Advances in GBA1- and LRRK2-Associated Parkinson’s Disease.
🔗 https://wpc2026.org/ScientificProgram
#wpc2026 #Parkinsons
🔗 https://wpc2026.org/ScientificProgram
#wpc2026 #Parkinsons
New review: "Higher consumption of total dairy and plain milk is associated with an increased risk of developing Parkinson's disease" #parkinsons #milk #dairy #neurology #neurosky #medsky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Association between dairy consumption and Parkinson's disease: A systematic review and meta-analysis
Parkinson's disease (PD) is a progressive neurodegenerative disorder with no cure and rising global prevalence. Genetic, environmental, and dietary fa…
www.sciencedirect.com
January 17, 2026 at 3:32 AM
New review: "Higher consumption of total dairy and plain milk is associated with an increased risk of developing Parkinson's disease" #parkinsons #milk #dairy #neurology #neurosky #medsky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Like something out of a horror movie :)
"Zombosomes" shed from astrocytes, but retain their adhesive & motile properties (even though they lack nuclei), acting as disease couriers, transferring #Parkinsons -associated α-synuclein aggregates between cells
www.cell.com/cell-reports...
"Zombosomes" shed from astrocytes, but retain their adhesive & motile properties (even though they lack nuclei), acting as disease couriers, transferring #Parkinsons -associated α-synuclein aggregates between cells
www.cell.com/cell-reports...
January 16, 2026 at 11:51 AM
Like something out of a horror movie :)
"Zombosomes" shed from astrocytes, but retain their adhesive & motile properties (even though they lack nuclei), acting as disease couriers, transferring #Parkinsons -associated α-synuclein aggregates between cells
www.cell.com/cell-reports...
"Zombosomes" shed from astrocytes, but retain their adhesive & motile properties (even though they lack nuclei), acting as disease couriers, transferring #Parkinsons -associated α-synuclein aggregates between cells
www.cell.com/cell-reports...
A new study co-authored by #SOTMembers found that long-term residential exposure to the pesticide chlorpyrifos may be associated with a higher risk of developing #Parkinsons disease: www.uclahealth.org/news/release...
Widely used pesticide linked to more than doubled Parkinson’s risk
A new study from UCLA Health has found that long-term residential exposure to the pesticide chlorpyrifos is associated with more than a 2.5-fold increased risk of developing Parkinson's disease. The research, published in the journal Molecular Neurodegeneration, combines human population data with laboratory experiments showing how the pesticide damages dopamine-producing brain cells, providing biological evidence for the link.
www.uclahealth.org
January 15, 2026 at 8:07 PM
A new study co-authored by #SOTMembers found that long-term residential exposure to the pesticide chlorpyrifos may be associated with a higher risk of developing #Parkinsons disease: www.uclahealth.org/news/release...
Treating #SleepApnea with a continuous positive airway pressure (or CPAP) machine was associated with a reduced likelihood of developing #Parkinsons. https://azpbs.org/horizon/2025/12/sleep-apnea-parkinsons-disease-risk/
New study links sleep apnea to higher risk of Parkinson's disease
A new study shows a link between sleep apnea and a higher risk of Parkinson's disease, highlighting the importance of early diagnosis & more.
azpbs.org
January 12, 2026 at 2:41 AM
Treating #SleepApnea with a continuous positive airway pressure (or CPAP) machine was associated with a reduced likelihood of developing #Parkinsons. https://azpbs.org/horizon/2025/12/sleep-apnea-parkinsons-disease-risk/
iu"health" bought our hospitals- iu gets federal grants 2 study pcb associated disorders they all claim don't exist-partly in their big neurology school.because parkinsons, alzheimer's-etc-are prevalent here with cancers including "rare" ones.atsdr declared deadly pcbs are not a health issue here.
January 10, 2026 at 10:53 PM
iu"health" bought our hospitals- iu gets federal grants 2 study pcb associated disorders they all claim don't exist-partly in their big neurology school.because parkinsons, alzheimer's-etc-are prevalent here with cancers including "rare" ones.atsdr declared deadly pcbs are not a health issue here.
Excessive daytime sleepiness in #Parkinsons is associated with cortical & basal ganglia beta oscillatory activity
www.nature.com/articles/s42...
www.nature.com/articles/s42...
January 10, 2026 at 11:48 AM
Excessive daytime sleepiness in #Parkinsons is associated with cortical & basal ganglia beta oscillatory activity
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"Cross-ancestry proteogenomic analysis reveals shared & ancestry-specific proteomic signatures causally linked to #Parkinsons"; 21 proteins causally associated with PD in Europeans & 8 in East Asians; BST1 emerged as a shared causal protein
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
January 10, 2026 at 11:42 AM
"Cross-ancestry proteogenomic analysis reveals shared & ancestry-specific proteomic signatures causally linked to #Parkinsons"; 21 proteins causally associated with PD in Europeans & 8 in East Asians; BST1 emerged as a shared causal protein
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Interesting: Anti-epileptic medication perampanel reported to significantly increased the level of phosphorylated dynamin1 in the brains of mice, suppressing dynamin-dependent endocytosis of #Parkinsons-associated alpha synuclein PFFs
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 10, 2026 at 10:49 AM
Interesting: Anti-epileptic medication perampanel reported to significantly increased the level of phosphorylated dynamin1 in the brains of mice, suppressing dynamin-dependent endocytosis of #Parkinsons-associated alpha synuclein PFFs
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research finds obstructive sleep apnea is highly prevalent in #Parkinsons (51.4 %) & was associated with a markedly elevated inflammatory & neurodegenerative biomarker profile; CPAP treatment=sig clinical benefits & ⬇️inflammation & glial activation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 8, 2026 at 9:01 AM
New research finds obstructive sleep apnea is highly prevalent in #Parkinsons (51.4 %) & was associated with a markedly elevated inflammatory & neurodegenerative biomarker profile; CPAP treatment=sig clinical benefits & ⬇️inflammation & glial activation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Results from the Prospective E3N Cohort indicate adherence to the Mediterranean (MED) & Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diets are associated with⬇️ #Parkinsons incidence <71 years in♀️
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Adherence to the Mediterranean and Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective E3N Cohort
Objective The evidence regarding adherence to dietary patterns and Parkinson's disease (PD) risk is inconsistent. Because of the long prodromal PD phase, reverse causation represents a major threat ...
onlinelibrary.wiley.com
January 7, 2026 at 8:06 PM
Results from the Prospective E3N Cohort indicate adherence to the Mediterranean (MED) & Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diets are associated with⬇️ #Parkinsons incidence <71 years in♀️
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
New: "Adherence to the MED and MIND diets was associated with lower PD incidence <71 years in women." #parkinsons #neurosky #neurology
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
January 7, 2026 at 6:34 AM
New: "Adherence to the MED and MIND diets was associated with lower PD incidence <71 years in women." #parkinsons #neurosky #neurology
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
People with LRRK2-associated #Parkinsons "exhibit milder cortical thinning compared to sporadic PD, with notable preservation in temporal & occipital regions, suggesting a distinct pattern of neurodegeneration"; Non-manifest carriers=no significant atrophy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
January 3, 2026 at 5:00 PM
People with LRRK2-associated #Parkinsons "exhibit milder cortical thinning compared to sporadic PD, with notable preservation in temporal & occipital regions, suggesting a distinct pattern of neurodegeneration"; Non-manifest carriers=no significant atrophy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
New paper finds age & #Parkinsons-associated α-syn expression jointly determining the motor phenotype in an inducible α-syn oligomer mouse model - intersecting on proteasomal & actin systems; Cdc42 inhibition⬇️motor phenotype
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
January 2, 2026 at 10:12 PM
New paper finds age & #Parkinsons-associated α-syn expression jointly determining the motor phenotype in an inducible α-syn oligomer mouse model - intersecting on proteasomal & actin systems; Cdc42 inhibition⬇️motor phenotype
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Useful review of the small-molecule therapies field for GBA1-associated #Parkinsons; "Clinical trials of GBA1-modulating therapeutics will be challenging with regard to the optimal timing of the intervention & appropriate outcome parameters"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
December 30, 2025 at 6:18 PM
Useful review of the small-molecule therapies field for GBA1-associated #Parkinsons; "Clinical trials of GBA1-modulating therapeutics will be challenging with regard to the optimal timing of the intervention & appropriate outcome parameters"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research finds that #Parkinsons -associated alpha-synuclein amyloids can degrade adenosine triphosphate (ATP) in a catalytic fashion (producing adenosine diphosphate & adenosine monophosphate); Upon prolonged incubation, all ATP is irreversibly consumed
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 28, 2025 at 8:11 PM
New research finds that #Parkinsons -associated alpha-synuclein amyloids can degrade adenosine triphosphate (ATP) in a catalytic fashion (producing adenosine diphosphate & adenosine monophosphate); Upon prolonged incubation, all ATP is irreversibly consumed
www.nature.com/articles/s41...
www.nature.com/articles/s41...
By analysing the membrane proteome for α-syn fibril binding, researchers propose that a cell surface mGluR4–NPDC1 complex participates in the neurodegeneration induced by #Parkinsons -associated alpha synuclein; Transgenic KO mice = protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 25, 2025 at 6:32 PM
By analysing the membrane proteome for α-syn fibril binding, researchers propose that a cell surface mGluR4–NPDC1 complex participates in the neurodegeneration induced by #Parkinsons -associated alpha synuclein; Transgenic KO mice = protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Parkinsons -associated alpha-synuclein co-pathology drives tau accumulation in #Alzheimers patients & iPSCs-derived models
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Alpha‐Synuclein co‐pathology drives tau accumulation in Alzheimer's disease patients and iPSCs‐derived models
Background The molecular basis for accelerated cognitive decline seen in Alzheimer's Disease (AD) cases presenting with cortical alpha-Synuclein co-pathology is not well understood. Mouse experiment...
alz-journals.onlinelibrary.wiley.com
December 25, 2025 at 6:25 PM
#Parkinsons -associated alpha-synuclein co-pathology drives tau accumulation in #Alzheimers patients & iPSCs-derived models
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
New paper reports Helicobacter pylori infection & #Parkinsons -associated α-synuclein pathology drive parallel neurodegen. pathways in the substantia nigra; H. pylori infection doesn't exacerbate α-synucleinopathy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 23, 2025 at 1:43 PM
New paper reports Helicobacter pylori infection & #Parkinsons -associated α-synuclein pathology drive parallel neurodegen. pathways in the substantia nigra; H. pylori infection doesn't exacerbate α-synucleinopathy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
By reanalyzing single-nucleus RNA sequencing data from postmortem #Parkinsons brains, researchers identified a border-associated macrophages subset expressing CD169 that was significantly⬇️in patients (vs controls)
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
December 22, 2025 at 9:54 PM
By reanalyzing single-nucleus RNA sequencing data from postmortem #Parkinsons brains, researchers identified a border-associated macrophages subset expressing CD169 that was significantly⬇️in patients (vs controls)
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
A large review of case reports, case series, & clinicopathological cohorts published between 1990 & 2024 finds #Parkinsons -associated Lewy body pathology is not universally present in genetic variant-associted PD, particularly in LRRK2 & PARKIN mutations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Neuropathology in genetic Parkinson’s disease: a focused review of pathological and clinical findings - Journal of Neural Transmission
Parkinson’s disease (PD) is a neurodegenerative disorder with a complex interaction between genetic and environmental causal factors. The role of Lewy body (LB) pathology (Lewy bodies and neurites) in...
link.springer.com
December 22, 2025 at 9:36 PM
A large review of case reports, case series, & clinicopathological cohorts published between 1990 & 2024 finds #Parkinsons -associated Lewy body pathology is not universally present in genetic variant-associted PD, particularly in LRRK2 & PARKIN mutations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Researchers report the #Parkinsons -associated LRRK2 P1446L mutation triggers dopaminergic neurodegeneration, via DAPK1-mediated microglial neuroinflammation & neuronal apoptosis; DAPK1 inhibition as a promising therapeutic strategy?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 22, 2025 at 11:22 AM
Researchers report the #Parkinsons -associated LRRK2 P1446L mutation triggers dopaminergic neurodegeneration, via DAPK1-mediated microglial neuroinflammation & neuronal apoptosis; DAPK1 inhibition as a promising therapeutic strategy?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research explores immune & metabolic signatures that characterise constipation-driven endophenotypes in #Parkinsons; 2 PD endophenotypes identified by gastro symptoms & T cell phenotypes associated with gut- & brain-tropism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 22, 2025 at 11:20 AM
New research explores immune & metabolic signatures that characterise constipation-driven endophenotypes in #Parkinsons; 2 PD endophenotypes identified by gastro symptoms & T cell phenotypes associated with gut- & brain-tropism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research reports that the #Parkinsons -associated gene FAM49B is critically expressed in microglia of the human substantia nigra pars compacta & it is downregulated with age & PD (associated with⬆️microglial activation)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 20, 2025 at 11:48 PM
New research reports that the #Parkinsons -associated gene FAM49B is critically expressed in microglia of the human substantia nigra pars compacta & it is downregulated with age & PD (associated with⬆️microglial activation)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Using data from the UK Biobank, researchers report "distinct neuroprotective profiles for Omega-3 & Omega-6 fatty acids in neurodegenerative disorders"; Higher Omega-6 level at baseline were associated with a⬇️risk of incident #Parkinsons (HR=0.76)
www.prd-journal.com/article/S135...
www.prd-journal.com/article/S135...
Association of Omega-3 and Omega-6 with neurodegenerative disorders: a UK biobank prospective cohort study
While Omega-3 and Omega-6 fatty acids have been implicated in neurodegenerative disorders
(NDDs), existing epidemiological evidence remains inconclusive. We aim to clarify
these relationships in a lar...
www.prd-journal.com
December 19, 2025 at 4:18 PM
Using data from the UK Biobank, researchers report "distinct neuroprotective profiles for Omega-3 & Omega-6 fatty acids in neurodegenerative disorders"; Higher Omega-6 level at baseline were associated with a⬇️risk of incident #Parkinsons (HR=0.76)
www.prd-journal.com/article/S135...
www.prd-journal.com/article/S135...