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natprodreports.rsc.org
📢Our latest issue is now online!

Check out the review behind the front cover by Jun Deng & co. from Nankai University looking at the recent progress in [5+2] cycloaddition reactions for natural product synthesis #natprod #orgchem

pubs.rsc.org/en/content/a...
November 12, 2025 at 3:13 PM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

Check out the research behind the front cover by Norihiro Tada, Akichika Itoh & co. from Gifu Pharmaceutical University reporting the external base-free electrophilic diynylation of thiols with diynyl benziodoxolone #orgchem

pubs.rsc.org/en/content/a...
November 12, 2025 at 3:11 PM
orgbiomolchem.rsc.org
🔓Don't miss #OpenAccess research in our New Talent collection by Andrew R. Buller & co. from @uwmadison.bsky.social describing the biocatalytic synthesis of β-hydroxy tryptophan regioisomers #orgchem

Check out the full report on our website🔽
Biocatalytic synthesis of β-hydroxy tryptophan regioisomers
We report a biocatalytic strategy to access novel β-hydroxy l-tryptophan regioisomers using an l-threonine transaldolase. We show that classical threonine aldolases cannot perform this…
pubs.rsc.org
November 11, 2025 at 3:45 PM
orgbiomolchem.rsc.org
🔓Be sure to read this #OpenAccess paper by @byrneresearch.bsky.social & co at @ucddublin.bsky.social reporting antiadhesive glycoconjugate metal complexes targeting P. aeruginosa & C. albicans in our New Talent collection #orgchem

Find the full report on our website🔽
pubs.rsc.org/en/content/a...
November 10, 2025 at 10:30 AM
orgbiomolchem.rsc.org
🔓Don't miss #OpenAccess research in our New Talent collection from María Tomás-Gamasa, José L. Mascareñas, @mauromato.bsky.social & co. at @ciqus.bsky.social describing the red-shifted photoredox generation & trapping of alkyl radicals towards bioorthogonality #orgchem
Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality
The photocatalytic generation and trapping of alkyl radicals is a powerful synthetic tool in organic chemistry, but it remains underexplored in biological settings. Here, we present two photoredox…
pubs.rsc.org
November 9, 2025 at 3:01 PM
orgbiomolchem.rsc.org
Check out this review by Emma E. Watson from @monashuniversity.bsky.social in our New Talent collection highlighting different strategies for the optimisation of troublesome peptide nucleic acid sequences #orgchem

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Strategies for the optimisation of troublesome peptide nucleic acid (PNA) sequences
Through the use of a pseudo-peptidic backbone, peptide nucleic acids (PNA) mimic the functionality of native nucleic acids while enjoying improved binding affinity and metabolic stability. However,…
pubs.rsc.org
November 9, 2025 at 9:00 AM
orgbiomolchem.rsc.org
🔓Be sure to read this #OpenAccess by Ken Yamazaki, Tomoya Miura & co. from Okayama University on the photocatalytic α-pyridination of glycyl derivatives harnessing the reactivity of captodative radicals in our New Talent collection #orgchem

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Harnessing the reactivity of captodative radicals: photocatalytic α-pyridination of glycyl derivatives through reversible radical coupling
Captodative radicals that are highly stabilized by the presence of both electron-donating and electron-withdrawing groups exhibit unique reactivity in organic syntheses. These radicals are known to…
pubs.rsc.org
November 8, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Check out in our New Talent collection research by Huifeng Yue et al. from Fuzhou University on the iron-catalyzed C–H bond functionalization into oxime ethers via photo-induced ligand-to-metal charge transfer #orgchem

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Iron-catalyzed C–H bond functionalization into oxime ethers via photo-induced ligand-to-metal charge transfer
We have developed a novel strategy for Fe-catalyzed C–H functionalization into oxime ethers through photo-induced ligand-to-metal charge transfer (LMCT). The method avoids the need for photocatalysts…
pubs.rsc.org
November 7, 2025 at 9:30 AM
orgbiomolchem.rsc.org
🔓Take a look at #OpenAccess research by @chrrademacher.bsky.social, Petra Menova & co. in our New Talent collection describing the synthesis and evaluation of aryl fucosides binding affinity towards the DC-SIGN receptor #orgchem

📍 @univie.ac.at & @vschtpraha.bsky.social
Aryl fucosides: synthesis and evaluation of their binding affinity towards the DC-SIGN receptor
DC-SIGN, a C-type lectin receptor expressed on antigen presenting cells, is crucial for pathogen recognition and immune modulation. While most glycomimetic DC-SIGN ligands are mannose-based,…
pubs.rsc.org
November 6, 2025 at 2:30 PM
orgbiomolchem.rsc.org
Be sure to read this review in our New Talent collection by Cassandra Fleming et al. from @sydney.edu.au discussing the advances in visible-to-NIR activatable photolabile protecting groups #orgchem

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pubs.rsc.org/en/content/a...
Shining light on photo-responsive molecular tools: advances in visible-to-NIR activatable photolabile protecting groups
The utilisation of light as an external stimulus to control the structure and function of bio-relevant molecules in healthy and diseased cells and tissues serves as a valuable means to probe fundament...
pubs.rsc.org
November 6, 2025 at 9:07 AM
orgbiomolchem.rsc.org
Our latest issue has an inside front cover!

Don't miss the #OpenAccess paper from Annyesha Biswas & Saurja DasGupta at @notredame.bsky.social reporting new RNA Mango-based sensors for lead #orgchem

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pubs.rsc.org/en/content/a...
November 5, 2025 at 3:22 PM
natprodreports.rsc.org
Check out this review in our latest issue by Zhimin Hu, Jinxin Wang, Wei-Dong Zhang et al. from the Second Military Medical University discussing photo-/electro-chemical catalysis for late-stage functionalization of alkene-containing natural products #natprod #orgchem
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products
Covering: 2013 to 2024 Alkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms. Strategic alkene modification of NPs not only generates diverse chemical…
pubs.rsc.org
November 4, 2025 at 9:56 AM
orgbiomolchem.rsc.org
Be sure to read in our latest issue this paper by Sujoy Baitalik et al. from Jadavpur University reporting a series of substituted pyridil-imidazole derivatives as red–green–blue as well as white-light emitters #orgchem

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Substituted pyridil-imidazole derivatives as red–green–blue (RGB) as well as white-light emitters
A series of 2-(2-pyridyl)imidazole-based compounds were synthesized via condensation of 2,2′-pyridil with p-substituted benzaldehydes and thoroughly characterized by standard analytical tools and…
pubs.rsc.org
November 4, 2025 at 9:30 AM
orgbiomolchem.rsc.org
🔓Don't miss #OpenAccess research from Rolf Breinbauer & co. at @tugraz.bsky.social on the synthesis and evaluation of naphthoquinone-based probes for activity-based protein profiling of oxidoreductases in our latest issue #orgchem

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Synthesis and evaluation of naphthoquinone-based probes for activity-based protein profiling of oxidoreductases
Activity-based protein profiling (ABPP) has become a highly valuable proteomic technique over the past decades especially in the investigation of hydrolytic enzymes. Oxidoreductases have so far…
pubs.rsc.org
November 3, 2025 at 11:54 AM
orgbiomolchem.rsc.org
🔓Check out in our latest issue this #OpenAccess paper by Baofu Xu et al. from Shanghai Institute of Materia Medica reporting the phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase #secmet #orgchem

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Phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase
Eunicellane diterpenoids, characterized by a 6,10-bicyclic core, are prone to undergo further cyclization into gersemiane diterpenoids via acid- or epoxidation-mediated protonation. However, it…
pubs.rsc.org
November 2, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Be sure to read research from Guillaume Clavé, @smietana-m.bsky.social & co. at @umontpellier.bsky.social on the synthesis, duplex-forming properties and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages #orgchem

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Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages
We report the synthesis of (2-(N-acetylsulfamoyl)ethyl)carbamate (NAC)-linked thymidine dinucleotide via the sulfo-click reaction and its incorporation into DNA oligonucleotides. Thermal denaturation…
pubs.rsc.org
October 31, 2025 at 11:49 AM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

Check out the paper behind the front cover by Francis K. Yoshimoto & co. from @utsaroadrunners.bsky.social & @vanderbilt.edu on the synthesis of 1β-hydroxytestosterone beginning with borylation of boldione #orgchem

pubs.rsc.org/en/content/a...
October 29, 2025 at 3:45 PM
fredlamaty.bsky.social
Program for the next 3 days Orgchem for ever ❤️
October 29, 2025 at 2:32 PM
orgbiomolchem.rsc.org
Be sure to read this review in our latest issue by Adel Nefzi et al. from @fiu.bsky.social covering the recent synthetic advances in the preparation of 1,3-thiazole compounds and their therapeutic applications #orgchem

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Recent synthetic advances in the preparation of 1,3-thiazole compounds and their therapeutic applications in degenerative diseases
The 1,3-thiazole scaffold represents a privileged heterocyclic framework present in a broad spectrum of biologically active molecules and associated with a wide range of pharmacological effects.…
pubs.rsc.org
October 28, 2025 at 3:33 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper by Cally J. E. Haynes & co. from @ucl.ac.uk reporting bis-amino maleimides as a new class of dual hydrogen bond donor for anion binding and transport in our latest issue #orgchem

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Bis-amino maleimides: a new class of dual hydrogen bond donor for anion binding and transport
Dual hydrogen bond donor scaffolds are used in the design of numerous supramolecular receptors and play an important role in the specific recognition, reaction and transport of anionic guests. In…
pubs.rsc.org
October 27, 2025 at 12:31 PM
orgbiomolchem.rsc.org
Check out in our latest issue research from Selena C. L. Gilmer & Andrea J. Vernall @universityofotago.bsky.social using a light-activated tetrazine for bioorthogonal fluorogenic chemistry #orgchem

Read their full report below🔽
Bioorthogonal fluorogenic chemistry using a light-activated tetrazine
Triggerable and fluorogenic bioorthogonal reactions are a powerful tool for a multitude of biological and materials science applications. The concepts of light-activated tetrazines and fluorogenic…
pubs.rsc.org
October 26, 2025 at 9:01 AM
orgbiomolchem.rsc.org
🔓Be sure to read a #OpenAccess paper from Stefano Parisotto et al. at the Università di Torino in our latest issue combining photocatalysis with imine reductases to access stereodefined pyrrolidines from oxime benzoates #orgchem

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Combining photocatalysis with imine reductases to access stereodefined pyrrolidines from oxime benzoates
In this paper, we present the first combination of commercially available imine reductases (IREDs) with the photocatalytic hydroimination of alkene-tethered iminyl radicals. Notably, the…
pubs.rsc.org
October 24, 2025 at 12:02 PM
gianluigialbano.bsky.social
And huge congratulations to our students Federico, Giorgia and Lilia: an important recognition of their dedication and commitment throughout their Bachelor’s Thesis work!

#Chemistry #OrganicChemistry #OrgChem #ChemSky #BlueChem #Research #newPI
October 23, 2025 at 10:29 AM
orgbiomolchem.rsc.org
Don't miss this review in our latest issue from Gedu Satyanarayana et al. at IIT Hyderabad discussing the recent advances in the synthesis of indoles and their applications #orgchem

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Recent advances in the synthesis of indoles and their applications
Indoles are very important heterocyclic scaffolds and they continue to attract substantial attention due to their presence in biologically active compounds, pharmaceuticals, agrochemicals, and…
pubs.rsc.org
October 23, 2025 at 8:48 AM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

Check out the research behind the cover from Yimin Hu & co. at Anhui Normal University describing the formation of complex cyclic compounds via a dehydrogenative Diels–Alder reaction #organicchemistry #orgchem

pubs.rsc.org/en/content/a...
October 22, 2025 at 2:44 PM