#OrgChem
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orgbiomolchem.rsc.org
🔓Don't miss #OpenAccess research in our New Talent collection by Andrew R. Buller & co. from @uwmadison.bsky.social describing the biocatalytic synthesis of β-hydroxy tryptophan regioisomers #orgchem

Check out the full report on our website🔽
Biocatalytic synthesis of β-hydroxy tryptophan regioisomers
We report a biocatalytic strategy to access novel β-hydroxy l-tryptophan regioisomers using an l-threonine transaldolase. We show that classical threonine aldolases cannot perform this…
pubs.rsc.org
November 11, 2025 at 3:45 PM
orgbiomolchem.rsc.org
🔓Don't miss #OpenAccess research in our New Talent collection from María Tomás-Gamasa, José L. Mascareñas, @mauromato.bsky.social & co. at @ciqus.bsky.social describing the red-shifted photoredox generation & trapping of alkyl radicals towards bioorthogonality #orgchem
Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality
The photocatalytic generation and trapping of alkyl radicals is a powerful synthetic tool in organic chemistry, but it remains underexplored in biological settings. Here, we present two photoredox…
pubs.rsc.org
November 9, 2025 at 3:01 PM
orgbiomolchem.rsc.org
Be sure to read this paper by Serhiy V. Ryabukhin & co at Enamine Ltd in our latest issue describing concise practical avenues toward 5,5-spiro-α-prolines #orgchem

Find it in full below👇
Concise practical avenues toward 5,5-spiro-α-prolines
This article describes concise and practical synthetic approaches toward the multigram-scale preparation of value-added conformationally constrained 5-spirocyclic α-prolines from readily accessible…
pubs.rsc.org
April 11, 2025 at 11:33 AM
orgbiomolchem.rsc.org
🔓Be sure to read this #OpenAccess paper in our latest issue from Rachel Codd & co at @sydney.edu.au directing the chemoenzymatic assembly of desferrioxamine B as a single product using N-tert-butoxycarbonyl-protected substrates #orgchem

Find their full report below👇
Directing the chemoenzymatic assembly of desferrioxamine B as a single product using N-tert-butoxycarbonyl-protected substrates
Desferrioxamine B (DFOB, 1) is a clinical hydroxamic acid siderophore used as a chelator to treat acute and secondary iron overload disease, with further applications in metal-based…
pubs.rsc.org
August 1, 2025 at 8:30 AM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

Check out the paper behind the cover by Pushparathinam Gopinath & co. from SRM Institute of Science and Technology on regioselective (3+2) cycloaddition reactions of zerumbone #organicchemistry #orgchem

pubs.rsc.org/en/content/a...
September 10, 2025 at 2:00 PM
orgbiomolchem.rsc.org
🔓Be sure to read #OpenAccess research from Katarzyna Jastrzębska et al. at the Polish Academy of Sciences applying oxathiaphospholane chemistry for the synthesis of morpholino-based phosphorothioate analogs #orgchem

Find their full report below🔽
Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability
We present the application of the oxathiaphospholane method for the synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs, showcasing its potential for creating…
pubs.rsc.org
October 7, 2025 at 11:30 AM
fredlamaty.bsky.social
Program for the next 3 days Orgchem for ever ❤️
October 29, 2025 at 2:32 PM
gnollified.bsky.social
--in space, incl. orgchem reactions, it's hard for me to view life as a common occurrence. it's a bit cliché to argue þat earþ is special, but it really is--þe vast majority of þe solar system's liquid water are in subsurface oceans, many of þem likely cold and very salty; it's disputable as to
May 17, 2025 at 12:59 PM
orgbiomolchem.rsc.org
Take a look at this paper by Yun-Fang Yang et al. in our latest issue using machine learning methods to predict the diabatic bond dissociation energy of non-heme iron complexes #orgchem

📍Zhejiang University of Technology
pubs.rsc.org/en/content/a...
Using machine learning methods to predict the diabatic bond dissociation energy of non-heme iron complexes
Bond dissociation energy (BDE) is an important property in chemical research. In the process of non-heme iron complex catalytic reactions, diabatic BDE has a significant impact on the selectivity of…
pubs.rsc.org
May 17, 2025 at 8:13 AM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

Check out the paper behind the front cover by Francis K. Yoshimoto & co. from @utsaroadrunners.bsky.social & @vanderbilt.edu on the synthesis of 1β-hydroxytestosterone beginning with borylation of boldione #orgchem

pubs.rsc.org/en/content/a...
October 29, 2025 at 3:45 PM
orgbiomolchem.rsc.org
Don't miss this review in our latest issue from Qinghan Li & co at Southwest Minzu University covering the formation reactions of carbon–carbon bonds promoted by Eosin-Y under visible light #orgchem

Check it out here🔽
pubs.rsc.org/en/content/a...
The formation reaction of a carbon–carbon bond promoted by Eosin-Y under visible light
In recent years, photochemical organic conversion promoted by visible light has attracted the interest of many organic chemists. Compared with traditional methods, visible light for the photoredox…
pubs.rsc.org
April 18, 2025 at 8:11 AM
orgbiomolchem.rsc.org
Check out research by Takumi Abe et al. from Okayama University in our latest issue describing the one-pot synthesis of trans-2,3-diaminoindolines through 2,3-diamination of electrophilic indolines #orgchem

Read their full report below👇
One-pot synthesis of trans-2,3-diaminoindolines through 2,3-diamination of electrophilic indolines
Despite recent advances in the synthesis of 2,3-diaminoindole derivatives, construction of 2,3-diaminoindolines, whose two amine moieties on each molecule differ from one another has yet to be…
pubs.rsc.org
July 20, 2025 at 8:11 AM
orgbiomolchem.rsc.org
🔓Read this #OpenAccess paper from Bahaa Elgendy et al. at Washington University in St Louis & @ufresearch.bsky.social on the development of synthetic TLX agonists by iodine-promoted oxidative cross-coupling #orgchem

Find their full report on our website👇
Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C–H activation: development of synthetic TLX agonists
We report the development of an efficient iodine-promoted oxidative cross-coupling reaction for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one derivatives. This…
pubs.rsc.org
August 12, 2025 at 2:48 PM
pioyua.bsky.social
anyway that school didnt have a permit so they shut it down too LMAO and i enrolled late into a normal gov hs. y11 as i shouldve been. late into the semester we had orgchem but by then our teacher stopped trying to do her job. for some reason. i guess she was exhausted
September 24, 2025 at 12:27 PM
orgbiomolchem.rsc.org
Don't miss this review in our latest issue from Gedu Satyanarayana et al. at IIT Hyderabad discussing the recent advances in the synthesis of indoles and their applications #orgchem

Check it out in full here🔽
Recent advances in the synthesis of indoles and their applications
Indoles are very important heterocyclic scaffolds and they continue to attract substantial attention due to their presence in biologically active compounds, pharmaceuticals, agrochemicals, and…
pubs.rsc.org
October 23, 2025 at 8:48 AM
feeberly.bsky.social
I mean, probably snort powdered crystalline estrogen or inject a non-esterized solution, but I'm not an orgchem girl and both seem like bad ideas considering how few mg you need to get a very high estrogen dose
September 24, 2024 at 11:13 PM
orgbiomolchem.rsc.org
Hello BlueSky community 👋 you can now find us @orgbiomolchem.rsc.org!

Follow us for research and reviews on organic synthesis, supramolecular chemistry, chemical biology and more.
#ChemSky #OrgChem #OrganicChemistry
February 28, 2025 at 10:17 AM
orgbiomolchem.rsc.org
Be sure to read this paper in our latest issue from Nagendra K. Sharma & co at NISER Bhubaneswar on the PIDA-mediated synthesis of kynurenine derivatives by oxidative fragmentation of the tryptophan scaffold #orgchem

Find it in full below🔽
PIDA-mediated synthesis of kynurenine derivatives by oxidative fragmentation of the tryptophan scaffold
Kynurenine metabolites are derived from the aromatic amino acid, tryptophan, and their chemical synthesis has been sought to understand the tryptophan–kynurenine-based biochemical reactions that…
pubs.rsc.org
April 1, 2025 at 9:12 AM
orgbiomolchem.rsc.org
Be sure to read this research in our latest issue from Melvin Druelinger, Kenneth J. Olejar & co at Colorado State University Pueblo on the electrophilic fluorination of cannabinol #orgchem

Find it in full here🔽
pubs.rsc.org/en/content/a...
Electrophilic fluorination of cannabinol (CBN)
Several fluorinated cannabinol compounds (3a–g) were synthesised via an electrophilic fluorination process. This resulted in the formation of two mono-fluorinated aromatic ring products, a…
pubs.rsc.org
May 25, 2025 at 2:32 PM
orgbiomolchem.rsc.org
🔓Be sure to read this #OpenAccess paper by @byrneresearch.bsky.social & co at @ucddublin.bsky.social reporting antiadhesive glycoconjugate metal complexes targeting P. aeruginosa & C. albicans in our New Talent collection #orgchem

Find the full report on our website🔽
pubs.rsc.org/en/content/a...
November 10, 2025 at 10:30 AM
uneedabiscuit.bsky.social
This. I struggled with my math throughout school in large part because I figured it was something I "just couldn't do" and was encouraged to focus on non STEM subjects. This was stupid. Jokes on them, tho: I had to take two levels of calc, biostats, and orgchem for my MS. Suck on that Mrs. Smith!
October 13, 2023 at 2:45 PM
orgbiomolchem.rsc.org
🔓Take a look in our Photoswitches & Photopharmacology collection at a #OpenAccess paper from Kimio Sumaru, Kingo Uchida & co. on using a diarylethene photoswitch for photo-controllable cytotoxicity in cell culture #orgchem

📍AIST, Ryukoku University
Photo-controllable cytotoxicity in cell culture using a diarylethene photoswitch
For diarylethene (DAE) derivatives, whose dark cytotoxicity varies greatly depending on their isomerization state, we observe that the non-toxic open-ring isomer taken up by cells is converted to a…
pubs.rsc.org
September 25, 2025 at 8:48 AM
orgbiomolchem.rsc.org
Don't miss this review from Sanaullah & Krzysztof Walczak at the Silesian University of Technology in our latest issue looking at 1,8-naphthalimide derivatives and the multi-applications they have in chemistry and biology #orgchem

Check it out in full on our website🔽
1,8-Naphthalimide derivatives as small molecules with multi-applications in chemistry and biology
1,8-Naphthalimide and its derivatives have attracted attention from scientists because of their ease of synthesis, flexible structural modifications, and notable optical properties such as good…
pubs.rsc.org
July 3, 2025 at 11:48 AM
orgbiomolchem.rsc.org
Our latest issue has an inside front cover!

Don't miss the #OpenAccess paper from Annyesha Biswas & Saurja DasGupta at @notredame.bsky.social reporting new RNA Mango-based sensors for lead #orgchem

Read the full article on our website👇
pubs.rsc.org/en/content/a...
November 5, 2025 at 3:22 PM