💡 #MWClinicalTips
FGFR1-amplified colorectal cancer: a distinct prognostic subtype

✅ Large-scale profiling (n=7606) → FGFR1 amplification = predominant FGFR alteration in CRC (≈4%).
✨ Independent marker of poor prognosis: ↓DFS (HR 2.91) & ↓PFS (HR 2.52).

💡 #MWClinicalTips
Brain imaging screening in metastatic breast cancer: patients’ & physicians’ perspectives

✅ 529 physicians (50 countries): 65% request BIS in asymptomatic MBC, mainly for HER2+ & TNBC

💡 #MWClinicalTips
📢 Advances in Neuroendocrine Tumors (NETs) — therapeutic landscape update

✅ NETs are highly heterogeneous — site of origin & biology determine management.
✅ Somatostatin analogs remain backbone for symptom & tumor control.

💡 #MWClinicalTips
📢 IMvigor011 trial: ctDNA-guided adjuvant immunotherapy in MIBC. Natera & Genentech/Roche

✅ Signatera-positive pts + atezolizumab → significant ↑ DFS & OS
✅ Signatera-negative pts → excellent outcomes w/out adjuvant Rx

🌟💡 #MWClinicalTips ✨
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic & colorectal cancer: phase 1 AMPLIFY-201 trial final results

✅ mKRAS-specific amphiphile vaccines drive robust CD4+ & CD8+ T cell responses in pancreatic & colorectal cancer.