Excited to be heading to #SfN25 soon, to present my poster on GFAP and regional WMH!
Come find me at my poster!
🧠 Session Number: PSTR323
🗓️ Session Date/Time: Tuesday, Nov. 18, 2025, 1:00 - 5:00 PM
📍Location/Room: SDCC Halls B-H
(Wish I brought my #brainart there too! 😂)
#WhitmerLab
Come find me at my poster!
🧠 Session Number: PSTR323
🗓️ Session Date/Time: Tuesday, Nov. 18, 2025, 1:00 - 5:00 PM
📍Location/Room: SDCC Halls B-H
(Wish I brought my #brainart there too! 😂)
#WhitmerLab
November 11, 2025 at 12:59 AM
Excited to be heading to #SfN25 soon, to present my poster on GFAP and regional WMH!
Come find me at my poster!
🧠 Session Number: PSTR323
🗓️ Session Date/Time: Tuesday, Nov. 18, 2025, 1:00 - 5:00 PM
📍Location/Room: SDCC Halls B-H
(Wish I brought my #brainart there too! 😂)
#WhitmerLab
Come find me at my poster!
🧠 Session Number: PSTR323
🗓️ Session Date/Time: Tuesday, Nov. 18, 2025, 1:00 - 5:00 PM
📍Location/Room: SDCC Halls B-H
(Wish I brought my #brainart there too! 😂)
#WhitmerLab
Happy #FluorescenceFriday from these primary astrocytes grown on glass slides and robotically stained on the Biocare Oncore Pro X! 🧠🔬🧪
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
November 7, 2025 at 7:26 PM
Happy #FluorescenceFriday from these primary astrocytes grown on glass slides and robotically stained on the Biocare Oncore Pro X! 🧠🔬🧪
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
November 7, 2025 at 12:37 PM
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
Gracias 🙏 😍🎉!!
Thank you Dr. Francisco Capani, Dr. Juan Pablo Luaces y Demilson Huerta © the Centro de Altos Estudios en Ciencia Humanas y de la Salud - Sede Buenos Aires for a wonderful, informative tour 😃🧠🔬👀💚
#neuroscience #teaching #outreach #argentina 🤓
Thank you Dr. Francisco Capani, Dr. Juan Pablo Luaces y Demilson Huerta © the Centro de Altos Estudios en Ciencia Humanas y de la Salud - Sede Buenos Aires for a wonderful, informative tour 😃🧠🔬👀💚
#neuroscience #teaching #outreach #argentina 🤓
November 7, 2025 at 12:25 PM
Gracias 🙏 😍🎉!!
Thank you Dr. Francisco Capani, Dr. Juan Pablo Luaces y Demilson Huerta © the Centro de Altos Estudios en Ciencia Humanas y de la Salud - Sede Buenos Aires for a wonderful, informative tour 😃🧠🔬👀💚
#neuroscience #teaching #outreach #argentina 🤓
Thank you Dr. Francisco Capani, Dr. Juan Pablo Luaces y Demilson Huerta © the Centro de Altos Estudios en Ciencia Humanas y de la Salud - Sede Buenos Aires for a wonderful, informative tour 😃🧠🔬👀💚
#neuroscience #teaching #outreach #argentina 🤓
#Article in #MedComm
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...
#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...
#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy
Hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) insertion constitutes a frequent and severe complication, however, biomarkers are currently scarce. The results ...
doi.org
November 7, 2025 at 8:23 AM
#Article in #MedComm
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...
#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...
#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP
🩸 New #TBI biomarker signal
EV-GFAP in blood rises after TBI and relates to CT findings, flagging acute injury. Other EV markers were less helpful here, and plasma #GFAP still works well. We need more studies to learn when EVs add value for patients.
#Biomarkers #EVs #BrainInjury #Science 🧪
EV-GFAP in blood rises after TBI and relates to CT findings, flagging acute injury. Other EV markers were less helpful here, and plasma #GFAP still works well. We need more studies to learn when EVs add value for patients.
#Biomarkers #EVs #BrainInjury #Science 🧪
Extracellular Vesicle Glial Fibrillary Acidic Protein as a Circulating Biomarker of Traumatic Brain Injury Severity - Journal of Molecular Neuroscience
Traumatic brain injury (TBI) remains a major global health challenge with a need for improved diagnostic and prognostic biomarkers. This study aimed to evaluate the biomarker potential of extracellula...
link.springer.com
November 4, 2025 at 10:43 AM
🩸 New #TBI biomarker signal
EV-GFAP in blood rises after TBI and relates to CT findings, flagging acute injury. Other EV markers were less helpful here, and plasma #GFAP still works well. We need more studies to learn when EVs add value for patients.
#Biomarkers #EVs #BrainInjury #Science 🧪
EV-GFAP in blood rises after TBI and relates to CT findings, flagging acute injury. Other EV markers were less helpful here, and plasma #GFAP still works well. We need more studies to learn when EVs add value for patients.
#Biomarkers #EVs #BrainInjury #Science 🧪
ha not GFAP.
October 31, 2025 at 7:21 PM
ha not GFAP.
By the orientation of the putative GFAP labeling it looks like it is in a fiber tract. Good guess?
October 31, 2025 at 12:57 PM
By the orientation of the putative GFAP labeling it looks like it is in a fiber tract. Good guess?
🚑Diagnosing Stroke in the Ambulance
The DIAGNOSIS study aims to detect brain bleeds before hospital arrival.
Combining clinical signs with GFAP testing could transform early stroke care.
🙋 PCPIE members shared views on data use & meaningful outcomes.
🔗https://t.co/zBhgMHlT9j
The DIAGNOSIS study aims to detect brain bleeds before hospital arrival.
Combining clinical signs with GFAP testing could transform early stroke care.
🙋 PCPIE members shared views on data use & meaningful outcomes.
🔗https://t.co/zBhgMHlT9j
October 29, 2025 at 1:34 PM
🚑Diagnosing Stroke in the Ambulance
The DIAGNOSIS study aims to detect brain bleeds before hospital arrival.
Combining clinical signs with GFAP testing could transform early stroke care.
🙋 PCPIE members shared views on data use & meaningful outcomes.
🔗https://t.co/zBhgMHlT9j
The DIAGNOSIS study aims to detect brain bleeds before hospital arrival.
Combining clinical signs with GFAP testing could transform early stroke care.
🙋 PCPIE members shared views on data use & meaningful outcomes.
🔗https://t.co/zBhgMHlT9j
Double posting for #FluorescenceFriday today, because I am in love w/ this particular astrocyte (marked w/ GFAP in 🔴) that is sitting in dorsal anterior cingulate cortex in the human 🧠. Image credit to Staff Scientist/image analyst Maddy Tippani and JHU grad student @shkwon-bcmbneuro.bsky.social 🔬🧪
October 24, 2025 at 2:35 PM
Double posting for #FluorescenceFriday today, because I am in love w/ this particular astrocyte (marked w/ GFAP in 🔴) that is sitting in dorsal anterior cingulate cortex in the human 🧠. Image credit to Staff Scientist/image analyst Maddy Tippani and JHU grad student @shkwon-bcmbneuro.bsky.social 🔬🧪
Dx Glial fibrillation acidic protein astricytopathy GFAP-A. CT may show linear radial perivascular enhancement
October 20, 2025 at 7:39 PM
Dx Glial fibrillation acidic protein astricytopathy GFAP-A. CT may show linear radial perivascular enhancement
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
October 15, 2025 at 7:49 AM
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
Image Quiz!
The tumor shown was resected from the cervical spine of a patient. The tumor cells express S100 and GFAP and are negative for Olig2. The tumor has a central spinal cord location on MRI, and the presence of a cleavage plane is noted. What is the diagnosis?
(Continued in thread)
The tumor shown was resected from the cervical spine of a patient. The tumor cells express S100 and GFAP and are negative for Olig2. The tumor has a central spinal cord location on MRI, and the presence of a cleavage plane is noted. What is the diagnosis?
(Continued in thread)
October 14, 2025 at 6:21 PM
Image Quiz!
The tumor shown was resected from the cervical spine of a patient. The tumor cells express S100 and GFAP and are negative for Olig2. The tumor has a central spinal cord location on MRI, and the presence of a cleavage plane is noted. What is the diagnosis?
(Continued in thread)
The tumor shown was resected from the cervical spine of a patient. The tumor cells express S100 and GFAP and are negative for Olig2. The tumor has a central spinal cord location on MRI, and the presence of a cleavage plane is noted. What is the diagnosis?
(Continued in thread)
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
October 14, 2025 at 5:06 PM
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
Session Highlights:
- Pre-hospital GFAP biomarker in ICH
- Code-ICH and hospital CARE
- Where next in blood pressure lowering in ICH?
🔗Register: https://worldstrokecongress.org/registration/
#stroke #neurology
- Pre-hospital GFAP biomarker in ICH
- Code-ICH and hospital CARE
- Where next in blood pressure lowering in ICH?
🔗Register: https://worldstrokecongress.org/registration/
#stroke #neurology
October 14, 2025 at 3:21 PM
Session Highlights:
- Pre-hospital GFAP biomarker in ICH
- Code-ICH and hospital CARE
- Where next in blood pressure lowering in ICH?
🔗Register: https://worldstrokecongress.org/registration/
#stroke #neurology
- Pre-hospital GFAP biomarker in ICH
- Code-ICH and hospital CARE
- Where next in blood pressure lowering in ICH?
🔗Register: https://worldstrokecongress.org/registration/
#stroke #neurology
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
October 14, 2025 at 1:05 PM
#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @plosbiology.org 🧪 plos.io/3WHTnFb
Many distal ends are enriched in GFAP.
We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons.
7/x
We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons.
7/x
October 13, 2025 at 8:44 PM
Many distal ends are enriched in GFAP.
We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons.
7/x
We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons.
7/x
We isolated astrocytes using the immunopanning method. Most images are from cells grown in serum-free media for ~2 weeks... they make beautiful processes!
Microtubules & GFAP dominate in thick long primary processes.
And we see a novel actin structure - reticular webbing!
2/x
Microtubules & GFAP dominate in thick long primary processes.
And we see a novel actin structure - reticular webbing!
2/x
October 13, 2025 at 8:44 PM
We isolated astrocytes using the immunopanning method. Most images are from cells grown in serum-free media for ~2 weeks... they make beautiful processes!
Microtubules & GFAP dominate in thick long primary processes.
And we see a novel actin structure - reticular webbing!
2/x
Microtubules & GFAP dominate in thick long primary processes.
And we see a novel actin structure - reticular webbing!
2/x
Excited to share our preprint on cytoskeletal organization in astrocytes!
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
https://biorxiv.org/content/10.110…
October 13, 2025 at 8:44 PM
Excited to share our preprint on cytoskeletal organization in astrocytes!
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
La Passeggiata in Rosa per la Vita invade la città: in 1500 in cammino per la prevenzione e per la solidarietà
vivere.me/gfAp-k
vivere.me/gfAp-k
La Passeggiata in Rosa per la Vita invade la città: in 1500 in cammino per la prevenzione e per la solidarietà
Un'altra edizione record per la Passeggiata in Rosa per la Vita, che si è tenuta ieri mattina a Senigallia. Circa 1500 le donne, le famiglie, i gruppi, i bambini e anche gli amici a quattro zampe che ...
vivere.me
October 13, 2025 at 8:15 AM
La Passeggiata in Rosa per la Vita invade la città: in 1500 in cammino per la prevenzione e per la solidarietà
vivere.me/gfAp-k
vivere.me/gfAp-k
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
October 12, 2025 at 8:44 PM
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
www.theguardian.com/environment/...
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
The plastic inside us: how microplastics may be reshaping our bodies and minds
The particles are in our blood, brains and guts – and scientists are only beginning to learn what they do
www.theguardian.com
October 12, 2025 at 7:44 AM
www.theguardian.com/environment/...
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
When the mice were dissected, plastic was found in every organ, including the brain, where a key protein linked to brain health, GFAP, was depleted – mirroring a pattern seen in depression and dementia.
These reference values are crucial for interpreting GFAP levels in clinical settings, enabling early detection of neurological conditions and informing personalized treatment approaches.
October 8, 2025 at 7:26 PM
These reference values are crucial for interpreting GFAP levels in clinical settings, enabling early detection of neurological conditions and informing personalized treatment approaches.
Importantly, GFAP levels were found to increase with age, with sex-related differences emerging after 50 years.
October 8, 2025 at 7:26 PM
Importantly, GFAP levels were found to increase with age, with sex-related differences emerging after 50 years.
This study analytically validated the MSD S-Plex® GFAP immunoassay for plasma and established age-stratified reference intervals in a healthy population. The assay demonstrated strong performance, with low variability and a wide measurement range.
October 8, 2025 at 7:26 PM
This study analytically validated the MSD S-Plex® GFAP immunoassay for plasma and established age-stratified reference intervals in a healthy population. The assay demonstrated strong performance, with low variability and a wide measurement range.