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dmmjournal.bsky.social
Ting Deng & co from @cam.ac.uk show that in #Drosophila and in human cells, loss of ribosomal S6 kinases causes mitochondrial dysfunction and cell death, providing insights into the mechanisms underlying neurodegeneration. doi.org/10.1242/dmm....
Drosophila S6kII knockout (KO) flies show mitochondrial fragmentation and decreased mitochondrial function in neuronal tissues. (A) Expression levels of S6kII in different tissues of adult Drosophila male flies. Enrichment is defined as a measure of the abundance of S6kII in a particular tissue relative to the whole fly. Results from a query to FlyAtlas 2 (Krause et al., 2022). (B) Schematic diagram of the Drosophila larval central nervous system (CB, central brain; VNC, ventral nerve cord). (C,D) The loss of S6kII results in mitochondrial fragmentation. (C) Confocal analysis of mitoGFP fluorescence in larval VNC axons. (D) Quantification of mitochondrial length is shown as a combined violin and box plot (medians with interquartile ranges; ****P≤0.0001, two-tailed unpaired t-test). (E) A schematic of the adult Drosophila brain in the sagittal orientation. (F,G) The loss of mitochondrial membrane potential (Δψm) in the brain mitochondria of S6kII KO flies. (F) Representative confocal images of whole-mounted brains showing neurons loaded with tetramethylrhodamine methyl ester (TMRM). The intensity levels of TMRM are mapped using the Fire Lookup Table in Fiji. (G) Quantification of the loss of Δψm (means±s.e.m.; ****P≤0.0001, two-tailed unpaired t-test). (H) Decreased lifespan in S6kII KO flies. Fly viability was scored over a period of 80 days. Genotypes: w; elavGal4/+; UASmitoGFP/+ (control), S6kIIKO; elavGal4/+; UASmitoGFP/+ (S6kII KO) (C,D); w1118; +; + (control), S6kIIKO; +; + (S6kII KO) (F–H).
October 12, 2025 at 1:27 PM
bcmgenetics.bsky.social
Congratulations to Dr. Hongjie Li and Dr. Lilei Zhang! Both received 2025 Debakey Excellence in Research Awards
@bcmhouston.bsky.social today for their work with the #FlyAtlas (Li) and #CardiacMetabolism (Zhang)
June 24, 2025 at 9:59 PM
flybase.bsky.social
We’ve added colorblind-friendly palettes for expression data plots
Expression data plots for high-throughput expression data in Gene Reports now have an option to choose from a selection of color palettes.
FlyBase display of FlyAtlas Anatomy Microarray data for the gene Ras85D, displayed back-to-back (larval expression levels on the left, adult expression levels on the right), using the original FlyBase color palette. The color palatte selector is boxed in purple. FlyBase display of FlyAtlas Anatomy Microarray data for the gene Ras85D, displayed back-to-back (larval expression levels on the left, adult expression levels on the right), using the Viridis color palette. The color palette selector is opened to show all options. FlyBase display of FlyAtlas Anatomy Microarray data for the gene Ras85D, displayed back-to-back (larval expression levels on the left, adult expression levels on the right), using the Viridis Reverse color palette. The color palette selector is opened to show all options.
February 23, 2024 at 7:00 PM