Zwartlab NKI
@zwartlab.bsky.social
Epigenetics | hormone receptors | transcriptional regulation | hormone-driven cancers | Netherlands Cancer Institute | University of Technology Eindhoven | Oncode Institute | Cancer Core Europe |Amsterdam, The Netherlands
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations - PubMed
In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.
pubmed.ncbi.nlm.nih.gov
May 10, 2025 at 1:41 PM
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
Check out our latest paper! WGS on 378 metastases of patients with prostate cancer. Biggest findings: 1. Non-coding mutations converge on DNA damage repair 2. Coding mutations defer between metastatic sites, with potential implications on systemic therapy selection.
pubmed.ncbi.nlm.nih.gov/40114169/
pubmed.ncbi.nlm.nih.gov/40114169/
Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications - PubMed
NCT01855477.
pubmed.ncbi.nlm.nih.gov
March 21, 2025 at 7:15 PM
Check out our latest paper! WGS on 378 metastases of patients with prostate cancer. Biggest findings: 1. Non-coding mutations converge on DNA damage repair 2. Coding mutations defer between metastatic sites, with potential implications on systemic therapy selection.
pubmed.ncbi.nlm.nih.gov/40114169/
pubmed.ncbi.nlm.nih.gov/40114169/
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...
www.biorxiv.org
February 17, 2025 at 3:21 PM
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
What do steroid hormone receptor action and DNA damage repair have in common? Check out our latest review in @cp-trendsmolecmed.bsky.social!
pubmed.ncbi.nlm.nih.gov/39934021/
pubmed.ncbi.nlm.nih.gov/39934021/
The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer
Human cells potentiate highly diverse functions through tight transcriptional regulation
and maintenance of genome integrity. While the DNA damage response (DDR) safeguards
the genome, ligand-activate...
www.cell.com
February 13, 2025 at 7:18 PM
What do steroid hormone receptor action and DNA damage repair have in common? Check out our latest review in @cp-trendsmolecmed.bsky.social!
pubmed.ncbi.nlm.nih.gov/39934021/
pubmed.ncbi.nlm.nih.gov/39934021/
Reposted by Zwartlab NKI
🌟 Spots are limited—register now! 🌟
Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research.
Register today: www.grc.org/cancer-genet...
Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research.
Register today: www.grc.org/cancer-genet...
2025 Cancer Genetics and Epigenetics Conference GRC
The 2025 Gordon Research Conference on Cancer Genetics and Epigenetics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 28, 2025 at 3:48 PM
🌟 Spots are limited—register now! 🌟
Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research.
Register today: www.grc.org/cancer-genet...
Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research.
Register today: www.grc.org/cancer-genet...
Looking forward visiting @inem-necker.bsky.social and @goffinlab.bsky.social! Great day of talking science and meeting scientists in the beautiful city of Paris; whats not to like? 😁
🗓️ Join us on Friday, Jan 24, for a #seminar with Wilbert Zwart @zwartlab.bsky.social, Professor of Functional Genomics in Oncology at TU Eindhoven and Group leader at The Netherlands Cancer Institute. Prof. Zwart will explore Hormones, Epigenetics and Cancer. 🧬Don’t miss it! @goffinlab.bsky.social
January 22, 2025 at 8:24 PM
Looking forward visiting @inem-necker.bsky.social and @goffinlab.bsky.social! Great day of talking science and meeting scientists in the beautiful city of Paris; whats not to like? 😁
Reposted by Zwartlab NKI
I'm pleased to announce that the ASCO/Conquer Cancer Foundation Felix Feng Prostate Cancer YIA is now fully endowed and will fund a young prostate cancer investigator every year, in perpetuity. The First Felix Feng YIA recipient will be announced this spring and celebrated at ASCO's annual meeting.
December 19, 2024 at 12:16 AM
I'm pleased to announce that the ASCO/Conquer Cancer Foundation Felix Feng Prostate Cancer YIA is now fully endowed and will fund a young prostate cancer investigator every year, in perpetuity. The First Felix Feng YIA recipient will be announced this spring and celebrated at ASCO's annual meeting.
Reposted by Zwartlab NKI
In Memory of Dr Felix Feng, our beloved friend and a giant in prostate cancer @ericsmall.bsky.social @ucsfcancer.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In Memory of Dr. Felix Feng
www.sciencedirect.com
January 7, 2025 at 11:33 PM
In Memory of Dr Felix Feng, our beloved friend and a giant in prostate cancer @ericsmall.bsky.social @ucsfcancer.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...