We hope that these findings will increase awareness of antipsychotic drug-induced dysregulations in glucose homeostasis alongside ongoing metabolic monitoring and potential treatment.

This is the largest systematic review to date examining disruptions in glycemic control associated with #antipsychotic drugs. We show that that antipsychotic drug treatment significantly disrupts glucose homeostasis independent of exposure time, dose, diagnosis, and weight gain.

In this new study, we discovered sex-specific and regional differences in mitochondrial generation of cytotoxic reactive oxygen species and their relevance to dopamine neuron resilience.