Zeshi
@zeshi.bsky.social
Freelance QA/ administrator game & app tester. Here for the things I like and the people I vibe with! There be tasteful art smutt about Yee been warned! 🦖🦦🐈⬛🎮🏳️🌈🔞 21+
Pinned
Reposted by Zeshi
Reposted by Zeshi
Dawni is looking forward to the cat show and enjoying our solo time in Astoria!
Wish her luck! She placed best in a show with 3x as many cats, so if she decides she's in a good mood, she'll nail this!
#cats
Wish her luck! She placed best in a show with 3x as many cats, so if she decides she's in a good mood, she'll nail this!
#cats
November 22, 2025 at 3:33 AM
Dawni is looking forward to the cat show and enjoying our solo time in Astoria!
Wish her luck! She placed best in a show with 3x as many cats, so if she decides she's in a good mood, she'll nail this!
#cats
Wish her luck! She placed best in a show with 3x as many cats, so if she decides she's in a good mood, she'll nail this!
#cats
Ahhh omg I love these!!! Gonna have some fun thinking of what I'm gonna make in my scrapbook 🤩 @shop.zandraillustration.com @catmintstudios.bsky.social
November 21, 2025 at 10:21 PM
Ahhh omg I love these!!! Gonna have some fun thinking of what I'm gonna make in my scrapbook 🤩 @shop.zandraillustration.com @catmintstudios.bsky.social
Reposted by Zeshi
The brainworm won
November 21, 2025 at 9:37 PM
The brainworm won
Reposted by Zeshi
You can read all this and more here:
• pubs.acs.org/doi/10.1021/...
• www.nature.com/articles/d41...
• scitechdaily.com/100x-more-po...
• www.sciencedaily.com/releases/202...
• www.bbc.com/news/article...
• www.sciencealert.com/powerful-new...
• www.eurekalert.org/news-release...
• pubs.acs.org/doi/10.1021/...
• www.nature.com/articles/d41...
• scitechdaily.com/100x-more-po...
• www.sciencedaily.com/releases/202...
• www.bbc.com/news/article...
• www.sciencealert.com/powerful-new...
• www.eurekalert.org/news-release...
November 16, 2025 at 9:45 PM
Reposted by Zeshi
With its straightforward chemical structure, strong antibacterial power, apparent resistance-proof profile, and scalable production process, pre-methylenomycin C lactone stands out as a promising new candidate.
November 16, 2025 at 7:47 PM
With its straightforward chemical structure, strong antibacterial power, apparent resistance-proof profile, and scalable production process, pre-methylenomycin C lactone stands out as a promising new candidate.
Reposted by Zeshi
By identifying and testing intermediates in the pathways to diverse natural compounds, we may find potent new antibiotics with more resilience to resistance that will aid us in the fight against antimicrobial resistance.
November 16, 2025 at 7:46 PM
By identifying and testing intermediates in the pathways to diverse natural compounds, we may find potent new antibiotics with more resilience to resistance that will aid us in the fight against antimicrobial resistance.
Reposted by Zeshi
Researchers also see potential in looking at the intermediates of other antibiotics.
November 16, 2025 at 7:46 PM
Researchers also see potential in looking at the intermediates of other antibiotics.
Reposted by Zeshi
The next step in the development of pre-methylenomycin C lactone will be pre-clinical testing and lab-testing to fully understand its potential as an antibiotic- both in the mechanisms through which it works and the pathogen targets that it hits.
November 16, 2025 at 7:42 PM
The next step in the development of pre-methylenomycin C lactone will be pre-clinical testing and lab-testing to fully understand its potential as an antibiotic- both in the mechanisms through which it works and the pathogen targets that it hits.
Reposted by Zeshi
With experts increasingly worried about antibiotic resistance -already responsible for millions of deaths each year- the need for new and resilient drugs to tackle infections is urgent, as bacteria continue to evolve.
![Figure 6. Extracted ion chromatograms (EICs) at m/z = 183.065 ± 0.005 corresponding to [M + H]+ for 1 from UHPLC-ESI-Q-ToF-MS analyses of methanol extracts from S. coelicolor W302 (bottom panel) and W301 (middle panel) fed with 2. The top panel shows the EIC at m/z = 183.065 ± 0.005 for an authentic standard of 1.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:llgfbjvsqkaicezsf7mzjxr3/bafkreibw2zepdei54ondl3jtng274x67vr2auct6oitl35acf5hy7enp74@jpeg)
November 16, 2025 at 7:42 PM
With experts increasingly worried about antibiotic resistance -already responsible for millions of deaths each year- the need for new and resilient drugs to tackle infections is urgent, as bacteria continue to evolve.
Reposted by Zeshi
What's particularly promising is that Enterococcus bacteria exposed to pre-methylenomycin C lactone for 28 days straight DID NOT become resistant to it, suggesting the compound could remain effective over the long term.
November 16, 2025 at 7:39 PM
What's particularly promising is that Enterococcus bacteria exposed to pre-methylenomycin C lactone for 28 days straight DID NOT become resistant to it, suggesting the compound could remain effective over the long term.
Reposted by Zeshi
Staphylococcus aureus and Enterococcus faecium, the bacterial species responsible for Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE), two of the infections proving most troublesome for existing antibiotics.
November 16, 2025 at 7:39 PM
Staphylococcus aureus and Enterococcus faecium, the bacterial species responsible for Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE), two of the infections proving most troublesome for existing antibiotics.
Reposted by Zeshi
When tested, one of these intermediates- pre-methylenomycin C lactone- proved to be OVER 100 times more active against a range of Gram-positive bacteria (the kind that are getting smarter at outwitting our current antibiotics) than methylenomycin A. It was particularly effective against
November 16, 2025 at 7:37 PM
When tested, one of these intermediates- pre-methylenomycin C lactone- proved to be OVER 100 times more active against a range of Gram-positive bacteria (the kind that are getting smarter at outwitting our current antibiotics) than methylenomycin A. It was particularly effective against
Reposted by Zeshi
been synthesized several times, no-one appears to have tested the synthetic intermediates for antimicrobial activity. By deleting biosynthetic genes, researchers discovered two previously unknown biosynthetic intermediates, both of which are much more potent antibiotics than methylenomycin A itself.
![Figure 3. Extracted ion chromatograms at m/z = 139.0700 ± 0.005 (corresponding to the [M-CO2+H]+ ion of 1) and m/z = 167.070 ± 0.005 (corresponding to the [M + H]+ ions of 2 and 5 and the [M-H2O+H]+ ion of 6) from positive ion mode LC-MS analyses of neutral extracts (pH 5.5) of S. coelicolor M145 (bottom), W95 (second from bottom), W86 (third from bottom), W89 (third from top), W100 (second from top), and W108 (top).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:llgfbjvsqkaicezsf7mzjxr3/bafkreie77gi7gq3xauixhjfk24j6nse24wcr3pj7f5bkrlzqanv5js5clq@jpeg)
November 16, 2025 at 7:37 PM
been synthesized several times, no-one appears to have tested the synthetic intermediates for antimicrobial activity. By deleting biosynthetic genes, researchers discovered two previously unknown biosynthetic intermediates, both of which are much more potent antibiotics than methylenomycin A itself.
Reposted by Zeshi
discovery of a potent new antibiotic called pre-methylenomycin C lactone. The compound had been "hiding in plain sight" as an intermediate chemical in the natural process that produces the known antibiotic methylenomycin A. Methylenomycin A was originally discovered 50 YEARS AGO and while it has
November 16, 2025 at 7:34 PM
discovery of a potent new antibiotic called pre-methylenomycin C lactone. The compound had been "hiding in plain sight" as an intermediate chemical in the natural process that produces the known antibiotic methylenomycin A. Methylenomycin A was originally discovered 50 YEARS AGO and while it has
Reposted by Zeshi
antibiotics is costly and offers limited financial reward, few pharmaceutical companies are investing in this critical area. In a recent paper in the Journal of the American Chemical Society, researchers from the Monash Warwick Alliance Combatting Emerging Superbug Threats Initiative reported the
November 16, 2025 at 7:34 PM
antibiotics is costly and offers limited financial reward, few pharmaceutical companies are investing in this critical area. In a recent paper in the Journal of the American Chemical Society, researchers from the Monash Warwick Alliance Combatting Emerging Superbug Threats Initiative reported the
Reposted by Zeshi
Antimicrobial resistance (AMR) is considered one of the most serious threats to global health. The World Health Organization (WHO) recently warned that there are "too few antibacterials in the pipeline" and that most easily discoverable antibiotics have already been found. Because developing new
November 16, 2025 at 7:33 PM
Antimicrobial resistance (AMR) is considered one of the most serious threats to global health. The World Health Organization (WHO) recently warned that there are "too few antibacterials in the pipeline" and that most easily discoverable antibiotics have already been found. Because developing new
Reposted by Zeshi
Chemists discovered a powerful hidden antibiotic that’s 100 times stronger than existing ones and effective against deadly superbugs.
The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...
🧪🧵⬇️
The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...
🧪🧵⬇️
November 16, 2025 at 7:32 PM
Chemists discovered a powerful hidden antibiotic that’s 100 times stronger than existing ones and effective against deadly superbugs.
The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...
🧪🧵⬇️
The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...
🧪🧵⬇️
Reposted by Zeshi
THIS IS HUGE! Researchers have just identified a powerful new antibiotic that is 100x STRONGER than existing drugs against deadly superbugs like MRSA and VRE. Hiding in a well-known soil bacterium, pre-methylenomycin C lactone KILLS drug-resistant bacteria WITHOUT triggering resistance.
November 16, 2025 at 7:30 PM
THIS IS HUGE! Researchers have just identified a powerful new antibiotic that is 100x STRONGER than existing drugs against deadly superbugs like MRSA and VRE. Hiding in a well-known soil bacterium, pre-methylenomycin C lactone KILLS drug-resistant bacteria WITHOUT triggering resistance.
Reposted by Zeshi
i dont do thanksgiving but i do partake in goo cylinder
My #SuperlativeCannedGoo tweet from the old place is making rounds again. Support co-op cranberry growers!
November 17, 2025 at 4:36 AM
i dont do thanksgiving but i do partake in goo cylinder
Reposted by Zeshi
I keep thinking about a person who told me they thought I drew cats kinda like weird little goblins and wondered why until they saw my cats, and how funny that is.
My style:
my inspiration:
#catdoodle
#artpost
My style:
my inspiration:
#catdoodle
#artpost
November 21, 2025 at 12:45 AM
I keep thinking about a person who told me they thought I drew cats kinda like weird little goblins and wondered why until they saw my cats, and how funny that is.
My style:
my inspiration:
#catdoodle
#artpost
My style:
my inspiration:
#catdoodle
#artpost
Reposted by Zeshi
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November 19, 2025 at 5:26 PM
Yatta-Tachi's 2025 Reader's Survey
Here's your chance to let us know what you would like to see more or less of on Yatta-Tachi!
Survey closes: Friday, December 19th, 5PM Eastern
docs.google.com/forms/d/e/1F...
Here's your chance to let us know what you would like to see more or less of on Yatta-Tachi!
Survey closes: Friday, December 19th, 5PM Eastern
docs.google.com/forms/d/e/1F...
Reposted by Zeshi
BIG NEWS: The Senate received the bill to release the Epstein Files from the House and passed it instantly under yesterday’s unanimous consent agreement. It now heads to Trump’s desk.
November 19, 2025 at 3:23 PM
BIG NEWS: The Senate received the bill to release the Epstein Files from the House and passed it instantly under yesterday’s unanimous consent agreement. It now heads to Trump’s desk.
Reposted by Zeshi
Kind of obsessed with this particular sticker not gonna lie
November 18, 2025 at 4:08 PM
Kind of obsessed with this particular sticker not gonna lie