Yosef (Yossi) Buganim
@yossibuganim.bsky.social
Scientist, interested in epigenetic reprogramming, cellular rejuvenation, and embryogenesis. Head of a stem cell lab at the Hebrew University of Jerusalem and co-founder and CSO at Ananda Labs
https://www.buganimlab.com/
https://www.ananda-labs.bio
https://www.buganimlab.com/
https://www.ananda-labs.bio
Congrats Yaniv and team
January 10, 2025 at 5:55 AM
Congrats Yaniv and team
Thank you Yaniv!
December 18, 2024 at 5:47 PM
Thank you Yaniv!
December 18, 2024 at 5:40 PM
(4/n) Huge kudos to the amazing members of the Buganim and Soufi labs for their incredible efforts! 🙌 I truly believe this work redefines our understanding of how cell type-specific gene expression is orchestrated and how cell fate determination is established. 🌟
December 18, 2024 at 5:37 PM
(4/n) Huge kudos to the amazing members of the Buganim and Soufi labs for their incredible efforts! 🙌 I truly believe this work redefines our understanding of how cell type-specific gene expression is orchestrated and how cell fate determination is established. 🌟
(3/n) Our study reveals that transcription factor combinations use distinct strategies to locate enhancers:
• OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
• GETM factors use looping junctions to locate trophectoderm enhancers.
• OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
• GETM factors use looping junctions to locate trophectoderm enhancers.
December 18, 2024 at 5:36 PM
(3/n) Our study reveals that transcription factor combinations use distinct strategies to locate enhancers:
• OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
• GETM factors use looping junctions to locate trophectoderm enhancers.
• OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
• GETM factors use looping junctions to locate trophectoderm enhancers.
(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.
December 18, 2024 at 5:36 PM
(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.
(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.
December 18, 2024 at 5:22 PM
(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.