Yifei Cai
@yifeicai.bsky.social
Yale Neuroscientist, Neuron-glia biology, human brain, Alzheimer's disease
“I met Yifei Cai during the opening keynote by Dana Pe’er; we happened to sit next to each other and immediately connected over how exciting the talk was”. And that’s how our beautiful (and wonderfully productive) collaboration got started!
A poster, a conversation, and a cross-Atlantic collaboration where bioinformatics meets neuroscience to uncover new insights into Alzheimer’s disease 🌍🧠
www.ebi.ac.uk/about/news/t...
#Alzheimers 🖥️🧬
www.ebi.ac.uk/about/news/t...
#Alzheimers 🖥️🧬
From bench to code: collaboration unlocks insights into Alzheimer’s disease
How a chance encounter resulted in a fruitful cross-Atlantic research collaboration
www.ebi.ac.uk
July 31, 2025 at 8:33 PM
“I met Yifei Cai during the opening keynote by Dana Pe’er; we happened to sit next to each other and immediately connected over how exciting the talk was”. And that’s how our beautiful (and wonderfully productive) collaboration got started!
In our most recent paper, we uncover the myelin-axon interactome in human brains and reveal molecular perturbations and structural disruptions at the myelin-axon interface in Alzheimer’s disease @jgrutzendler.bsky.social @epetsalaki.bsky.social @reimand.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience
In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...
www.nature.com
June 16, 2025 at 4:10 PM
In our most recent paper, we uncover the myelin-axon interactome in human brains and reveal molecular perturbations and structural disruptions at the myelin-axon interface in Alzheimer’s disease @jgrutzendler.bsky.social @epetsalaki.bsky.social @reimand.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share that two studies from my postdoc research were published back to back! In the first, we uncovered the molecular basis of axon spheroids—a key hallmark of Alzheimer's disease—and demonstrated their potential reversibility.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging
Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...
www.nature.com
June 16, 2025 at 3:40 PM
Excited to share that two studies from my postdoc research were published back to back! In the first, we uncovered the molecular basis of axon spheroids—a key hallmark of Alzheimer's disease—and demonstrated their potential reversibility.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Yifei Cai
Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease.
🔗 Read here: www.nature.com/articles/s43...
🔗 Read here: www.nature.com/articles/s43...
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging
Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...
www.nature.com
March 10, 2025 at 11:23 PM
Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease.
🔗 Read here: www.nature.com/articles/s43...
🔗 Read here: www.nature.com/articles/s43...
Reposted by Yifei Cai
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
June 14, 2025 at 4:13 PM
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...