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yaoxiaofang.bsky.social
yaoxiaofang
@yaoxiaofang.bsky.social
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imetascience.bsky.social
💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation
onlinelibrary.wiley.com/doi/10.1002/...
Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation
Microbiota-gut-brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood-brain barrier (BBB), an...
onlinelibrary.wiley.com
December 17, 2025 at 11:55 AM
Reposted by yaoxiaofang
imetascience.bsky.social
⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish
Evidence for liver metabolism of gut-derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mann....
onlinelibrary.wiley.com
December 22, 2025 at 10:43 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer
We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The...
onlinelibrary.wiley.com
December 23, 2025 at 12:39 PM
Reposted by yaoxiaofang
imetascience.bsky.social
How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...
December 25, 2025 at 10:55 AM
Reposted by yaoxiaofang
imetascience.bsky.social
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
onlinelibrary.wiley.com/doi/10.1002/...
January 22, 2026 at 12:35 PM
Reposted by yaoxiaofang
imetascience.bsky.social
🗑️ Global landfill systems are major hotspots for antibiotic resistance genes!
⚙️ Metagenomic analyses reveal highly mobile, plasmid-enriched ARGs—dominated by multidrug resistance—and extensive resistome flows within and beyond landfills.
onlinelibrary.wiley.com/doi/10.1002/...
Resistome flow in global landfill systems
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid-driven gene mobility. Waste flows and environmental pathways sustain the transbou...
onlinelibrary.wiley.com
January 15, 2026 at 12:24 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Distinct sinonasal microbiota define clinical subtypes of CRSwNP.
💡 Microbiome-based stratification may support personalized therapy for CRSwNP. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
January 19, 2026 at 1:14 PM
Reposted by yaoxiaofang
imetascience.bsky.social
⛰️ Gut microbiome–host metabolism supports high-altitude adaptation in ruminants.
The role of the gut microbiome in the regulation of high-altitude adaptation.
onlinelibrary.wiley.com/doi/10.1002/...
The role of the gut microbiome in the regulation of high‐altitude adaptation
This study is the first to elucidate mechanisms of high-altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude sin...
onlinelibrary.wiley.com
January 20, 2026 at 11:33 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
January 21, 2026 at 11:09 AM
Reposted by yaoxiaofang
imetascience.bsky.social
💡 An Interpretable Machine Learning Model for Predicting 5-Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data! onlinelibrary.wiley.com/doi/10.1002/...
An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data
This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5-year survival in breast cancer. The optima...
onlinelibrary.wiley.com
December 26, 2025 at 11:02 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer
onlinelibrary.wiley.com/doi/10.1002/...
December 30, 2025 at 2:36 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100
Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution
Single-cell and transcriptomics from 1.79 million cells identify the forestomach epithelium as the dominant site of antioxidant activity and oxidative phosphorylation (OXPHOS) in the bovine gastroint...
onlinelibrary.wiley.com
January 5, 2026 at 1:09 PM
Reposted by yaoxiaofang
imetascience.bsky.social
🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse.
onlinelibrary.wiley.com/doi/10.1002/...
Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction
The pervasiveness of microplastic pollution poses a growing health risk, yet its long-term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanopartic...
onlinelibrary.wiley.com
January 5, 2026 at 1:16 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/10.1002/...
January 8, 2026 at 11:56 AM
Reposted by yaoxiaofang
imetascience.bsky.social
A fast, robust readout framework advances large-fragment DNA data storage. onlinelibrary.wiley.com/doi/10.1002/...
Fast bootstrap and reliable readout using hidden references for DNA data storage
This study provides a bootstrap readout framework for DNA data storage based on multiple-fold hidden references. We employ a multi-stage alignment and error correction strategy, transforming the de n...
onlinelibrary.wiley.com
January 12, 2026 at 12:43 PM
Reposted by yaoxiaofang
imetascience.bsky.social
🎯 Engineered bacteria target cancer-associated fibroblasts to break tumor protection!
⚙️ CAT-BLAST, a FAP-targeting E. coli platform, selectively eliminates Cancer-associated fibroblasts and induces tumor cell apoptosis via ClyA secretion.
onlinelibrary.wiley.com/doi/10.1002/...
CAT‐BLAST: Engineered bacteria for robust targeting and elimination of cancer‐associated fibroblasts
Cancer-associated fibroblasts (CAFs) construct a protective stromal barrier that promotes tumor growth and resistance to therapy. To dismantle this, we developed CAT-BLAST, an engineered bacterial pl...
onlinelibrary.wiley.com
January 6, 2026 at 1:10 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Gut microbes help black soldier fly larvae cope with excess uric acid.
⚙️ A uric acid–degrading Enterococcus faecalis strain restores larval growth and improves bioconversion efficiency by catabolizing dietary UA. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
January 7, 2026 at 11:58 AM
Reposted by yaoxiaofang
imetascience.bsky.social
👶 MOMMY study profile: a large prospective birth cohort uncovering early-life microbiome transmission in China.
💡 A unique resource to advance global understanding of early-life microbiome–health trajectories. onlinelibrary.wiley.com/doi/10.1002/...
MOMMY study profile: An integrative early‐life multi‐omics cohort in China
MOMMY cohort (The MOther-infant Microbiota transmission and its link to long terM health of babY) is a large, prospective birth cohort uniquely designed to investigate maternal-paternal-infant microb...
onlinelibrary.wiley.com
January 9, 2026 at 10:54 AM
Reposted by yaoxiaofang
imetascience.bsky.social
🌊A global estuarine virome reveals active virus-carried antibiotic resistance genes.
onlinelibrary.wiley.com/doi/10.1002/...
Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs ...
onlinelibrary.wiley.com
January 14, 2026 at 1:04 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
Tidyplots empowers life scientists with easy code‐based data visualization
Effective data visualization is vital for analyzing and communicating experimental results. However, most code-based plotting tools require substantial programming experience, posing a significant ba....
onlinelibrary.wiley.com
March 20, 2025 at 8:56 AM