Yannick Alexandre
@yannick-alexandre.bsky.social
Immunologist at the Peter Doherty Institute, University of Melbourne.
NHMRC Emerging Leader fellow
Lymphoid tissue stromal cells and immunity
NHMRC Emerging Leader fellow
Lymphoid tissue stromal cells and immunity
Pinned
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
www.science.org
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
Reposted by Yannick Alexandre
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 5, 2025 at 1:12 AM
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
www.science.org
June 5, 2025 at 12:32 AM
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
Reposted by Yannick Alexandre
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS
The lungs are constantly exposed to the external environment and a myriad of antigenic
challenges within the air. Chronic exposure to allergens and...
doi.org
April 3, 2025 at 3:03 AM
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Congratulations on this fantastic achievement @smguillaume.bsky.social and team!
So proud to have my first first-author paper out there in @pnas.org! Thanks so much to everyone involved, especially @linterman.bsky.social and @wsfoster.bsky.social for your support and guidance. Now onto the next one!!
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
April 4, 2025 at 9:02 AM
Congratulations on this fantastic achievement @smguillaume.bsky.social and team!
Reposted by Yannick Alexandre
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
March 27, 2025 at 4:25 AM
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Yannick Alexandre
March 2, 2025 at 4:07 PM
Reposted by Yannick Alexandre
Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 21, 2025 at 8:24 PM
Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!
Reposted by Yannick Alexandre
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature
The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.
www.nature.com
February 5, 2025 at 7:04 PM
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yannick Alexandre
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…
sciencedirect.com
February 4, 2025 at 8:50 PM
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
Reposted by Yannick Alexandre
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
January 31, 2025 at 11:23 PM
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
Congratulations Daniel, Catarina and team for this beautiful study and huge accomplishment 👏🏼
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 11:35 PM
Congratulations Daniel, Catarina and team for this beautiful study and huge accomplishment 👏🏼