Thanks for the highlight @gzaffagnini.bsky.social !

This beautiful story is from talented PhD student in the lab Amal Shawahny.

Thank you!

Congratulations to authors Amal Shawahny, Yoel Bogoch, and Neta Hart ! 🍾

A special thanks to David Sprinzak for dedicated advice on Notch signaling!🙏

We are privileged to have close friends and amazing partners working with us from Jean-Phillip Junker’s and Susana Lopes’s labs!

We are grateful for for funding from the ISF, DFG Germany-Middle East collaborative grant, BSF, Novo Nordisk Foundation, and support from @embo.org YIP.
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I am super proud of our talented, curious, and courageous Abisch-Frenkel PhD fellow Neta Hart for leading this work!

Learn more about the work in her thread:
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x.com/neta_hart1/s...

By deciphering mechanisms in zebrafish, can we find the missing factors for progenitor maintenance in humans?
This can propose stepping stones towards future female regenerative reproductive medicine.
Modules generate new exciting hypotheses, we can’t wait to investigate!
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Modules propose a new morphogenetic framework for #oogenesis in vertebrates, with important implications to stem cell biology and reproduction.

Ex Ovo Omnia!
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We discovered ovarian modules in zebrafish and humans - morphogenetic units wherein germline stem cells/early progenitors produce differentiating oocytes in a spatially linear developmental manner, controlled by #Notch signaling.
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In species with non-synchronous ovarian development like zebrafish & humans, the production of oocytes from early progenitors is poorly understood. In zebrafish, germline stem cells produce oocytes throughout life, but how they are maintained and produce oocytes is unknown.
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Thank you!

We are grateful for funding and support by
@erc.europa.eu a.eu, and @embo.org YIP, Dutch Organization for Health Research and Development, Novo Nordisk Foundation, DFG, BMBF, National Natural Science Foundation of China, Beijing Municipal Science & Technology Commission, A*STAR, and more.

We have been tremendously fortunate to be working with the great partners, colleagues, and friends who made this work possible!

Importantly, we are humbly grateful for the patients for their contributions🙏

We are proud to lead a huge interdisciplinary, international cross-species collaborative study in #zebrafish, #mouse, and #human ovaries, as well as infertile female and male patients data.

See thread from the other side by our super-talented co-first author Avishag Mytlis:
x.com/AMytlis/stat...

In brief, our findings uncover a strikingly conserved #ciliary mechanism in the regulation of chromosomal dynamics in #meiosis, and implicate dysfunction of the zygotene cilium as an overlooked etiology of human #infertility, also expanding the spectrum of #ciliopathies.
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