Yaniv Elkouby
@yanivelkouby.bsky.social
Assoc. Professor @HebrewU.
Illuminating unpredicted cellular machineries in germ cell production, gonad development and reproduction.
#zebrafish @ERC_Research @EMBO_YIP
Co-founder, Forsea: cultured seafood, oceans wealth
https://www.yanivelkoubylab.com/
Illuminating unpredicted cellular machineries in germ cell production, gonad development and reproduction.
#zebrafish @ERC_Research @EMBO_YIP
Co-founder, Forsea: cultured seafood, oceans wealth
https://www.yanivelkoubylab.com/
Congratulations to authors Amal Shawahny, Yoel Bogoch, and Neta Hart ! 🍾
November 27, 2025 at 11:58 AM
Congratulations to authors Amal Shawahny, Yoel Bogoch, and Neta Hart ! 🍾
Now out from our lab in @currentbiology.bsky.social!
An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization
www.cell.com/current-biol...
An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization
www.cell.com/current-biol...
November 26, 2025 at 7:01 PM
Now out from our lab in @currentbiology.bsky.social!
An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization
www.cell.com/current-biol...
An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization
www.cell.com/current-biol...
Was a pleasure to participate in ScoRe - Scientific Conference On REproduction - celebrating 150/y since the observation of sperm and egg pronuclear fusion in @flatironinstitute.org.
A stellar gathering discussing all things germ cells!
Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!
A stellar gathering discussing all things germ cells!
Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!
November 19, 2025 at 8:34 PM
Was a pleasure to participate in ScoRe - Scientific Conference On REproduction - celebrating 150/y since the observation of sperm and egg pronuclear fusion in @flatironinstitute.org.
A stellar gathering discussing all things germ cells!
Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!
A stellar gathering discussing all things germ cells!
Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!
By deciphering mechanisms in zebrafish, can we find the missing factors for progenitor maintenance in humans?
This can propose stepping stones towards future female regenerative reproductive medicine.
Modules generate new exciting hypotheses, we can’t wait to investigate!
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This can propose stepping stones towards future female regenerative reproductive medicine.
Modules generate new exciting hypotheses, we can’t wait to investigate!
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October 30, 2025 at 4:01 PM
By deciphering mechanisms in zebrafish, can we find the missing factors for progenitor maintenance in humans?
This can propose stepping stones towards future female regenerative reproductive medicine.
Modules generate new exciting hypotheses, we can’t wait to investigate!
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This can propose stepping stones towards future female regenerative reproductive medicine.
Modules generate new exciting hypotheses, we can’t wait to investigate!
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Modules propose a new morphogenetic framework for #oogenesis in vertebrates, with important implications to stem cell biology and reproduction.
Ex Ovo Omnia!
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Ex Ovo Omnia!
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October 30, 2025 at 4:01 PM
Modules propose a new morphogenetic framework for #oogenesis in vertebrates, with important implications to stem cell biology and reproduction.
Ex Ovo Omnia!
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Ex Ovo Omnia!
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We discovered ovarian modules in zebrafish and humans - morphogenetic units wherein germline stem cells/early progenitors produce differentiating oocytes in a spatially linear developmental manner, controlled by #Notch signaling.
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October 30, 2025 at 4:01 PM
We discovered ovarian modules in zebrafish and humans - morphogenetic units wherein germline stem cells/early progenitors produce differentiating oocytes in a spatially linear developmental manner, controlled by #Notch signaling.
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In species with non-synchronous ovarian development like zebrafish & humans, the production of oocytes from early progenitors is poorly understood. In zebrafish, germline stem cells produce oocytes throughout life, but how they are maintained and produce oocytes is unknown.
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October 30, 2025 at 4:01 PM
In species with non-synchronous ovarian development like zebrafish & humans, the production of oocytes from early progenitors is poorly understood. In zebrafish, germline stem cells produce oocytes throughout life, but how they are maintained and produce oocytes is unknown.
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Super proud of Neta Hart for being awarded the travel grant by The Science Bank and for delivering an excellent talk at the Notch Signaling Meeting about her pioneering work on newly identified mode of early #oogenesis in #zebrafish and human, regulated by Notch (more to come!).
October 8, 2025 at 6:52 PM
Super proud of Neta Hart for being awarded the travel grant by The Science Bank and for delivering an excellent talk at the Notch Signaling Meeting about her pioneering work on newly identified mode of early #oogenesis in #zebrafish and human, regulated by Notch (more to come!).
For the new Jewish year, we wish for a better and peaceful year all around, filled with joy, prosperity, and lots of scientific discoveries 🙏🏼
September 23, 2025 at 12:15 PM
For the new Jewish year, we wish for a better and peaceful year all around, filled with joy, prosperity, and lots of scientific discoveries 🙏🏼
I can now share that during the recent Israel-Iran conflict, our main #zebrafish husbandry facility collapsed abruptly, resulting in the loss of ~85% of our fish.
With careful management, we were able to preserve all lines, and are currently operating from backup systems.
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With careful management, we were able to preserve all lines, and are currently operating from backup systems.
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August 15, 2025 at 1:06 PM
I can now share that during the recent Israel-Iran conflict, our main #zebrafish husbandry facility collapsed abruptly, resulting in the loss of ~85% of our fish.
With careful management, we were able to preserve all lines, and are currently operating from backup systems.
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With careful management, we were able to preserve all lines, and are currently operating from backup systems.
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Two Elkouby lab students received the Hebrew University @hebrewuniversity.bsky.social Faculty of Medicine Prizes for Outstanding MSc Thesis today.
Congratulations Amal Shawahny and Adam Ahmad for this well deserved recognition, we are super proud of you!
🎉🐟
Congratulations Amal Shawahny and Adam Ahmad for this well deserved recognition, we are super proud of you!
🎉🐟
July 24, 2025 at 8:07 PM
Two Elkouby lab students received the Hebrew University @hebrewuniversity.bsky.social Faculty of Medicine Prizes for Outstanding MSc Thesis today.
Congratulations Amal Shawahny and Adam Ahmad for this well deserved recognition, we are super proud of you!
🎉🐟
Congratulations Amal Shawahny and Adam Ahmad for this well deserved recognition, we are super proud of you!
🎉🐟
Grateful to the Israel Science Foundation for additional five years of funding!
Thank you to all reviewers and panel members out there for believing in our science.
Excited for what’s coming next 🤞🏻
Thank you to all reviewers and panel members out there for believing in our science.
Excited for what’s coming next 🤞🏻
July 18, 2025 at 4:04 PM
Grateful to the Israel Science Foundation for additional five years of funding!
Thank you to all reviewers and panel members out there for believing in our science.
Excited for what’s coming next 🤞🏻
Thank you to all reviewers and panel members out there for believing in our science.
Excited for what’s coming next 🤞🏻
Was a pleasure to give the @embo.org talk in #EMBO #meiosis meeting today, and share our findings about the Zygotene #cilium: novel mechanisms, conserved functions and links to human #reproduction disfunction.
Thanks to the organizers for the invite and for a fantastic meeting.
Thanks to the organizers for the invite and for a fantastic meeting.
June 23, 2025 at 5:28 PM
Was a pleasure to give the @embo.org talk in #EMBO #meiosis meeting today, and share our findings about the Zygotene #cilium: novel mechanisms, conserved functions and links to human #reproduction disfunction.
Thanks to the organizers for the invite and for a fantastic meeting.
Thanks to the organizers for the invite and for a fantastic meeting.
My students @amytlis.bsky.social, Karine Levy, and myself were invited to speak at the Foundation Singer-Polignac #Fertilty meeting, Paris.
We could not join in person at the current circumstances.
This is how I ended my talk: 🔊
We could not join in person at the current circumstances.
This is how I ended my talk: 🔊
June 19, 2025 at 9:21 AM
My students @amytlis.bsky.social, Karine Levy, and myself were invited to speak at the Foundation Singer-Polignac #Fertilty meeting, Paris.
We could not join in person at the current circumstances.
This is how I ended my talk: 🔊
We could not join in person at the current circumstances.
This is how I ended my talk: 🔊
Iranian missiles or on the way…
I’m in one bomb shelter, my student Neta is in another, yet we are working on our next paper, shelter-to-shelter.
The passion for science and the human spirit will always prevail!
I’m in one bomb shelter, my student Neta is in another, yet we are working on our next paper, shelter-to-shelter.
The passion for science and the human spirit will always prevail!
June 15, 2025 at 1:35 PM
Iranian missiles or on the way…
I’m in one bomb shelter, my student Neta is in another, yet we are working on our next paper, shelter-to-shelter.
The passion for science and the human spirit will always prevail!
I’m in one bomb shelter, my student Neta is in another, yet we are working on our next paper, shelter-to-shelter.
The passion for science and the human spirit will always prevail!
Was a pleasure to serve on the interviewing panel for the @maxperutzlabs.bsky.social PhD scholarship in @viennabiocenter.bsky.social .
All finalists were outstanding with excellent and exciting science. Congratulations to the winners!
All finalists were outstanding with excellent and exciting science. Congratulations to the winners!
June 11, 2025 at 1:37 PM
Was a pleasure to serve on the interviewing panel for the @maxperutzlabs.bsky.social PhD scholarship in @viennabiocenter.bsky.social .
All finalists were outstanding with excellent and exciting science. Congratulations to the winners!
All finalists were outstanding with excellent and exciting science. Congratulations to the winners!
Super-talented PhD students, Neta Hart and Avishag Mytlis, from our lab rocking the annual meeting of the Israeli #Fertility Association with two talks in one session!
Making some splash introducing #zebrafish to the meeting 🐟
@zebrafishrock.bsky.social
Making some splash introducing #zebrafish to the meeting 🐟
@zebrafishrock.bsky.social
May 12, 2025 at 2:32 PM
Super-talented PhD students, Neta Hart and Avishag Mytlis, from our lab rocking the annual meeting of the Israeli #Fertility Association with two talks in one session!
Making some splash introducing #zebrafish to the meeting 🐟
@zebrafishrock.bsky.social
Making some splash introducing #zebrafish to the meeting 🐟
@zebrafishrock.bsky.social
Was a great pleasure to visit @pennmedicine.bsky.social yesterday and give a seminar at my postdoc alma mater @upenn.bsky.social CDB.
Thanks @marymullins.bsky.social and @buenoscience.bsky.social for having me!
Thanks @marymullins.bsky.social and @buenoscience.bsky.social for having me!
April 10, 2025 at 8:26 PM
Was a great pleasure to visit @pennmedicine.bsky.social yesterday and give a seminar at my postdoc alma mater @upenn.bsky.social CDB.
Thanks @marymullins.bsky.social and @buenoscience.bsky.social for having me!
Thanks @marymullins.bsky.social and @buenoscience.bsky.social for having me!
Honored to have given the keynote lecture at the DBSUMI meeting. Such an exciting dev bio community!
Thanks @zakswartz.bsky.social for the invitation and kind hospitality at wonderful @mblscience.bsky.social. The naturalist approach to science and rich history in this place are inspiring.
Thanks @zakswartz.bsky.social for the invitation and kind hospitality at wonderful @mblscience.bsky.social. The naturalist approach to science and rich history in this place are inspiring.
April 4, 2025 at 3:01 PM
Honored to have given the keynote lecture at the DBSUMI meeting. Such an exciting dev bio community!
Thanks @zakswartz.bsky.social for the invitation and kind hospitality at wonderful @mblscience.bsky.social. The naturalist approach to science and rich history in this place are inspiring.
Thanks @zakswartz.bsky.social for the invitation and kind hospitality at wonderful @mblscience.bsky.social. The naturalist approach to science and rich history in this place are inspiring.
I had a great time visiting Princeton Department of Molecular Biology. Such an honor presenting our work to an audience of giants in the field and meet passionate dev bio trainees.
Thanks to the organizers of the Colloquium Series on Developmental Biology for the invitation!
Thanks to the organizers of the Colloquium Series on Developmental Biology for the invitation!
March 29, 2025 at 8:07 PM
I had a great time visiting Princeton Department of Molecular Biology. Such an honor presenting our work to an audience of giants in the field and meet passionate dev bio trainees.
Thanks to the organizers of the Colloquium Series on Developmental Biology for the invitation!
Thanks to the organizers of the Colloquium Series on Developmental Biology for the invitation!
By combining genetics, pharmacological manipulations, and rescue experiments, we constructed a novel mTOR-Stat3-Stathmin pathway that orchestrates centrosome regulation and microtubule organization, thereby establishing oocyte polarization competence.
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February 28, 2025 at 4:20 PM
By combining genetics, pharmacological manipulations, and rescue experiments, we constructed a novel mTOR-Stat3-Stathmin pathway that orchestrates centrosome regulation and microtubule organization, thereby establishing oocyte polarization competence.
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Upstream, we identified mTOR as activator of Stat3.
mTOR is active in oocytes (A), and required ex-vivo for polarity (B) and for Stat3 activation (C).
Stathmin inhibition rescued polarity in mTOR deficient ovaries, confirming that mTOR acts upstream of Stat3-Stathmin (D-E).
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mTOR is active in oocytes (A), and required ex-vivo for polarity (B) and for Stat3 activation (C).
Stathmin inhibition rescued polarity in mTOR deficient ovaries, confirming that mTOR acts upstream of Stat3-Stathmin (D-E).
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February 28, 2025 at 4:20 PM
Upstream, we identified mTOR as activator of Stat3.
mTOR is active in oocytes (A), and required ex-vivo for polarity (B) and for Stat3 activation (C).
Stathmin inhibition rescued polarity in mTOR deficient ovaries, confirming that mTOR acts upstream of Stat3-Stathmin (D-E).
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mTOR is active in oocytes (A), and required ex-vivo for polarity (B) and for Stat3 activation (C).
Stathmin inhibition rescued polarity in mTOR deficient ovaries, confirming that mTOR acts upstream of Stat3-Stathmin (D-E).
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Stathmin inhibition on stat3-/- background also rescued microtubule (B) and centrosome (C) organization, strongly supporting our hypothesis and demonstrating that Stathmin acts downstream of Stat3.
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February 28, 2025 at 4:20 PM
Stathmin inhibition on stat3-/- background also rescued microtubule (B) and centrosome (C) organization, strongly supporting our hypothesis and demonstrating that Stathmin acts downstream of Stat3.
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If this hypothesis is correct, inhibiting Stathmin in stat3-/- ovaries should prevent microtubule destabilization and rescue polarity.
Indeed, we identified Stathmin in oocytes (A-B), and Stathmin inhibition on stat3-/- background ex-vivo rescued polarity (C).
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Indeed, we identified Stathmin in oocytes (A-B), and Stathmin inhibition on stat3-/- background ex-vivo rescued polarity (C).
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February 28, 2025 at 4:20 PM
If this hypothesis is correct, inhibiting Stathmin in stat3-/- ovaries should prevent microtubule destabilization and rescue polarity.
Indeed, we identified Stathmin in oocytes (A-B), and Stathmin inhibition on stat3-/- background ex-vivo rescued polarity (C).
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Indeed, we identified Stathmin in oocytes (A-B), and Stathmin inhibition on stat3-/- background ex-vivo rescued polarity (C).
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Centrosome (maroon) aberrations were concomitant with loss of Buc (cyan) polarity.
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February 28, 2025 at 4:20 PM
Centrosome (maroon) aberrations were concomitant with loss of Buc (cyan) polarity.
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