Yale MB&B
@yalembb.bsky.social
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT
Reposted by Yale MB&B
🧠Pain sensors need to switch on fast—and off just as quickly.
In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.
📰 rdcu.be/eJcMK
In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.
📰 rdcu.be/eJcMK
Calmodulin binding is required for calcium mediated TRPA1 desensitization
Nature Communications - For pain signaling to be useful, sensory receptors must rapidly detect noxious stimuli and efficiently turn off once the threat has passed. Here, the authors uncover a...
rdcu.be
October 2, 2025 at 6:46 PM
🧠Pain sensors need to switch on fast—and off just as quickly.
In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.
📰 rdcu.be/eJcMK
In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.
📰 rdcu.be/eJcMK
Thank you to everyone who attended this year’s retreat at the Heritage Hotel. A special thank you to retreat coordinators Enrique De La Cruz, Rachel Agosto, and Liz Vellali!
September 22, 2025 at 3:09 PM
Thank you to everyone who attended this year’s retreat at the Heritage Hotel. A special thank you to retreat coordinators Enrique De La Cruz, Rachel Agosto, and Liz Vellali!
Malvankar lab publishes pioneer research delving into the quantum mechanics underlying bacterial respiration
mbb.yale.edu/news/malvank...
mbb.yale.edu/news/malvank...
September 15, 2025 at 1:06 PM
Malvankar lab publishes pioneer research delving into the quantum mechanics underlying bacterial respiration
mbb.yale.edu/news/malvank...
mbb.yale.edu/news/malvank...
Ailong Ke Leads Study Revealing Hidden RNA‑Editing Activity in CRISPR‑Cas9
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Conversion of IscB and Cas9 into RNA-guided RNA editors
An engineered RNA-guided editing platform for efficient gene knockdown and sequence
correction at the mRNA level.
www.cell.com
August 20, 2025 at 3:18 PM
Ailong Ke Leads Study Revealing Hidden RNA‑Editing Activity in CRISPR‑Cas9
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Yale MB&B
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
August 18, 2025 at 6:15 PM
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
Congratulations to Enrique M. De La Cruz for his election as President of the Biophysics Society! mbb.yale.edu/news/congrat...
August 18, 2025 at 6:19 PM
Congratulations to Enrique M. De La Cruz for his election as President of the Biophysics Society! mbb.yale.edu/news/congrat...
Reposted by Yale MB&B
🔬 Join us LIVE on Zoom this Wednesday, June 11, at 4 PM ET!
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
June 2, 2025 at 7:50 PM
🔬 Join us LIVE on Zoom this Wednesday, June 11, at 4 PM ET!
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
Reposted by Yale MB&B
🧬 June RNA Club at Yale
📅 Tuesday, June 10th, 2025
📍 Location: Bass Center 305, Yale Science Building (Science Hill)
This month’s speakers:
🔹 Dr. Chengtao Xu (Ke Lab)
🔹 Dr. Jyotsna Kumar (Garg Lab)
📣 Come for the science—stay for the conversations!
📅 Tuesday, June 10th, 2025
📍 Location: Bass Center 305, Yale Science Building (Science Hill)
This month’s speakers:
🔹 Dr. Chengtao Xu (Ke Lab)
🔹 Dr. Jyotsna Kumar (Garg Lab)
📣 Come for the science—stay for the conversations!
June 5, 2025 at 2:46 PM
🧬 June RNA Club at Yale
📅 Tuesday, June 10th, 2025
📍 Location: Bass Center 305, Yale Science Building (Science Hill)
This month’s speakers:
🔹 Dr. Chengtao Xu (Ke Lab)
🔹 Dr. Jyotsna Kumar (Garg Lab)
📣 Come for the science—stay for the conversations!
📅 Tuesday, June 10th, 2025
📍 Location: Bass Center 305, Yale Science Building (Science Hill)
This month’s speakers:
🔹 Dr. Chengtao Xu (Ke Lab)
🔹 Dr. Jyotsna Kumar (Garg Lab)
📣 Come for the science—stay for the conversations!
Reposted by Yale MB&B
We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
June 9, 2025 at 3:06 PM
We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
Join us next week for MB&B's Computational Biophysics & Biochemistry Symposium on 6/17 in Bass 305!
June 9, 2025 at 2:53 PM
Join us next week for MB&B's Computational Biophysics & Biochemistry Symposium on 6/17 in Bass 305!
Reposted by Yale MB&B
we are beyond proud that our @yalembb.bsky.social @schliekerlab.bsky.social undergraduate researcher Sophia graduated as the sole @Yale Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!
May 19, 2025 at 7:41 PM
we are beyond proud that our @yalembb.bsky.social @schliekerlab.bsky.social undergraduate researcher Sophia graduated as the sole @Yale Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!
Join our department as a Lecturer!
Apply here: apply.interfolio.com/163609.
Apply here: apply.interfolio.com/163609.
April 4, 2025 at 8:19 PM
Join our department as a Lecturer!
Apply here: apply.interfolio.com/163609.
Apply here: apply.interfolio.com/163609.
Reposted by Yale MB&B
📣 New work from MB&B graduate student Max Paul, published in PNAS, reveals how a conserved region of the RasGAP C2 domain enhances enzymatic activity via allosteric interaction with Ras. Structural & functional data suggest a key role in Ras regulation! 🧫🔬 mbb.yale.edu/news/mbb-gra...
February 11, 2025 at 5:24 AM
📣 New work from MB&B graduate student Max Paul, published in PNAS, reveals how a conserved region of the RasGAP C2 domain enhances enzymatic activity via allosteric interaction with Ras. Structural & functional data suggest a key role in Ras regulation! 🧫🔬 mbb.yale.edu/news/mbb-gra...
We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components. Join us in MB&B!
Apply now at apply.interfolio.com/162132
Apply now at apply.interfolio.com/162132
February 10, 2025 at 4:39 PM
We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components. Join us in MB&B!
Apply now at apply.interfolio.com/162132
Apply now at apply.interfolio.com/162132