In this article, the broken science–society contract contention of Glavovic et al. (Glavovic et al. 2022 Clim. Dev. 14, 829–833 (doi:10.1080/17565529.2021.2008855)) and their posit of the tragedy of c...

An international team of astronomers has discovered a massive cloud of gas and dust located in a little-known region of our Milky Way galaxy. The Giant Molecular Cloud (GMC) is about 60 parsecs—or 200...

Maturation of human pluripotent stem (hPS) cell-derived cardiomyocytes is critical for their use as a model system. Here we mimic human heart maturation pathways in the setting of hPS cell-derived cardiac organoids (hCOs). Specifically, transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor enhanced cardiomyocyte maturation, inducing expression of mature sarcomeric and oxidative phosphorylation proteins, and increasing metabolic capacity. hCOs generated using the directed maturation protocol (DM-hCOs) recapitulate cardiac drug responses and, when derived from calsequestrin 2 (CASQ2) and ryanodine receptor 2 (RYR2) mutant hPS cells exhibit a pro-arrhythmia phenotype. These DM-hCOs also comprise multiple cell types, which we characterize and benchmark to the human heart. Modeling of cardiomyopathy caused by a desmoplakin (DSP) mutation resulted in fibrosis and cardiac dysfunction and led to identifying the bromodomain and extra-terminal inhibitor INCB054329

Scientists have developed a breakthrough food supplement that could help save honeybees from devastating declines. By engineering yeast to produce six essential sterols found in pollen, researchers pr...