yahfly.bsky.social
@yahfly.bsky.social
Reposted
Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
sites.stat.columbia.edu
October 4, 2025 at 6:07 PM
Reposted
"If the IPCC was to earnestly assure the transformation of IAM clarity from its present state of a black-box to that of a glass-box, then its proclaimed mantra of ‘neutral, policy relevant but not policy prescriptive’ could be received with high confidence."

#sts #philsci

doi.org/10.1098/rsos...
Blurred boundaries at the Intergovernmental Panel on Climate Change: the role of integrated assessment models in the science–society contract | Royal Society Open Science
In this article, the broken science–society contract contention of Glavovic et al. (Glavovic et al. 2022 Clim. Dev. 14, 829–833 (doi:10.1080/17565529.2021.2008855)) and their posit of the tragedy of c...
doi.org
September 19, 2025 at 6:40 AM
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Astronomers with the Green Bank Telescope recently found the Midpoint Cloud, a 200-light-year molecular cloud hidden in the Milky Way’s bar. It contains turbulent gas, star-forming clumps, and a new maser.
🔭🌌✨🧪 #Astronomy
#MilkyWay
#StarFormation
#RadioAstronomy
Astronomers Discover Massive Molecular Cloud Hidden in Milky Way
An international team of astronomers has discovered a massive cloud of gas and dust located in a little-known region of our Milky Way galaxy. The Giant Molecular Cloud (GMC) is about 60 parsecs—or 200...
greenbankobservatory.org
September 5, 2025 at 3:58 AM
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Mature heart organoids emulate human heart pathways via hPS cells, boosting sarcomeric proteins, oxidative phosphorylation, and metabolism. PMID:40562874, Nat Cardiovasc Res 2025 https://doi.org/10.1038/s44161-025-00669-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Maturation of human cardiac organoids enables complex disease modeling and drug discovery | Nature Cardiovascular Research
Maturation of human pluripotent stem (hPS) cell-derived cardiomyocytes is critical for their use as a model system. Here we mimic human heart maturation pathways in the setting of hPS cell-derived cardiac organoids (hCOs). Specifically, transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor enhanced cardiomyocyte maturation, inducing expression of mature sarcomeric and oxidative phosphorylation proteins, and increasing metabolic capacity. hCOs generated using the directed maturation protocol (DM-hCOs) recapitulate cardiac drug responses and, when derived from calsequestrin 2 (CASQ2) and ryanodine receptor 2 (RYR2) mutant hPS cells exhibit a pro-arrhythmia phenotype. These DM-hCOs also comprise multiple cell types, which we characterize and benchmark to the human heart. Modeling of cardiomyopathy caused by a desmoplakin (DSP) mutation resulted in fibrosis and cardiac dysfunction and led to identifying the bromodomain and extra-terminal inhibitor INCB054329
doi.org
September 5, 2025 at 6:10 AM
Reposted
Yesterday we visited Green Mountain Falls, CO to visit the kinetic sculpture Off the Beaten Path by Patrick Shearn. I wasn’t ready for just how dynamic it was even in the slightest breeze. Reminds me of a murmuration of starlings. Incredible artwork. It’ll only be up through October 19th.
September 2, 2025 at 7:47 PM
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Timeline cleanse 😁

I live on 8 acres in a pocket of more sparsely developed, unincorporated county land surrounded by city. There's a family of deer that have used this land and our neighborhood as a safe island. So most days I get a visit from the neighbors just outside my office window.
September 3, 2025 at 8:58 PM
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John Lee Hooker at his Woodside, California home circa 1997.
#bluesmusic
Photo by ©Peter DaSilva
September 3, 2025 at 2:45 PM
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The state of America: Cyndi Lauper changes the lyrics to Girls Just Want to Have Fun to Girls Just Want Fundamental Rights.....
September 2, 2025 at 11:38 PM
#fungifriday Ringless Honey Mushroom?
August 30, 2025 at 2:44 AM
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magazine screenshot, login, magazine (1989) archive.org/details/logi...
August 24, 2025 at 12:45 PM
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AKIRA (1988, Katsuhiro Otomo)
August 24, 2025 at 1:36 AM