Xinming Tu
@xinmingtu.bsky.social
PhD student @uwcse; ML&CompGenomics&GeneRegulation; Bio&CS undergrad
@PKU1898; Intern@Yale, Microsoft Research Asia, Genentech
@PKU1898; Intern@Yale, Microsoft Research Asia, Genentech
Reposted by Xinming Tu
1/ DNA sequence models like Borzoi predict gene expression and variant effects across tissues — but how can someone adapt the model to a custom experiment? @drkbio.bsky.social, Johannes Linder and I propose a solution via parameter-efficient fine-tuning (PEFT).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Parameter-Efficient Fine-Tuning of a Supervised Regulatory Sequence Model
DNA sequence deep learning models accurately predict epigenetic and transcriptional profiles, enabling analysis of gene regulation and genetic variant effects. While large-scale training models like E...
www.biorxiv.org
June 2, 2025 at 8:09 PM
1/ DNA sequence models like Borzoi predict gene expression and variant effects across tissues — but how can someone adapt the model to a custom experiment? @drkbio.bsky.social, Johannes Linder and I propose a solution via parameter-efficient fine-tuning (PEFT).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Xinming Tu
Want to learn more about PromoterAI?
📄 Read the paper: science.org/doi/10.1126/...
💻 Explore the code & precomputed scores: github.com/Illumina/Pro.... (14/)
📄 Read the paper: science.org/doi/10.1126/...
💻 Explore the code & precomputed scores: github.com/Illumina/Pro.... (14/)
Predicting expression-altering promoter mutations with deep learning
Only a minority of patients with rare genetic diseases are currently diagnosed by exome sequencing, suggesting that additional unrecognized pathogenic variants may reside in non-coding sequence. Here,...
science.org
May 29, 2025 at 11:57 PM
Want to learn more about PromoterAI?
📄 Read the paper: science.org/doi/10.1126/...
💻 Explore the code & precomputed scores: github.com/Illumina/Pro.... (14/)
📄 Read the paper: science.org/doi/10.1126/...
💻 Explore the code & precomputed scores: github.com/Illumina/Pro.... (14/)