Han Yuan
@hy395.bsky.social
ML scientist @Kelley lab @Calico. Previously @Leslie lab @MSKCC @Weill Cornell.
1/ DNA sequence models like Borzoi predict gene expression and variant effects across tissues — but how can someone adapt the model to a custom experiment? @drkbio.bsky.social, Johannes Linder and I propose a solution via parameter-efficient fine-tuning (PEFT).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Parameter-Efficient Fine-Tuning of a Supervised Regulatory Sequence Model
DNA sequence deep learning models accurately predict epigenetic and transcriptional profiles, enabling analysis of gene regulation and genetic variant effects. While large-scale training models like E...
www.biorxiv.org
June 2, 2025 at 8:09 PM
1/ DNA sequence models like Borzoi predict gene expression and variant effects across tissues — but how can someone adapt the model to a custom experiment? @drkbio.bsky.social, Johannes Linder and I propose a solution via parameter-efficient fine-tuning (PEFT).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Han Yuan
Working with a great team to organize
@keystonesymposia.bsky.social AI in MolecularBiology, this September! We aimed for a wide range of biological topics, and emphasized speakers who blend sophisticated machine learning with compelling biological questions and analysis.
@keystonesymposia.bsky.social AI in MolecularBiology, this September! We aimed for a wide range of biological topics, and emphasized speakers who blend sophisticated machine learning with compelling biological questions and analysis.
April 20, 2025 at 6:16 PM
Working with a great team to organize
@keystonesymposia.bsky.social AI in MolecularBiology, this September! We aimed for a wide range of biological topics, and emphasized speakers who blend sophisticated machine learning with compelling biological questions and analysis.
@keystonesymposia.bsky.social AI in MolecularBiology, this September! We aimed for a wide range of biological topics, and emphasized speakers who blend sophisticated machine learning with compelling biological questions and analysis.
Reposted by Han Yuan
⚡️ Our latest preprint is on bioRxiv!
Shift augmentation improves DNA convolutional neural network indel effect predictions
www.biorxiv.org/content/10.1...
Shift augmentation improves DNA convolutional neural network indel effect predictions
www.biorxiv.org/content/10.1...
Shift augmentation improves DNA convolutional neural network indel effect predictions
Determining genetic variant effects on molecular phenotypes like gene expression is a task of paramount importance to medical genetics. DNA convolutional neural networks (CNNs) attain state-of-the-art...
www.biorxiv.org
April 16, 2025 at 9:13 PM
⚡️ Our latest preprint is on bioRxiv!
Shift augmentation improves DNA convolutional neural network indel effect predictions
www.biorxiv.org/content/10.1...
Shift augmentation improves DNA convolutional neural network indel effect predictions
www.biorxiv.org/content/10.1...