Xiaoyu Zhang
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xiaoyuzhang.bsky.social
Xiaoyu Zhang
@xiaoyuzhang.bsky.social
380 followers 280 following 0 posts
Assistant Professor of Chemistry at Northwestern University
https://zhanglabnu.com/
Posts Replies Media Videos
Reposted by Xiaoyu Zhang
dannomura.bsky.social
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.

www.biorxiv.org/content/10.1...
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...
www.biorxiv.org
April 26, 2025 at 1:14 PM
Reposted by Xiaoyu Zhang
brianliau.bsky.social
Interested in small molecule mechanism? If you’re at #ACSSpring2025, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from @michael-erb.bsky.social, Yuh Min Chook & @xiaoyuzhang.bsky.social. I’ll discuss our program on chemical genomics. Come check it out!
March 25, 2025 at 9:47 AM
Reposted by Xiaoyu Zhang
brianliau.bsky.social
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Reposted by Xiaoyu Zhang
nuchemistry.bsky.social
🚨 Don't miss this recent research from the Zhang Lab 🚨
'Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation' #Cancer #Chemistry #ProteinDegredation

Out now in @J_A_C_S ➡️
pubs.acs.org/doi/full/10....

@xiaoyuzhang.bsky.social
Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
pubs.acs.org
February 6, 2025 at 11:37 PM
Reposted by Xiaoyu Zhang
adammgilbert65.bsky.social
Thoughts on why DCAF11, DCAF16 and FBXO22 could be the next workhorse E3 ligases in TPD
doi.org/10.1038/s415...
Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
doi.org
January 27, 2025 at 8:49 PM
Reposted by Xiaoyu Zhang
behnamnabet.bsky.social
🧪 Ready, set, degrade!

So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.

Link: www.jci.org/articles/vie...
December 27, 2024 at 5:04 PM
Reposted by Xiaoyu Zhang
pottslab.bsky.social
Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪 #chembio #TPD #CancerResearch

www.biorxiv.org/content/10.1...
Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
www.biorxiv.org
December 5, 2024 at 4:56 AM
Reposted by Xiaoyu Zhang
achemsynbio.bsky.social
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
December 1, 2024 at 10:37 PM