Behnam Nabet
@behnamnabet.bsky.social
Assistant Professor at Fred Hutchinson Cancer Center
| dTAG designer | Induced Proximity & Targeted Protein Degradation | Proud Husband & Baba | He/Him/His | https://research.fredhutch.org/nabet/en.html
| dTAG designer | Induced Proximity & Targeted Protein Degradation | Proud Husband & Baba | He/Him/His | https://research.fredhutch.org/nabet/en.html
Pinned
Behnam Nabet
@behnamnabet.bsky.social
· Dec 27
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
Reposted by Behnam Nabet
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
bit.ly/Dabas_Pol2
Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
bit.ly
November 7, 2025 at 3:45 PM
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
bit.ly/Dabas_Pol2
Reposted by Behnam Nabet
So many phenomenal pumpkins at this year’s carving contest!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
October 25, 2025 at 12:31 AM
So many phenomenal pumpkins at this year’s carving contest!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
Reposted by Behnam Nabet
When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.
October 27, 2025 at 4:53 PM
When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.
Reposted by Behnam Nabet
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
October 13, 2025 at 8:47 PM
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Reposted by Behnam Nabet
The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...
Harold M. Weintraub Graduate Student Award
Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in the...
www.fredhutch.org
October 1, 2025 at 4:53 PM
The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...
Reposted by Behnam Nabet
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12
Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…
www.sciencedirect.com
September 11, 2025 at 2:03 PM
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Behnam Nabet
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Reposted by Behnam Nabet
Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturation - Nature Communications
HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neu...
www.nature.com
August 23, 2025 at 1:40 PM
Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.
July 25, 2025 at 5:12 PM
The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.
Reposted by Behnam Nabet
We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋
👩🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt
👩🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt
July 22, 2025 at 2:23 PM
We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋
👩🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt
👩🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt
Reposted by Behnam Nabet
🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
July 16, 2025 at 9:05 PM
🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
Reposted by Behnam Nabet
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
careers.dana-farber.org
June 30, 2025 at 7:30 PM
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Reposted by Behnam Nabet
Postdoc positions available! Please re-post!
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Avgousti Lab
Investigating viral manipulation of host chromatin dynamics
avgoustilab.org
June 26, 2025 at 8:24 PM
Postdoc positions available! Please re-post!
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
🚨 New preprint!
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Development of PROTACs for targeted degradation of oncogenic TRK fusions
Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...
www.biorxiv.org
June 25, 2025 at 8:10 PM
🚨 New preprint!
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Reposted by Behnam Nabet
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
May 17, 2025 at 2:45 PM
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Behnam Nabet
Two great talks lined up for the final Friday Afternoon Seminars of the season!
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
May 16, 2025 at 9:21 PM
Two great talks lined up for the final Friday Afternoon Seminars of the season!
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
Reposted by Behnam Nabet
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis of SIFI activity in the integrated stress response - Nature
Nature - Molecular basis of SIFI activity in the integrated stress response
www.nature.com
May 7, 2025 at 10:27 AM
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Behnam Nabet
Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions
Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...
www.biorxiv.org
May 2, 2025 at 12:16 AM
Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
Reposted by Behnam Nabet
Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025 at 9:22 PM
Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome
Reposted by Behnam Nabet
Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
April 29, 2025 at 10:37 PM
Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!
Reposted by Behnam Nabet
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
April 29, 2025 at 10:10 PM
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
Reposted by Behnam Nabet
REVIEW 🚨
Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.
📖 👇
Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.
📖 👇
Targeted protein degradation for cancer therapy - Nature Reviews Cancer
Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.
bit.ly
April 28, 2025 at 3:32 PM
REVIEW 🚨
Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.
📖 👇
Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.
📖 👇
Reposted by Behnam Nabet
Cell biologist and former @FredHutch.bsky.social division leader Dr. Jonathan Cooper retires. Learn about his many years of scientific discovery and time directing the Basic Sciences Division:
Cell biologist and former Fred Hutch division leader Dr. Jonathan Cooper retires
After 40 years of asking good questions of his own science and the science of his colleagues at Fred Hutch, cell biologist Dr. Jonathan Cooper has retired from the Basic Sciences Division.
www.fredhutch.org
March 28, 2025 at 6:13 PM
Cell biologist and former @FredHutch.bsky.social division leader Dr. Jonathan Cooper retires. Learn about his many years of scientific discovery and time directing the Basic Sciences Division:
Standing up for science in Seattle!
March 7, 2025 at 10:07 PM
Standing up for science in Seattle!
Reposted by Behnam Nabet
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
March 6, 2025 at 8:28 PM
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...