Xi-Han Zhang
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xi-hanzhang.bsky.social
Xi-Han Zhang
@xi-hanzhang.bsky.social
PhD student @YalePsychology | @HarvardChanSPH‘19 | @OUC1924 ‘17 computational biology, neuroscience, affective dynamics, mechanisms of change
Congratulations!!!
April 17, 2025 at 5:33 PM
I'm a huge fan of surfplot now!
December 4, 2024 at 6:22 PM
6/6 Wondering what this means for the field? Review article by
@bogglerapture.bsky.social and @konradwagstyl.bsky.social discusses how my paper adds to converging evidence for the organization of the cortex along the sensory-association axis.
www.nature.com/articles/s41...
Converging cortical axes - Nature Neuroscience
The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular specializations to macroscale functional networks. Zhang et al. report that macrosc...
www.nature.com
December 3, 2024 at 10:14 PM
5/6 Functional network assignment can be predicted by cell-type abundances in post-mortem tissue. Motor, visual, and limbic networks, ventral attention/salient networks can be well-predicted. Default, frontoparietal/control, and dorsal attention networks are easier to be predicted as each other.
December 3, 2024 at 10:13 PM
4/6: Large-scale networks possess distinct cellular profiles, hinting at computing motifs for specialized functions. For example, dorsal attention network is enriched by layer 2/3 and layer 5 ITs, whereas ventral attention/salient network is enriched by layer 6 neurons.
December 3, 2024 at 10:11 PM
3/6: Multivariate cellular profiles track the functional gradient architecture of cortex. Permutational canonical correlation analysis, reveals linear combinations of cell type distributions that maximally correlate to each functional gradient.
December 3, 2024 at 10:11 PM
2/6: Univariate cell type distributions align with gradient topographies: SNCG and SST interneurons and excitatory L5 IT are preferably localized at transmodal, and the L4 IT at the unimodal end. Cell types are imputed from gene expression in bulk tissue samples and single-nucleus data.
December 3, 2024 at 10:10 PM
1/6: Here, we examine associations between the spatial abundance of cell-types with functional gradients and networks across the cortical sheet.
December 3, 2024 at 10:08 PM
w/ @avramholmes.bsky.social @sidchop.bsky.social @elvisha.bsky.social KevinAnderson, Hao-Ming Dong, Prashant Emani, Mark Gerstein, Daniel Margulies.
December 3, 2024 at 10:08 PM
Thank you!!
December 3, 2024 at 9:59 PM
Thank you for writing such great views for our work!
December 3, 2024 at 9:59 PM