Matt Wortham
@worthamlab.bsky.social
Assistant Professor at the Barbara Davis Center for Diabetes at University of Colorado Anschutz. The Wortham lab studies how nutrients govern adaptive and maladaptive responses by pancreatic beta cells in health and metabolic disease. www.worthamlab.org
Thanks for the kind words Scott!
July 31, 2025 at 11:56 PM
Thanks for the kind words Scott!
Based on these preclinical studies, we consider SIRT2 a promising target for stimulating beta cell regeneration in diabetes. Thank you NIH & Breakthrough T1D for funding, @iidp.bsky.social for islets, and collaborators Orian Shirihai, Kristen Wells, @goniaguy4.bsky.social, & @auwerx-lab.bsky.social!
July 31, 2025 at 9:32 PM
Based on these preclinical studies, we consider SIRT2 a promising target for stimulating beta cell regeneration in diabetes. Thank you NIH & Breakthrough T1D for funding, @iidp.bsky.social for islets, and collaborators Orian Shirihai, Kristen Wells, @goniaguy4.bsky.social, & @auwerx-lab.bsky.social!
Mechanistically, SIRT2 deacetylates glycolytic and TCA enzymes, dampening islet oxygen consumption during hyperglycemia. In addition to its direct effect on metabolism, SIRT2 impacts how beta cells transcriptionally interpret hyperglycemia as a stress.
July 31, 2025 at 9:32 PM
Mechanistically, SIRT2 deacetylates glycolytic and TCA enzymes, dampening islet oxygen consumption during hyperglycemia. In addition to its direct effect on metabolism, SIRT2 impacts how beta cells transcriptionally interpret hyperglycemia as a stress.
We show that inactivation of SIRT2 increases beta cell proliferation in mice when glucose is elevated above the physiological set point, indicating SIRT2 dampens adaptive beta cell proliferation. SIRT2 also restrains human beta cell proliferation but over a broader range of glucose concentrations.
July 31, 2025 at 9:32 PM
We show that inactivation of SIRT2 increases beta cell proliferation in mice when glucose is elevated above the physiological set point, indicating SIRT2 dampens adaptive beta cell proliferation. SIRT2 also restrains human beta cell proliferation but over a broader range of glucose concentrations.
First off, huge shoutout to co-first authors Bastian Ramms, Chun Zeng, and Jackie Benthuysen from Maike Sander’s lab, and to those who helped with revision experiments including my new colleagues at @cuanschutz.bsky.social @cudevbio.bsky.social
July 31, 2025 at 9:32 PM
First off, huge shoutout to co-first authors Bastian Ramms, Chun Zeng, and Jackie Benthuysen from Maike Sander’s lab, and to those who helped with revision experiments including my new colleagues at @cuanschutz.bsky.social @cudevbio.bsky.social