Matt Wortham
@worthamlab.bsky.social
Assistant Professor at the Barbara Davis Center for Diabetes at University of Colorado Anschutz. The Wortham lab studies how nutrients govern adaptive and maladaptive responses by pancreatic beta cells in health and metabolic disease. www.worthamlab.org
Mechanistically, SIRT2 deacetylates glycolytic and TCA enzymes, dampening islet oxygen consumption during hyperglycemia. In addition to its direct effect on metabolism, SIRT2 impacts how beta cells transcriptionally interpret hyperglycemia as a stress.
July 31, 2025 at 9:32 PM
Mechanistically, SIRT2 deacetylates glycolytic and TCA enzymes, dampening islet oxygen consumption during hyperglycemia. In addition to its direct effect on metabolism, SIRT2 impacts how beta cells transcriptionally interpret hyperglycemia as a stress.
We show that inactivation of SIRT2 increases beta cell proliferation in mice when glucose is elevated above the physiological set point, indicating SIRT2 dampens adaptive beta cell proliferation. SIRT2 also restrains human beta cell proliferation but over a broader range of glucose concentrations.
July 31, 2025 at 9:32 PM
We show that inactivation of SIRT2 increases beta cell proliferation in mice when glucose is elevated above the physiological set point, indicating SIRT2 dampens adaptive beta cell proliferation. SIRT2 also restrains human beta cell proliferation but over a broader range of glucose concentrations.
With credit to @huisinglab.bsky.social for inspiring the tradition, today we bid farewell to our very first lab member Sean Lee who is joining the Cell Biology, Stem Cells, and Development PhD program here at @cuanschutz.bsky.social. Best of luck Sean, we expect great things from you!
June 30, 2025 at 5:00 PM
With credit to @huisinglab.bsky.social for inspiring the tradition, today we bid farewell to our very first lab member Sean Lee who is joining the Cell Biology, Stem Cells, and Development PhD program here at @cuanschutz.bsky.social. Best of luck Sean, we expect great things from you!