William Garland
@willgarland.bsky.social
RNA decay, RNA sorting, transcriptional regulation
Aarhus University, Denmark 🇩🇰
Aarhus University, Denmark 🇩🇰
Reposted by William Garland
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
October 12, 2025 at 8:19 PM
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...
www.biorxiv.org
September 17, 2025 at 10:31 AM
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus!
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/
September 10, 2025 at 6:15 PM
Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus!
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/
Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰
Please share around 🤝
Please share around 🤝
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
July 22, 2025 at 6:07 AM
Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰
Please share around 🤝
Please share around 🤝
Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com
Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex
Article: rdcu.be/euC4U
News & Views: rdcu.be/euC5l
Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex
Article: rdcu.be/euC4U
News & Views: rdcu.be/euC5l
July 3, 2025 at 10:25 AM
Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com
Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex
Article: rdcu.be/euC4U
News & Views: rdcu.be/euC5l
Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex
Article: rdcu.be/euC4U
News & Views: rdcu.be/euC5l
Reposted by William Garland
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
June 27, 2025 at 6:03 AM
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
June 19, 2025 at 6:21 PM
We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
www.biorxiv.org
June 2, 2025 at 12:03 PM
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I've been wanting to try something like this. Awesome to see that it works 👍
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
www.biorxiv.org
April 28, 2025 at 1:27 PM
I've been wanting to try something like this. Awesome to see that it works 👍
Reposted by William Garland
Very proud to share this work just out in NAR: spearheaded by @jamieauxillos.bsky.social and Arnauld Stigliani: TLDR-seq, a method for 5’ to 3’ end long-read sequencing of capped RNAs regardless of 3’ end polyadenylation, based on the @nanoporetech.com platform. (1/4) tinyurl.com/3c2ksdmr
April 7, 2025 at 8:15 AM
Very proud to share this work just out in NAR: spearheaded by @jamieauxillos.bsky.social and Arnauld Stigliani: TLDR-seq, a method for 5’ to 3’ end long-read sequencing of capped RNAs regardless of 3’ end polyadenylation, based on the @nanoporetech.com platform. (1/4) tinyurl.com/3c2ksdmr
Reposted by William Garland
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
February 20, 2025 at 9:53 AM
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
Reposted by William Garland
“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans.
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
We’re launching a new AI system for scientists.
Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. Researchers…
blog.google
February 20, 2025 at 1:05 AM
“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans.
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
Reposted by William Garland
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
January 31, 2025 at 1:49 PM
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
February 7, 2025 at 12:41 PM
New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
Reposted by William Garland
We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org
This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
www2.rnasociety.org
This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
February 4, 2025 at 10:48 PM
We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org
This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
www2.rnasociety.org
This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
Reposted by William Garland
Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
January 31, 2025 at 6:25 PM
Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
Resident colour blind member of the lab here 🙋♂️
Please make your figures friendly to us.
Please make your figures friendly to us.
Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
Color blind friendly palettes for data visualizations with categories
A discussion of color blind friendly palettes for labeling unique catergories in data visualization.
thenode.biologists.com
January 21, 2025 at 11:30 AM
Resident colour blind member of the lab here 🙋♂️
Please make your figures friendly to us.
Please make your figures friendly to us.
Reposted by William Garland
Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci https://www.biorxiv.org/content/10.1101/2025.01.08.631787v1
January 10, 2025 at 6:33 PM
Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci https://www.biorxiv.org/content/10.1101/2025.01.08.631787v1
Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells.
I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
January 7, 2025 at 4:34 PM
Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells.
I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
Reposted by William Garland
40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.
December 29, 2024 at 9:50 AM
40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.
Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️
Back in Derbyshire and busy making sausage rolls.
It's been a productive year, but i'm in dire need of a break.
Back in Derbyshire and busy making sausage rolls.
It's been a productive year, but i'm in dire need of a break.
December 21, 2024 at 2:32 PM
Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️
Back in Derbyshire and busy making sausage rolls.
It's been a productive year, but i'm in dire need of a break.
Back in Derbyshire and busy making sausage rolls.
It's been a productive year, but i'm in dire need of a break.
📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs.
December 13, 2024 at 8:25 AM
📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs.
Reposted by William Garland
Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...
Colour me better: fixing figures for colour blindness
Images can be made more accessible by choosing hues, shapes and textures carefully.
www.nature.com
December 10, 2024 at 3:13 PM
Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...
New preprint!
Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export.
www.biorxiv.org/content/10.1...
Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export.
www.biorxiv.org/content/10.1...
Structural basis for the synergistic assembly of the snRNA export complex
The nuclear cap-binding complex (CBC) and its partner ARS2 play crucial roles in regulating Pol II transcript fate through mutually exclusive interactions with RNA effectors. One such effector, PHAX, ...
www.biorxiv.org
November 29, 2024 at 9:38 AM
New preprint!
Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export.
www.biorxiv.org/content/10.1...
Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export.
www.biorxiv.org/content/10.1...