Krzysztof Wierbilowicz
@wierbilowicz.bsky.social
PhD Student @ Karolinska Institutet | Drug combination therepies for neuroblastoma and cellular barcoding
Pinned
Our new work in @embojournal.org ! 🎉
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
Reposted by Krzysztof Wierbilowicz
Comment in issue 17: Making sense of oxygen sensing
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...
September 2, 2025 at 9:37 AM
Comment in issue 17: Making sense of oxygen sensing
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...
Our new work in @embojournal.org ! 🎉
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
July 23, 2025 at 8:52 AM
Our new work in @embojournal.org ! 🎉
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.
Full: www.embopress.org/doi/full/10....
#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal
Reposted by Krzysztof Wierbilowicz
Bryce Paschal and colleagues show that #PARP7 marks the agonist conformation of androgen receptor for #biquitin conjugation by DTX2 E3 with ADP-ribose reader function, resulting in negative feedback of AR-dependent gene expression
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
July 18, 2025 at 10:50 AM
Bryce Paschal and colleagues show that #PARP7 marks the agonist conformation of androgen receptor for #biquitin conjugation by DTX2 E3 with ADP-ribose reader function, resulting in negative feedback of AR-dependent gene expression
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....