Wei Chen
@weiby.bsky.social
Neuroscience PhD candidate @ Johns Hopkins | Bergles Lab | astrocytes
Reposted by Wei Chen
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Norepinephrine signals through astrocytes to modulate synapses
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...
www.science.org
May 16, 2025 at 4:34 AM
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Wei Chen
✨Once thought to play a supporting function in the brain, new research led by @alexbchen.bsky.social & @mishaahrens.bsky.social shows non-neuronal astroglial cells perform a leading role in regulating the activity of neurons and their connections. 🧠
🔗 www.janelia.org/news/on-the-...
🔗 www.janelia.org/news/on-the-...
May 16, 2025 at 2:19 PM
✨Once thought to play a supporting function in the brain, new research led by @alexbchen.bsky.social & @mishaahrens.bsky.social shows non-neuronal astroglial cells perform a leading role in regulating the activity of neurons and their connections. 🧠
🔗 www.janelia.org/news/on-the-...
🔗 www.janelia.org/news/on-the-...
congrats Alex!!🎉🥳
Excited to share that the astrocyte-centered half of my thesis work is now out @science.org ! With @mishaahrens.bsky.social and @marcduque.bsky.social
science.org/doi/10.1126/... 1/8
science.org/doi/10.1126/... 1/8
Norepinephrine changes behavioral state through astroglial purinergic signaling
Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...
science.org
May 16, 2025 at 2:18 PM
congrats Alex!!🎉🥳
Reposted by Wei Chen
Excited that my co-first author manuscript is now published! Special shoutout to Xuelong Mi in Guoqiang Yu's group, who did all of the development of this fantastic tool, which I’ve applied to segment neuromodulatory and astroglial calcium signals. www.cell.com/cell/fulltex...
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals
AQuA2 is a powerful data analysis platform that decomposes time-lapse imaging datasets
into elementary signaling events, allowing for accurate quantification of spatiotemporal
molecular activity patte...
www.cell.com
April 9, 2025 at 2:08 PM
Excited that my co-first author manuscript is now published! Special shoutout to Xuelong Mi in Guoqiang Yu's group, who did all of the development of this fantastic tool, which I’ve applied to segment neuromodulatory and astroglial calcium signals. www.cell.com/cell/fulltex...
Reposted by Wei Chen
#GRCGlia25 #DwightBirdles is hanging out with his family!
March 12, 2025 at 6:35 AM
#GRCGlia25 #DwightBirdles is hanging out with his family!
Reposted by Wei Chen
Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...
Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…
www.sciencedirect.com
December 18, 2024 at 7:22 PM
Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...