Wei Bian
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weibian.bsky.social
Wei Bian
@weibian.bsky.social
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Reposted by Wei Bian
matthiassoller.bsky.social
Elegant way to test for CRISPR-Cas9 off targets thanks to @weibian.bsky.social @davidmcquarrie.bsky.social @roliarnold.bsky.social @ihaussmann.bsky.social
but there seems very little. At least to say CRISPR-Cas9 is safe for flies
rdcu.be/eUyma
Genetic evaluation of CRISPR-Cas9 off-target effects from deleterious mutations on Drosophila male single X chromosome
rdcu.be
December 13, 2025 at 6:42 PM
Reposted by Wei Bian
matthiassoller.bsky.social
Here is the link
platinum-crispr.bham.ac.uk/predict.pl
December 5, 2024 at 7:44 AM
Reposted by Wei Bian
matthiassoller.bsky.social
Excited to share our new paper describing how ELAV/Hu RNA binding proteins achieve binding specificity now in NAR thanks to fantastic @davidmcquarrie.bsky.social
academic.oup.com/nar/article/...
November 13, 2024 at 8:27 AM
Reposted by Wei Bian
davidmcquarrie.bsky.social
N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs

www.biorxiv.org/content/10.1...
N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...
www.biorxiv.org
November 21, 2024 at 12:02 PM